2022年8月16日
12-O-Tetradecanoylphorbol 13-acetate promotes proliferation and epithelial–mesenchymal transition in HHUA cells cultured on collagen type I gel: A feasible model to find new therapies for endometrial diseases
Bioscience, Biotechnology, and Biochemistry
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- 巻
- 86
- 号
- 10
- 開始ページ
- 1417
- 終了ページ
- 1422
- 記述言語
- 掲載種別
- 研究論文（学術雑誌）
- DOI
- 10.1093/bbb/zbac136
- 出版者・発行元
- Oxford University Press (OUP)
Abstract
HHUA endometrial adenocarcinoma cells aggregated into spheroids when cultured on collagen type I gels. 12-O-Tetradecanoylphorbol 13-acetate, a PKC activator, disassembled the spheroids through epithelial–mesenchymal transition and increased their proliferation rate, while inducing cell death under monolayer culture conditions. These unusual behaviors of endometrial epithelial cells with collagen fibers could be a target for the treatment of some endometrial diseases.
HHUA endometrial adenocarcinoma cells aggregated into spheroids when cultured on collagen type I gels. 12-O-Tetradecanoylphorbol 13-acetate, a PKC activator, disassembled the spheroids through epithelial–mesenchymal transition and increased their proliferation rate, while inducing cell death under monolayer culture conditions. These unusual behaviors of endometrial epithelial cells with collagen fibers could be a target for the treatment of some endometrial diseases.
- リンク情報
- ID情報
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- DOI : 10.1093/bbb/zbac136
- eISSN : 1347-6947