2011年4月
Flexible Strategy for Syntheses of Spirooxindoles using Palladium-Catalyzed Carbosilylation and Sakurai-Type Cyclization
ORGANIC LETTERS
- ,
- ,
- ,
- ,
- 巻
- 13
- 号
- 7
- 開始ページ
- 1828
- 終了ページ
- 1831
- 記述言語
- 英語
- 掲載種別
- 研究論文（学術雑誌）
- DOI
- 10.1021/ol2003447
- 出版者・発行元
- AMER CHEMICAL SOC
The intramolecular carbosilylation of N-[2-(1,3-butenyl)aryl]carbamoyl chloride has been investigated. The reaction with hexamethyldisilane proceeds smoothly in the presence of a catalytic amount of [Pd(eta(3)-allyl)Cl](2) to give oxindoles with an allylsilane functional group in good yield. The subsequent subjection of the products to a Sakurai-type reaction provides more advanced tricyclic spirooxindoles by controlling the stereochemistry of three contiguous stereogenic centers.
- リンク情報
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- DOI
- https://doi.org/10.1021/ol2003447
- J-GLOBAL
- https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201102254143473785
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/21384892
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000288691600065&DestApp=WOS_CPL
- URL
- http://orcid.org/0000-0002-9361-0857
- ID情報
-
- DOI : 10.1021/ol2003447
- ISSN : 1523-7060
- J-Global ID : 201102254143473785
- ORCIDのPut Code : 21836951
- PubMed ID : 21384892
- Web of Science ID : WOS:000288691600065
- ORCIDで取得されたその他外部ID : a:1:{i:0;a:1:{s:8:"other-id";s:19:"WOS:000288691600065";}}