2023年
Identifying miRNA-Gene Common and Specific Regulatory Modules for Cancer Subtyping by a High-Order Graph Matching Model.
IEEE ACM Trans. Comput. Biol. Bioinform.
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- 巻
- 20
- 号
- 1
- 開始ページ
- 421
- 終了ページ
- 431
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1109/TCBB.2022.3161635
Identifying regulatory modules between miRNAs and genes is crucial in cancer research. It promotes a comprehensive understanding of the molecular mechanisms of cancer. The genomic data collected from subjects usually relate to different cancer statuses, such as different TNM Classifications of Malignant Tumors (TNM) or histological subtypes. Simple integrated analyses generally identify the core of the tumorigenesis (common modules) but miss the subtype-specific regulatory mechanisms (specific modules). In contrast, separate analyses can only report the differences and ignore important common modules. Therefore, there is an urgent need to develop a novel method to jointly analyze miRNA and gene data of different cancer statuses to identify common and specific modules. To that end, we developed a High-Order Graph Matching model to identify Common and Specific modules (HOGMCS) between miRNA and gene data of different cancer statuses. We first demonstrate the superiority of HOGMCS through a comparison with four state-of-the-art techniques using a set of simulated data. Then, we apply HOGMCS on stomach adenocarcinoma data with four TNM stages and two histological types, and breast invasive carcinoma data with four PAM50 subtypes. The experimental results demonstrate that HOGMCS can accurately extract common and subtype-specific miRNA-gene regulatory modules, where many identified miRNAgene interactions have been confirmed in several public databases.
- リンク情報
- ID情報
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- DOI : 10.1109/TCBB.2022.3161635
- DBLP ID : journals/tcbb/ChenHXAC23
- PubMed ID : 35320104