Takeo Saneyoshi

Profile Information

Affiliation: Professor, School of Life Science and Technology, Tokyo Institute of Technology

Degree: 博士（医学）(東京大学)

J-GLOBAL ID: 201601014020308170
researchmap Member ID: 7000017656

Research Areas

Life sciences / Neuroscience - general /

Research History

Apr, 2024 - Present

Professor, School of Life Science and Technology, Tokyo Institute of Technology

Papers

FAM81A is a postsynaptic protein that regulates the condensation of postsynaptic proteins via liquid-liquid phase separation.

Takeshi Kaizuka, Taisei Hirouchi, Takeo Saneyoshi, Toshihiko Shirafuji, Mark O Collins, Seth G N Grant, Yasunori Hayashi, Toru Takumi

PLoS biology, 22(3) e3002006, Mar, 2024
Engineering memory with an extrinsically disordered kinase.

Cristian Ripoli, Onur Dagliyan, Pietro Renna, Francesco Pastore, Fabiola Paciello, Raimondo Sollazzo, Marco Rinaudo, Martina Battistoni, Sara Martini, Antonella Tramutola …

Science advances, 9(46) eadh1110, Nov 17, 2023 Peer-reviewed
Changing the size of dendritic spines.

Takeo Saneyoshi

eLife, 12, Sep 7, 2023 Lead authorLast authorCorresponding author
CaMKII binds both substrates and activators at the active site.

Can Özden, Roman Sloutsky, Tomohiro Mitsugi, Nicholas Santos, Emily Agnello, Christl Gaubitz, Joshua Foster, Emily Lapinskas, Edward A Esposito, Takeo Saneyoshi …

Cell reports, 40(2) 111064-111064, Jul 12, 2022 Peer-reviewed
Shootin1a-mediated actin-adhesion coupling generates force to trigger structural plasticity of dendritic spines.

Ria Fajarwati Kastian, Takunori Minegishi, Kentarou Baba, Takeo Saneyoshi, Hiroko Katsuno-Kambe, Singh Saranpal, Yasunori Hayashi, Naoyuki Inagaki

Cell reports, 35(7) 109130-109130, May 18, 2021 Peer-reviewed
Reciprocal activation within a kinase effector complex: A mechanism for the persistence of molecular memory.

Takeo Saneyoshi

Brain research bulletin, 170 58-64, May, 2021 Peer-reviewedLead authorLast authorCorresponding author
Amyloid-β-Dependent Neuronal Circuit Rearrangement in Presymptomatic Alzheimer's Disease.

Mizuta K, Saneyoshi T

Biological psychiatry, 86(3) 167-168, Aug, 2019 Peer-reviewedLast authorCorresponding author
The role of CaMKII-Tiam1 complex on learning and memory.

Kojima H, Rosendale M, Sugiyama Y, Hayashi M, Horiguchi Y, Yoshihara T, Ikegaya Y, Saneyoshi T, Hayashi Y

Neurobiology of learning and memory, 166 107070-107070, Aug, 2019 Peer-reviewedCorresponding author
Reciprocal Activation within a Kinase-Effector Complex Underlying Persistence of Structural LTP.

Saneyoshi T, Matsuno H, Suzuki A, Murakoshi H, Hedrick NG, Agnello E, O'Connell R, Stratton MM, Yasuda R, Hayashi Y

Neuron, 102(6) 1199-1210.e6, Jun, 2019 Peer-reviewedLead authorCorresponding author
Design, Synthesis, and Cellular Uptake of Oligonucleotides Bearing Glutathione-Labile Protecting Groups.

Hisao Saneyoshi, Takayuki Ohta, Yuki Hiyoshi, Takeo Saneyoshi, Akira Ono

Organic letters, 21(4) 862-866, Feb 15, 2019 Peer-reviewed
ERK5 Phosphorylates K_v4.2 and Inhibits Inactivation of the A-Type Current in PC12 Cells.

Kashino Y, Obara Y, Okamoto Y, Saneyoshi T, Hayashi Y, Ishii K

International journal of molecular sciences, 19(7), Jul, 2018 Peer-reviewed
CaMKII biophysics and its role in long-term potentiation

Margaret Stratton, Ana Torres, Yasunori Hayashi, Takeo Saneyoshi, Emily Agnello, Rory O'connell, Brendan Page, Megan West

PROTEIN SCIENCE, 26 77-77, Dec, 2017 Peer-reviewed
Interplay of enzymatic and structural functions of CaMKII in long-term potentiation

Karam Kim, Takeo Saneyoshi, Tomohisa Hosokawa, Kenichi Okamoto, Yasunori Hayashi

JOURNAL OF NEUROCHEMISTRY, 139(6) 959-972, Dec, 2016 Peer-reviewed
Synthesis and Characterization of Cell-Permeable Oligonucleotides Bearing Reduction-Activated Protecting Groups on the internucleotide Linkages

Hisao Saneyoshi, Koichi Iketani, Kazuhiko Kondo, Takeo Saneyoshi, Itaru Okamoto, Akira Ono

BIOCONJUGATE CHEMISTRY, 27(9) 2149-2156, Sep, 2016 Peer-reviewed
A Naturally Occurring Null Variant of the NMDA Type Glutamate Receptor NR3B Subunit Is a Risk Factor of Schizophrenia

Hitomi Matsuno, Kazutaka Ohi, Ryota Hashimoto, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Satomi Yano-Umeda, Takeo Saneyoshi, Masatoshi Takeda, Yasunori Hayashi

PLOS ONE, 10(3) e0116319, Mar, 2015 Peer-reviewed
Synapse reorganization-a new partnership revealed

Takeo Saneyoshi, Yasunori Hayashi

EMBO JOURNAL, 33(12) 1292-1294, Jun, 2014 Peer-reviewedLead author
Structural and Molecular Remodeling of Dendritic Spine Substructures during Long-Term Potentiation

Miquel Bosch, Jorge Castro, Takeo Saneyoshi, Hitomi Matsuno, Mriganka Sur, Yasunori Hayashi

NEURON, 82(2) 444-459, Apr, 2014 Peer-reviewed
The Ca2+ and Rho GTPase signaling pathways underlying activity-dependent actin remodeling at dendritic spines

Takeo Saneyoshi, Yasunori Hayashi

CYTOSKELETON, 69(8) 545-554, Aug, 2012 Peer-reviewedLead author
Calmodulin-kinases regulate basal and estrogen stimulated medulloblastoma migration via Rac1

Monika A. Davare, Takeo Saneyoshi, Thomas R. Soderling

JOURNAL OF NEURO-ONCOLOGY, 104(1) 65-82, Aug, 2011 Peer-reviewed
Regulation of spine and synapse formation by activity-dependent intracellular signaling pathways

Takeo Saneyoshi, Dale A. Fortin, Thomas R. Soderling

CURRENT OPINION IN NEUROBIOLOGY, 20(1) 108-115, Feb, 2010 Peer-reviewedLead author

Misc.

【シナプス】シナプス可塑性シナプスとアクチンシグナル

實吉岳郎, 林康紀

生体の科学, 74(1) 62-66, Feb, 2023 Lead author
記憶分子再考：CaMKIIの新しい活性制御

實吉岳郎

細胞, 51(14) 706-709, Dec, 2019 InvitedLead authorLast authorCorresponding author
Activity-dependent synaptogenesis: Regulation by a CaM-KK/CaM-KI/bPIX signaling complex

Takeo Saneyoshi, Gary Wayman, Dale Fortin, Monika Davare, Naoto Hoshi, Naohito Nozaki, Tohru Natsume, Thomas Soderling

NEUROSCIENCE RESEARCH, 61 S234-S234, 2008

Research Projects

記憶形成に伴うシナプスタンパク質の集積・維持の制御機構

科学研究費助成事業基盤研究(B), 基盤研究(B), 日本学術振興会, Apr, 2021 - Mar, 2024

実吉岳郎
シナプスタンパク質の生物学的相分離の操作による可塑性、臨界期誘導法の開発

科学研究費助成事業学術変革領域研究(A), 学術変革領域研究(A), 日本学術振興会, Sep, 2021 - Mar, 2023

実吉岳郎
Molecular mechanisms of signaling molecule condensation by liquid-liquid phase separation for memory maintenance

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory), Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jul, 2020 - Mar, 2022

Saneyoshi Takeo
A reciprocal-activation-within-a-kinase-effector-complex regulates formation and maintenance of memory

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

Saneyoshi Takeo
Generation of photoactivatable transcription molecules to control memory formation

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory), Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2018 - Mar, 2020

Saneyoshi Takeo
二光子顕微鏡による光刺激と二重FRET観察技術の開発とシナプス構造可塑性の解析

科学研究費助成事業新学術領域研究(研究領域提案型), 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2013 - Mar, 2015

実吉岳郎
Positive feedback loop of Rac activity on synapse structural plasticity

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (A), Grant-in-Aid for Young Scientists (A), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015

SANEYOSHI Takeo
Identification of cellular substrate for CaMKII using unnatural amino acid incorporation

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2014

SANEYOSHI Takeo
光活性化蛋白質を用いた二光子機能イメージング法の開発とシナプス構造可塑性の解析

科学研究費助成事業新学術領域研究(研究領域提案型), 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2011 - Mar, 2013

実吉岳郎
Regulation of synaptic structural plasticity : Involvement of Rho family GTPases by photoactivatable proteins

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2010 - 2011

SANEYOSHI Takeo
初期胚における腹側化シグナルとしてのIP3-Ca2+シグナル伝達系の作用機序

科学研究費助成事業特別研究員奨励費, 特別研究員奨励費, 日本学術振興会, 1999 - 2001

実吉岳郎

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