Apr, 2011 - Mar, 2015
Comparison Western Japan with Eastern Japan about the cause of asymptomatic cerebrovascular disorders and hippocampal atrophy in general Japanese men
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A) Grant-in-Aid for Scientific Research (A)
- Grant number
- 23249036
- Japan Grant Number (JGN)
- JP23249036
- Grant amount
-
- (Total)
- 47,190,000 Japanese Yen
- (Direct funding)
- 36,300,000 Japanese Yen
- (Indirect funding)
- 10,890,000 Japanese Yen
Stroke mortality is low in the Western Japan, while high in the Eastern Japan. In this study, we performed brain magnetic resonance imaging (MRI) in participants of cohort studies at Kusatsu (west) and Ohasama (east). First, we conducted MRI in same participants living in Ohasama at both Kusatsu and Ohasama facilities to investigate validity comparing West and East. Kappa coefficients between two facilities were about 0.60 in lacunar infarction and cerebral microbleed, 0.46 in white matter lesion. Then, we compared people in Kusatsu with these in Ohasama aged from 60 to 89 by age. Prevalence of lacunar infarction and that of cerebral microbleed were higher in Ohasama than in Kusatsu, and we thought that it might be occurred because people in Ohasama had higher blood pressure and percentage of medication of hypertension than Kusatsu in baseline characteristics. Meanwhile prevalence of white matter lesion was higher in Kusatsu than in Ohasama. That reason was not clear.
- Link information
- ID information
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- Grant number : 23249036
- Japan Grant Number (JGN) : JP23249036