Sachiko Chikahisa

Profile Information

Affiliation: Okayama University of Science

Degree: 博士（医学）(Mar, 2007, 徳島大学大学院)

Researcher number: 00452649
J-GLOBAL ID: 201801004429482953
researchmap Member ID: B000322773

Research Interests

Research Areas

Research History

Apr, 2024 - Present

Okayama University of Science
Apr, 2022 - Mar, 2024

Shikoku University
Apr, 2017 - Mar, 2022

The University of Tokushima
Apr, 2015 - Mar, 2016

The University of Tokushima
Apr, 2007 - Mar, 2015

Institute of Health Biosciences The University of Tokushima Graduate School, The University of Tokushima
Sep, 2009 - Aug, 2010

客員助教（兼任）, 睡眠・生体リズム研究所, スタンフォード大学

Education

Apr, 2003 - Mar, 2007

徳島大学大学院医学研究科医学専攻
Apr, 2001 - Mar, 2003

徳島大学大学院人間・自然環境研究科人間環境専攻

Awards

Mar, 2021

徳島大学医学部 Best teacher of the year 2020, 徳島大学

Chikahisa Sachiko
May, 2019

First prize of poster competition (Graduate Research Category), Chronic mild stress exacerbates sleep quality and pain threshold, Philippine Dental Association

Dalanon Junhel, Chikahisa Sachiko, Afroz S, Iwasa Takuma, Waskitho Arief, Shimizu Noriyuki, Sei Hiroyoshi, Matsuka Yoshizo
Mar, 2017

徳島大学医学部 Best teacher of the year 2016, 徳島大学

Chikahisa Sachiko
Mar, 2011

徳島大学医学部岡奨学賞, 徳島大学

Chikahisa Sachiko
Mar, 2011

徳島大学医学部 Best teacher of the year 2010, 徳島大学

Chikahisa Sachiko
Mar, 2007

徳島大学医学部岡奨学賞, 徳島大学

Chikahisa Sachiko

Papers

Social stress alters sleep in FGF21-deficient mice.

Saori Hokari, Sachiko Chikahisa, Tetsuya Shiuchi, Yoshiaki Nakayama, Morichika Konishi, Seiji Nishino, Nobuyuki Itoh, Hiroyoshi Séi

Brain research bulletin, 191 40-47, Dec, 2022 Peer-reviewedCorresponding author
Dual orexin receptor antagonist drug suvorexant can help in amelioration of predictable chronic mild stress-induced hyperalgesia.

Parimal Chavan, Sachiko Chikahisa, Tetsuya Shiuchi, Noriyuki Shimizu, Junhel Dalanon, Kazuo Okura, Hiroyoshi Séi, Yoshizo Matsuka

Brain research bulletin, 188 39-46, Oct 1, 2022 Peer-reviewedCorresponding author
Feeding Rhythm-Induced Hypothalamic Agouti-Related Protein Elevation via Glucocorticoids Leads to Insulin Resistance in Skeletal Muscle.

Tetsuya Shiuchi, Airi Otsuka, Noriyuki Shimizu, Sachiko Chikahisa, Hiroyoshi Séi

International journal of molecular sciences, 22(19), Oct 7, 2021 Peer-reviewed
Pain sensitivity increases with sleep disturbance under predictable chronic mild stress in mice.

Junhel Dalanon, Sachiko Chikahisa, Tetsuya Shiuchi, Noriyuki Shimizu, Parimal Chavan, Yoshitaka Suzuki, Kazuo Okura, Hiroyoshi Séi, Yoshizo Matsuka

Scientific reports, 11(1) 14231-14231, Jul 9, 2021 Peer-reviewedCorresponding author
Intracranial mast cells contribute to the control of social behavior in male mice.

Daisuke Tanioka, Sachiko Chikahisa, Noriyuki Shimizu, Tetsuya Shiuchi, Noriaki Sakai, Seiji Nishino, Hiroyoshi Séi

Behavioural brain research, 403 113143-113143, Jan 28, 2021 Peer-reviewedCorresponding author
Sleep profile during fasting in PPAR-alpha knockout mice.

Yoshitsugu Kondo, Sachiko Chikahisa, Tetsuya Shiuchi, Noriyuki Shimizu, Daisuke Tanioka, Haruo Uguisu, Hiroyoshi Séi

Physiology & behavior, 214 112760-112760, Feb 1, 2020 Peer-reviewedLead authorCorresponding author
Rotigotine suppresses sleep-related muscle activity augmented by injection of dialysis patients’ sera in a mouse model of restless legs syndrome

Kazuhiro Muramatsu, Sachiko Chikahisa, Noriyuki Shimizu, Hiroyoshi Séi, Yuichi Inoue

Scientific Reports, 9(1) 16344, Dec, 2019 Peer-reviewedLead author
Dopamine stimulation of the septum enhances exercise efficiency during complicated treadmill running in mice.

Shiuchi T, Masuda T, Shimizu N, Chikahisa S, Séi H

The journal of physiological sciences : JPS, 69(6) 1019-1028, Nov, 2019 Peer-reviewed
Role of orexin in exercise-induced leptin sensitivity in the mediobasal hypothalamus of mice.

Shiuchi T, Miyatake Y, Otsuka A, Chikahisa S, Sakaue H, Séi H

Biochemical and biophysical research communications, 514(1) 166-172, Jun, 2019 Peer-reviewed
Enhancement of fear learning in PPAR knockout mice.

Sachiko Chikahisa, Daiki Chida, Tetsuya Shiuchi, Saki Harada, Noriyuki Shimizu, Airi Otsuka, Daisuke Tanioka, Hiroyoshi Sei

Behavioural Brain Research, 359 664-670, Feb, 2019 Peer-reviewedLead authorCorresponding author
Sufficient intake of high-fat food attenuates stress-induced social avoidance behavior.

Otsuka A, Shiuchi T, Chikahisa S, Shimizu N, Séi H

Life sciences, 219 219-230, Feb, 2019 Peer-reviewed
Mast cell involvement in glucose tolerance impairment caused by chronic mild stress with sleep disturbance

Sachiko Chikahisa, Saki Harada, Noriyuki Shimizu, Tetsuya Shiuchi, Airi Otsuka, Seiji Nishino, Hiroyoshi Sei

SCIENTIFIC REPORTS, 7(1) 13640, Oct, 2017 Peer-reviewedLead author
Wake-promoting effects of ONO-4127Na, a prostaglandin DP1 receptor antagonist, in hypocretin/orexin deficient narcoleptic mice

Yohei Sagawa, Masatoshi Sato, Noriaki Sakai, Sachiko Chikahisa, Shintaro Chiba, Takashi Maruyama, Junki Yamamoto, Seiji Nishino

NEUROPHARMACOLOGY, 110(Pt A) 268-276, Nov, 2016 Peer-reviewed
Late feeding in the active period decreases slow-wave activity

Kanna Oura, Airi Otsuka, Tetsuya Shiuchi, Sachiko Chikahisa, Noriyuki Shimizu, Hiroyoshi Sei

LIFE SCIENCES, 160 18-26, Sep, 2016 Peer-reviewed
Sleep as a biological problem: an overview of frontiers in sleep research

Takeshi Kanda, Natsuko Tsujino, Eriko Kuramoto, Yoshimasa Koyama, Etsuo A. Susaki, Sachiko Chikahisa, Hiromasa Funato

JOURNAL OF PHYSIOLOGICAL SCIENCES, 66(1) 1-13, Jan, 2016 Peer-reviewed
Voluntary exercise and increased food intake after mild chronic stress improve social avoidance behavior in mice

Airi Otsuka, Tetsuya Shiuchi, Sachiko Chikahisa, Noriyuki Shimizu, Hiroyoshi Sei

PHYSIOLOGY & BEHAVIOR, 151 264-271, Nov, 2015 Peer-reviewed
Ketone body metabolism and sleep homeostasis in mice

Sachiko Chikahisa, Noriyuki Shimizu, Tetsuya Shiuchi, Hiroyoshi Sei

NEUROPHARMACOLOGY, 79 399-404, Apr, 2014 Peer-reviewedLead author
Histamine from Brain Resident MAST Cells Promotes Wakefulness and Modulates Behavioral States

Sachiko Chikahisa, Tohru Kodama, Atsushi Soya, Yohei Sagawa, Yuji Ishimaru, Hiroyoshi Sei, Seiji Nishino

PLOS ONE, 8(10) e78434, Oct, 2013 Peer-reviewedLead author
Maternal Dietary Restriction Alters Offspring's Sleep Homeostasis

Noriyuki Shimizu, Sachiko Chikahisa, Yuina Nishi, Saki Harada, Yohei Iwaki, Hiroaki Fujihara, Kazuyoshi Kitaoka, Tetsuya Shiuchi, Hiroyoshi Sei

PLOS ONE, 8(5) e64263, May, 2013 Peer-reviewed
The retinoic acid receptor agonist Am80 increases hippocampal ADAM10 in aged SAMP8 mice

Kazuyoshi Kitaoka, Noriyuki Shimizu, Koji Ono, Sachiko Chikahisa, Madoka Nakagomi, Koichi Shudo, Kazunori Ishimura, Hiroyoshi Séi, Kazuo Yoshizaki

Neuropharmacology, 72 58-65, 2013 Peer-reviewed

Misc.

睡眠調節と脳内ケトン体代謝の関連性について

Chikahisa Sachiko

Seikagaku, Vol.93(No.2) 243-247, Apr 25, 2021 Peer-reviewed
ケトン体代謝と睡眠の最新知見

Chikahisa Sachiko

食と医療, Vol.15 28-35, Oct 28, 2020
肥満細胞の発現が社会行動へ及ぼす影響

谷岡大輔, 近久幸子, 清水紀之, 志内哲也, 大塚愛理, 勢井宏義

日本生理学雑誌, 81(2) 40-40, May, 2019
慢性ストレスにおける睡眠・代謝異常と肥満細胞の関係

谷岡大輔, 近久幸子, 原田紗希, 清水紀之, 志内哲也, 大塚愛理, 勢井宏義

日本生理学雑誌, 80(3) 40-40, Aug, 2018
性腺の摘出は睡眠を変化させる

谷岡大輔, 大上路生, 近久幸子, 清水紀之, 志内哲也, 大塚愛理, 勢井宏義

日本睡眠学会定期学術集会プログラム・抄録集, 43回 231-231, Jul, 2018
睡眠負債と代謝性疾患

近久幸子

睡眠医療, Vol. 12 369-373, 2018
ヒスタミンと睡眠調節 : ヒスタミン神経系とマスト細胞の役割 (特集アレルギー疾患と睡眠)

近久幸子, 勢井宏義

睡眠医療 : 睡眠医学・医療専門誌, 10(1) 35-42, 2016
-

Chikahisa Sachiko

Experimental Medicine, Vol.34 1276-1277, 2016
Physical exercise improve social interaction induced by social-defeated stress

Airi Otsuka, Tetsuya Shiuchi, Sachiko Chikahisa, Junji Terao, Hiroyoshi Sei

FASEB JOURNAL, 29, Apr, 2015
Contribution of PPAR alpha and Ketone Body to Sleep Homeostasis in Mice

Sachiko Chikahisa, Noriyuki Shimizu, Tetsuya Shiuchi, Hiroyoshi Sei

FASEB JOURNAL, 29, Apr, 2015
Exercise enhances following sleep in mice

Yu Yoshioka, Sachiko Chikahisa, Noriyuki Shimizu, Tetsuya Shiuchi, Hiroyuki Sei

FASEB JOURNAL, 29, Apr, 2015
Hypothalamic AgRP-mediated energy metabolism in skeletal muscle is a critical regulatory system in feeding rhythm-induced insulin resistance

Tetsuya Shiuchi, Airi Otsuka, Sachiko Chikahisa, Noriyuki Shimizu, Hiroyoshi Sei

FASEB JOURNAL, 29, Apr, 2015
Effect of feeding rhythm on sleep/wake regulation

K. Oura, T. Shiuchi, N. Shimizu, S. Chikahisa, H. Sei

DIABETOLOGIA, 56 S296-S296, Sep, 2013
Different feeding rhythm affects hypothalamic regulation of fatty acid metabolism in skeletal muscle

T. Shiuchi, S. Chikahisa, K. Oura, N. Shimizu, H. Sei

DIABETOLOGIA, 56 S308-S308, Sep, 2013
MALE ADULT MICE WITH LOW BIRTH WEIGHT SHOW AN INCREASED SLEEP PRESSURE

N. Shimizu, S. Chikahisa, Y. Iwaki, K. Kitaoka, H. Sei

SLEEP, 35 A50-A50, 2012
EFFECTS OF ICV ADMINISTARTION OF A MAST CELL HISTAMINE RELEASE ENHANCER ON SLEEP/WAKE IN WILD-TYPE AND MAST CELL DEFICIENT MICE

S. Chikahisa, T. Kodama, Y. Sagawa, Y. Ishimaru, H. Sei, S. Nishino

SLEEP, 35 A56-A57, 2012
Caloric restriction during pregnancy followed by low birth weight lead to elicit anxiety and depression in male offspring mice

Noriyuki Shimizu, Sachiko Chikahisa, Yohei Iwaki, Kazuyoshi Kitaoka, Hiroyoshi Sei

NEUROSCIENCE RESEARCH, 71 E396-E396, 2011
BRAIN RESIDENT MAST CELLS AFFECT SLEEP/WAKE PHYSIOLOGY AND PHARMACOLOGY

S. Chikahisa, Y. Sagawa, Y. Ishimaru, N. Sakai, M. Okuro, S. Nishino

SLEEP, 34 A45-A45, 2011
C57BL/6マウスにおいてカロリー制限により引き起こされる行動および遺伝子変化

山本悠太, 棚橋俊仁, 勝浦桜子, 黒川憲, 桑野由紀, 近藤茂忠, 六反一仁, 近久幸子, 勢井宏義

四国医学雑誌, 66(1-2) 49-49, Apr, 2010
Role of PPAR alpha in control of torpor through FGF21-NPY pathway: From circadian clock genes to seasonal change and cardiovascular disease

Norio K. Ishida, Daisuke Uchida, Ryosuke Doi, Katsutaka Oishi, Sachiko Chikahisa, Hiroyoshi Sei, Yasutaka Hamasaka, Takahiro Suzuki, Shuji Hanai

SLEEP AND BIOLOGICAL RHYTHMS, 8(1) 2-8, Jan, 2010

Books and Other Publications

サクセス管理栄養士・栄養士養成講座生化学

近久幸子 (Role: Contributor)

第一出版, Feb, 2024 (ISBN: 9784804114705)
睡眠学第2版

Chikahisa Sachiko (Role: Contributor, 第4章睡眠・覚醒調節の液性機構，4.3 アデノシン)

朝倉書店, Nov, 2020
睡眠障害知る診る治す

Sachiko Chikahisa (Role: Contributor, 2章睡眠のメカニズム，3章ノンレム・レム期の脳の働き，4章睡眠リズムの変化のメカニズム)

MEDICAL VIEW CO., LTD., Mar, 2014
脳とこころのプライマリ・ケア，第5巻意識と睡眠

近久幸子,西野精治 (Role: Contributor, 3章神経伝達物質と睡眠)

株式会社シナジー出版, Jun, 2012

Presentations

101

Effects of a dual orexin receptor antagonist drug on nociceptive behavior in predictable chronic mild stress: an animal study

Chavan P, Chikahisa Sachiko, Dalanon Junhel, Okura Kazuo, Matsuka Yoshizo

Asian Academy of Orofacial Pain and Temporomandibular Disorders, Oct 25, 2021
睡眠のホメオスタシスと脳内エネルギー代謝

近久幸子

第12回日本臨床睡眠医学会学術集会, Oct 23, 2021 Invited
Occupational stress and sleep quality of dentists in the Philippines

Dalanon Junhel, Diano LM, Fernandez I, Estalani CM, Te MP, Mana-ay C, Lagra E, Chikahisa Sachiko, Shimizu Noriyuki, Locsin Rozzano, Matsuka Yoshizo

International Association for Human Caring, Jun, 2021
Effects of dual orexin receptor antagonist drug on nociceptive behavior in predictable chronic mild stress mouse model

Parimal Chavan, Chikahisa Sachiko, Junhel Dalanon, Okura Kazuo, Matsuka Yoshizo

徳島大学脳科学ミニクラスター, Feb 23, 2021
Sleep-related muscle activity is augmented by administration of serum from RLS patients in Btbd9 mutant mice.

Chikahisa Sachiko, Muramatsu Kazuhiro, Shimizu Noriyuki, Sei Hiroyoshi, Inoue Yuichi

International RLS Study Group Meeting, Aug 29, 2020
Sleep loss impairs glucose tolerance in mice

Chikahisa Sachiko

Orofacial Pain Association of the Philippines, Jul 15, 2020 Invited
The effect of predictable chronic mild stress on sleep quality and nociception

Junhel Dalanon, Chikahisa Sachiko, Shimizu Noriyuki, Arief Waskitho, Parimal Chavan, Swarna Lakshmi, Sei Hiroyoshi, Ohshima Masamitsu, Matsuka Yoshizo

徳島大学脳科学クラスターミニリトリート, Feb 15, 2020
Orofacial thermal hyperalgesia in predictable chronic mild stress

Dalanon Junhel, Chikahisa Sachiko, Shimizu Noriyuki, Waskitho Arief, Sei Hiroyoshi, Matsuka Yoshizo

Asian Academy of Orofacial Pain and Temporomandibular Disorders, Oct 19, 2019
複雑な運動中の運動効率に及ぼすドーパミン作用

Shiuchi Tetsuya, 増田拓也, Shimizu Noriyuki, Chikahisa Sachiko, Sei Hiroyoshi

第74回日本体力医学会, Sep 19, 2019
妊娠期における摂食リズムの違いが仔における行動に及ぼす影響

Shiuchi Tetsuya, Shimizu Noriyuki, 大塚愛理, Chikahisa Sachiko, Sei Hiroyoshi

第6回時間栄養科学研究会, Aug 21, 2019
ケトン体代謝と睡眠調節

Chikahisa Sachiko

第6 回時間栄養科学研究会, Aug 21, 2019 Invited
Dopaminergic neuron activation via gut PPAR-alpha enhanced the motivation for wheel running in mice

Shiuchi Tetsuya, Hashimoto Keisuke, Hashimoto Ayaka, Otsuka Airi, Chikahisa Sachiko, Sei Hiroyoshi

NEURO2019, Jul 25, 2019
ローヤルゼリー摂取による自発運動への影響

Shiuchi Tetsuya, 大塚愛理, Chikahisa Sachiko, Sei Hiroyoshi

第73回日本栄養食糧学会, May 19, 2019
Chronic mild stress exacerbates sleep quality and pain threshold

Dalanon Junhel, Chikahisa Sachiko, Afroz S, Iwasa Takuma, Waskitho Arief, Shimizu Noriyuki, Sei Hiroyoshi, Matsuka Yoshizo

Philippine Dental Association, May 15, 2019
Role of dopaminergic function in septum on exercise efficiency

Shiuchi Tetsuya, Masuda Takuya, Shimizu Noriyuki, Chikahisa Sachiko, Sei Hiroyoshi

FAOSP2019, Mar 29, 2019
脳内エネルギー代謝と睡眠の相互作用

Chikahisa Sachiko

理化学研究所健康``生き活き''羅針盤リサーチコンプレックス主催セミナー, Nov 30, 2018
運動効率を高める中隔核でのドパミン作用

Shiuchi Tetsuya, 増田拓也, Shimizu Noriyuki, Chikahisa Sachiko, Sei Hiroyoshi

第73回日本体力医学会, Sep 9, 2018
Paternal psychological stress just before mating influences a formation of emotional behavior in next generation offspring mice

Noriyuki Shimizu, Sachiko Chikahisa, Tetsuya Shiuchi, Airi Otsuka, Daisuke Tanioka, Hiroyoshi Sei

The 41st Annual Meeting of the Japan Neuroscience Society, Jul 27, 2018
中隔核でのドパミン作用と運動効率の関係

増田拓也, Tetsuya Shiuchi, Sachiko Chikahisa, Noriyuki Shimizu, Hiroyoshi Sei

第41回日本神経科学学会大会, Jul 26, 2018
Social behavior is affected by mast cells activity in mice

Daisuke Tanioka, Sachiko Chikahisa, Noriyuki Shimizu, Tetsuya Shiuchi, Airi Otsuka, Hiroyoshi Sei

The 41st Annual Meeting of the Japan Neuroscience Society, Jul 26, 2018

Teaching Experience

Apr, 2022 - Mar, 2024

生化学実習 (四国大学)
Apr, 2022 - Mar, 2024

解剖生理学実習 (四国大学)
Apr, 2022 - Mar, 2024

生化学 (四国大学)
Apr, 2022 - Mar, 2024

解剖生理学 (四国大学)
Apr, 2022 - Mar, 2024

解剖生理学 (徳島県立総合看護学校)
Apr, 2017 - Mar, 2022

生理学 (徳島大学)
Apr, 2007 - Mar, 2022

生理学実習 (徳島大学)

Professional Memberships

Research Projects

慢性不眠に起因する痛覚過敏の理解と創薬応用

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2024 - Mar, 2028

近久幸子
骨格筋代謝によるストレスレジリエンス強化機序の解明

科学研究費助成事業, 基盤研究(B), 日本学術振興会, Apr, 2022 - Mar, 2026

志内哲也, 近久幸子
睡眠不足が引き起こす行動異常の分子機序解明と予防法の確立

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2021 - Mar, 2024

近久幸子
慢性不眠に起因する代謝異常発症の責任分子カスケードの同定と創薬基盤の構築

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

近久幸子
睡眠・運動・代謝における相互的中枢−末梢連関

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2018

勢井宏義
Central ketone body and brain function including sleep regulation

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

CHIKAHISA Sachiko
The role of lipid metabolism in brain functions and sleep

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2014

CHIKAHISA Sachiko
Central action of lipid metabolism in the brain

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2009 - Mar, 2011

CHIKAHISA Sachiko
Pathophysilogy in evening-type : Observation in Clockmutant mice

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2006 - Mar, 2008

佐野敦子

Profile Information

Research Interests

Research Areas

Research History

Education

Awards

Papers

Misc.

Books and Other Publications

Presentations

Teaching Experience

Professional Memberships

Research Projects

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Coauthors