Yoshiki Kuse

Profile Information

Affiliation: Assistant professor, Faculty of Pharmaceutical Science, Gifu Pharmaceutical University
: The Institute of Medical Science, The University of Tokyo

Degree: 博士 (薬科学)(岐阜薬科大学)

Contact information: kuse-yogifu-pu.ac.jp
Researcher number: 70837806
J-GLOBAL ID: 201801009614540074
researchmap Member ID: B000305965

Research Interests

Research Areas

Major Research History

Oct, 2022 - Present

Assistant professor, Faculty of Pharmaceutical Science, Gifu Pharmaceutical University
Oct, 2019 - Sep, 2022

The Institute of Medical Science, The University of Tokyo
Apr, 2018 - Sep, 2019

Yokohama City University
Apr, 2015 - Mar, 2018

日本学術振興会特別研究員 (DC1)

Education

Apr, 2013 - Mar, 2018

Gifu Pharmaceutical University
Apr, 2009 - Mar, 2013

Faculty of Pharmaceutial Science, Faculty of Pharmaceutical Science, Gifu Pharmaceutical University

Awards

Mar, 2024

第23回日本再生医療学会総会優秀演題賞

Papers

Progranulin-deficient macrophages cause cardiotoxicity under hypoxic conditions.

Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa

Biochemical and biophysical research communications, 691 149341-149341, Nov 28, 2023 Peer-reviewed
Progranulin deficiency exacerbates cardiac remodeling after myocardial infarction

Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa, Hideaki Hara

FASEB BioAdvances, 5(10) 395-411, Sep 20, 2023 Peer-reviewed
VGF nerve growth factor inducible has the potential to protect pancreatic β-cells

Hikari Hirakida, Taiga Okumura, Ryosuke Fujita, Yoshiki Kuse, Takahiro Mizoguchi, Satoshi Inagaki, Shinsuke Nakamura, Masamitsu Shimazawa, Hideaki Hara

Journal of Endocrinology, 257(3), Mar 29, 2023 Peer-reviewed
Distribution of Carotenoids and Protective Effects of Zeaxanthin on Retina of Ayu Sweetfish (Plecoglossus altivelis).

Shinsuke Nakamura, Takashi Maoka, Yoshiki Kuse, Aomi Muramatsu, Yuta Yoshino, Masamitsu Shimazawa, Hideaki Hara

Journal of oleo science, 69(9) 1095-1105, Sep 2, 2020 Peer-reviewed
Effects of progranulin on the pathological conditions in experimental myocardial infarction model.

Takahiro Sasaki, Masamitsu Shimazawa, Hiromitsu Kanamori, Yoshihisa Yamada, Anri Nishinaka, Yoshiki Kuse, Genjiro Suzuki, Tomomi Masuda, Shinsuke Nakamura, Masato Hosokawa …

Scientific reports, 10(1) 11842-11842, Jul 16, 2020 Peer-reviewed
Present and Future Perspectives of Using Human-Induced Pluripotent Stem Cells and Organoid Against Liver Failure.

Yoshiki Kuse, Hideki Taniguchi

Cell transplantation, 28(1_suppl) 160S-165S, Dec, 2019 Peer-reviewed
Carteolol hydrochloride reduces visible light-induced retinal damage in vivo and BSO/glutamate-induced oxidative stress in vitro.

Masato Matsuo, Yoshiki Kuse, Kei Takahashi, Keiichi Kuwahara, Masaki Tanito, Sachiko Kaidzu, Masamitsu Shimazawa, Hideaki Hara, Akihiro Ohira

Journal of pharmacological sciences, 139(2) 84-90, Feb, 2019 Peer-reviewed
Potential effects of progranulin and granulins against retinal photoreceptor cell degeneration.

Miruto Tanaka, Yoshiki Kuse, Shinsuke Nakamura, Hideaki Hara, Masamitsu Shimazawa

Molecular vision, 25 902-911, 2019 Peer-reviewed
VGF nerve growth factor inducible is involved in retinal ganglion cells death induced by optic nerve crush.

Takeuchi H, Inagaki S, Morozumi W, Nakano Y, Inoue Y, Kuse Y, Mizoguchi T, Nakamura S, Funato M, Kaneko H …

Scientific reports, 8(1) 16443-16443, Nov, 2018 Peer-reviewed
Impaired Cerebellar Development in Mice Overexpressing VGF.

Mizoguchi T, Shimazawa M, Ohuchi K, Kuse Y, Nakamura S, Hara H

Neurochemical research, 44(2) 374-387, Nov, 2018 Peer-reviewed
Transient acceleration of autophagic degradation by pharmacological Nrf2 activation is important for retinal pigment epithelium cell survival

Yuichi Saito, Yoshiki Kuse, Yuki Inoue, Shinsuke Nakamura, Hideaki Hara, Masamitsu Shimazawa

Redox Biology, 19 354-363, Oct, 2018 Peer-reviewed
Intravitreal aflibercept protects photoreceptors of mice against excessive light exposure.

Kuse Y, Takahashi K, Inoue Y, Izawa H, Nakamura S, Shimazawa M, Hara H

Journal of pharmacological sciences, 137(4) 407-411, Aug, 2018 Peer-reviewed
Exposure to excessive blue LED light damages retinal pigment epithelium and photoreceptors of pigmented mice.

Nakamura M, Yako T, Kuse Y, Inoue Y, Nishinaka A, Nakamura S, Shimazawa M, Hara H

Experimental eye research, 177 1-11, Jul, 2018 Peer-reviewed
Microglia increases the proliferation of retinal precursor cells during postnatal development.

Yoshiki Kuse, Kazuki Ohuchi, Shinsuke Nakamura, Hideaki Hara, Masamitsu Shimazawa

Molecular vision, 24 536-545, 2018 Peer-reviewed
Bilberry extract and anthocyanins suppress unfolded protein response induced by exposure to blue LED light of cells in photoreceptor cell line.

Ooe E, Kuse Y, Yako T, Sogon T, Nakamura S, Hara H, Shimazawa M

Molecular vision, 24 621-632, 2018 Peer-reviewed
Progranulin increases phagocytosis by retinal pigment epithelial cells in culture

Hiromi Murase, Kazuhiro Tsuruma, Yoshiki Kuse, Masamitsu Shimazawa, Hideaki Hara

Journal of Neuroscience Research, 95(12) 2500-2510, Dec 1, 2017 Peer-reviewed
Platelet-derived growth factor-bb lessens light-induced rod photoreceptor damage in mice

Kei Takahashi, Masamitsu Shimazawa, Hiroshi Izawa, Yuki Inoue, Yoshiki Kuse, Hideaki Hara

Investigative Ophthalmology and Visual Science, 58(14) 6299-6307, Dec 1, 2017 Peer-reviewed
The Involvement of the Oxidative Stress in Murine Blue LED Light-Induced Retinal Damage Model

Maho Nakamura, Yoshiki Kuse, Kazuhiro Tsuruma, Masamitsu Shimazawa, Hideaki Hara

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 40(8) 1219-1225, Aug, 2017 Peer-reviewed
Molecular and cellular pharmacology Protective effects of fluoroquinolones on UV-induced damage of cultured ocular cell lines

Takashi Nishida, Yoshiki Kuse, Kiyofumi Mochizuki, Masamitsu Shimazawa, Tetsuya Yamamoto, Hideaki Hara

EUROPEAN JOURNAL OF PHARMACOLOGY, 806 59-66, Jul, 2017 Peer-reviewed
Astaxanthin analogs, adonixanthin and lycopene, activate Nrf2 to prevent light-induced photoreceptor degeneration

Yuki Inoue, Masamitsu Shimazawa, Ryota Nagano, Yoshiki Kuse, Kei Takahashi, Kazuhiro Tsuruma, Masahiro Hayashi, Takashi Ishibashi, Takashi Maoka, Hideaki Hara

JOURNAL OF PHARMACOLOGICAL SCIENCES, 134(3) 147-157, Jul, 2017 Peer-reviewed

Major Misc.

Developmental analysis aiming for the formation of tissue-like structure in human iPSC-derived liver organoid.

Yoshiki Kuse

38(11) 959-961, Oct, 2023 Peer-reviewedInvited

Research Projects

病態理解に向けたヒト血管の還流培養システムの開発

立松財団, Aug, 2023 - Aug, 2025

久世祥己
ヒト血管系の試験管内構築

公益財団法人G-7奨学財団, Apr, 2024 - Mar, 2025
ヒトミニ臓器を活用した生活習慣病予防戦略の開発

公益財団法人上原記念生命科学財団, Apr, 2024 - Mar, 2025
健康寿命延伸に向けたライフステージ早期における治療介入戦略の開発

令和５年度疾患別指定研究助成（鈴木謙三記念医科学応用研究財団）, Apr, 2024 - Mar, 2025

久世祥己
Induction of hepatic sinusoid formation in human iPSC-derived liver organoid based on the developmental process.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists, Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2025
ヒトミニ臓器を活用した成人病胎児起源説に基づく予防的治療戦略の開発

公益財団法人母子健康協会小児医学研究助成, Dec, 2023 - Nov, 2024
疾患モデル構築に向けたヒト血管の開発

東海産業技術振興財団, May, 2023 - May, 2024

久世祥己
令和5年度岐阜大学創薬シーズ共同研究助成

COMIT, Nov, 2023 - Mar, 2024
循環不全に伴う臓器機能障害機構の解明およびヒトオルガノイド培養系を活用した新規治療法の開発

川野小児医学奨学財団, Jun, 2023 - Mar, 2024

久世祥己
ヒト臓器創出を目指したiPS細胞オルガノイド培養技術プラットフォームの構築

科学研究費助成事業, 基盤研究(A), 日本学術振興会, Apr, 2021 - Mar, 2024

谷口英樹, 久世祥己, 村田聡一郎
階層的血管構造を有する3次元臓器の構築

再生医療実現拠点ネットワークプログラム, 国立研究開発法人日本医療研究開発機構, Jun, 2020 - Mar, 2023

田所友美, 久世祥己, 田中啓介, 山本優子
3D analysis of vascular formation during liver development

Grants-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists, Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Kuse Yoshiki
Liver organoid derived from iPSCs transplant to Cynomolgus monkey with liver cirrhosis

Grants-in-Aid for Scientific Research, Fund for the Promotion of Joint International Research (Fostering Joint International Research (B)), Japan Society for the Promotion of Science, Oct, 2018 - Mar, 2021

Taniguchi Hideki
Progranulinの網膜視細胞分化に関する研究

科学研究費助成事業, 特別研究員奨励費, 日本学術振興会, Apr, 2015 - Mar, 2018

久世祥己
公益財団法人池谷科学技術振興財団

公益財団法人池谷科学技術振興財団

Major Presentations

臓器形成メカニズム解析に向けた発生プロセスの3次元的理解

久世祥己, 谷口英樹

第23回日本再生医療学会総会, Mar 22, 2024
血流に連動した臓器形成メカニズム解析に向けた基礎的検討

久世祥己, 谷口英樹

生体機能と創薬シンポジウム2023, Aug 24, 2023
臓器発生における血管構築過程の３次元解析

久世祥己

第8回血管生物医学会若手研究会, May 27, 2023
血流開始後の臓器肥大メカニズム解析に向けた基礎的検討

久世祥己, Carolina Erica, 松本真弥, 田所友美, 上野康晴, 谷口英樹

第99回生理学会大会, Mar 16, 2022

Books and Other Publications

Progranulin and Central Nervous System Disorders

Kuse Y, Nakamura S, Hara H (Role: Contributor, New Therapeutic Approaches Against Ocular Diseases.)

Apr 2, 2019 (ISBN: 9811361851)
ブルーライトテキストブック

原英彰, 久世祥己 (Role: Contributor, ブルーライトが網膜の細胞障害を起こすメカニズム)

金原出版, Jun, 2016 (ISBN: 9784307351652)

Profile Information

Research Interests

Research Areas

Major Research History

Education

Awards

Papers

Major Misc.

Research Projects

Major Presentations

Books and Other Publications

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