1990年12月
GENE DUPLICATION AND CONCERTED EVOLUTION OF THE GPDH LOCUS IN NATURAL-POPULATIONS OF DROSOPHILA-MELANOGASTER
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
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- 巻
- 242
- 号
- 1305
- 開始ページ
- 157
- 終了ページ
- 162
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1098/rspb.1990.0119
- 出版者・発行元
- ROYAL SOC
The sn-glycerol-3-phosphate dehydrogenase (GPDH, EC 1, 1, 1, 8) locus of Drosophila melanogaster is polymorphic with respect to the number of tandemly duplicated genes in natural populations. The duplicated genes were cloned and the nucleotide sequences were determined. The duplication deletes both the first and second exons and has a size of 4500 b.p. The fact that there is no sequence variation at the junction point of the duplicated units among strains suggests a single origin for the duplication event. Comparison of the nucleotide sequences among the duplicates indicates that the frequent transfer of genetic information occurs from one to the other of the duplicates on the same chromosome either by gene conversion or by unequal crossing over. Because the GPDH duplication is partial and therefore a kind of pseudogene, the observed polymorphism of the number of tandemly duplicated GPDH genes appears to have been driven mainly by random genetic drift.
- リンク情報
- ID情報
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- DOI : 10.1098/rspb.1990.0119
- ISSN : 0962-8452
- eISSN : 1471-2954
- PubMed ID : 1983032
- Web of Science ID : WOS:A1990ET33600003