2020年6月25日
Harnessing Chalcogen-bonding Interactions To Establish Conformational Control in Dirhodium(II) Paddlewheel Complexes
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- DOI
- 10.26434/chemrxiv.12547262.v1
- 出版者・発行元
- American Chemical Society (ACS)
Novel well-defined <i>D</i><sub>2</sub>-symmetric dirhodium(II) carboxylate complexes that bear axially chiral binaphthothiophene delta-amino acid derivatives have been developed. Conformational control was achieved through chalcogen-bonding interactions between sulfur and oxygen atoms in each ligand, providing well-defined and uniform asymmetric environments around the catalytically active Rh(II) centers. These structural properties render such complexes excellent catalysts for the inside-type asymmetric intramolecular C–H insertion into alpha-aryl-alpha-diazoacetates to yield a variety of <i>cis</i>- alpha, beta-diaryl gamma-lactones, as well as the corresponding <i>trans</i>-isomers through epimerization, in high diastereo- and enantioselectivities. Short total syntheses of the naturally occurring gamma-lactones cinnamomumolide, cinncassin A<sub>7</sub>, and cinnamomulactone were also accomplished using this conformationally controlled catalyst.<br><br>
- リンク情報
- ID情報
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- DOI : 10.26434/chemrxiv.12547262.v1