論文

査読有り 国際誌
2020年5月19日

Recent advances in functional analysis of polyunsaturated fatty acid synthases.

Current opinion in chemical biology
  • Shohei Hayashi
  • ,
  • Yasuharu Satoh
  • ,
  • Yasushi Ogasawara
  • ,
  • Tohru Dairi

59
開始ページ
30
終了ページ
36
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.cbpa.2020.04.015

Polyunsaturated fatty acids (PUFAs) such as docosahexaenoic acid, eicosapentaenoic acid, and arachidonic acid are essential fatty acids for humans. PUFAs are biosynthesized by either desaturases/elongases from oleic acid or PUFA synthases from acetyl units. PUFA synthases are composed of three or four subunits, and each creates a specific PUFA even though the multiple catalytic domains in each subunit are very similar. We recently dissected these PUFA synthases by in vivo and in vitro experiments and elucidated how the enzymes control PUFA profiles. Moreover, for the first time, we converted a practical microalgal docosahexaenoic acid synthase into an eicosapentaenoic acid synthase based on the results.

リンク情報
DOI
https://doi.org/10.1016/j.cbpa.2020.04.015
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32442859

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