Hiroyuki Koike

J-GLOBAL         Last updated: Sep 26, 2019 at 09:07
 
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Name
Hiroyuki Koike
Affiliation
Nippon Medical School
Section
Department of Biochemistry & Molecular Biology
Job title
Assistant Professor
Degree
Ph.D.(Yokohama City University)

Research Areas

 
 

Academic & Professional Experience

 
Apr 2019
 - 
Today
Assistant Professor, Department of Biochemistry and Molecular Biology, Nippon Medical School
 
Mar 2018
 - 
Mar 2019
Assistant Professor, Medical Research Institute, Tokyo Medical and Dental University
 
Nov 2015
 - 
Feb 2018
Research Fellow, Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center
 
Apr 2014
 - 
Nov 2015
Postdoctoral Fellow, Institute of Stem Cell Biology and Regenerative Medicine, Stanford University
 
Apr 2009
 - 
Mar 2010
R&D, Material Business, Teijin Limited
 

Education

 
Apr 2010
 - 
Mar 2014
Department of Regenerative Medicine, Graduate School of Medicine, Yokohama City University
 
Apr 2007
 - 
Mar 2009
Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University
 
Apr 2003
 - 
Mar 2007
Department of Applied Chemistry, School of Engineering, Tohoku University
 

Awards & Honors

 
Sep 2019
Maruyama Memorial Research Award, Nippon Medical School
 
Sep 2018
Young Investigator Award from President, Tokyo Medical and Dental University
 
Aug 2016
Core Values Award, Cincinnati Children’s Hospital Medical Center
 
Mar 2014
Excellent Article Award, Yokohama City University
 

Published Papers

 
Koike H, Iwasawa K, Ouchi R, Maezawa M, Giesbrecht K, Saiki N, Ferguson A, Kimura M, Thompson WL, Wells JM, Zorn AM, Takebe T
Nature      Sep 2019   [Refereed]
Organogenesis is a complex and interconnected process that is orchestrated by multiple boundary tissue interactions. However, it remains unclear how individual, neighbouring components coordinate to establish an integral multi-organ structure. Her...
Ouchi R, Togo S, Kimura M, Shinozawa T, Koido M, Koike H, Thompson W, Karns RA, Mayhew CN, McGrath PS, McCauley HA, Zhang RR, Lewis K, Hakozaki S, Ferguson A, Saiki N, Yoneyama Y, Takeuchi I, Mabuchi Y, Akazawa C, Yoshikawa HY, Wells JM, Takebe T
Cell metabolism      May 2019   [Refereed]
Ong J, Serra MP, Segal J, Cujba AM, Ng SS, Butler R, Millar V, Hatch S, Zimri S, Koike H, Chan K, Bonham A, Walk M, Voss T, Heaton N, Mitry R, Dhawan A, Ebner D, Danovi D, Nakauchi H, Rashid ST
Stem cell reports   10(3) 693-702   Mar 2018   [Refereed]
Koike H, Zhang RR, Ueno Y, Sekine K, Zheng YW, Takebe T, Taniguchi H
Development (Cambridge, England)   144(6) 1018-1024   Mar 2017   [Refereed]
Takebe T, Enomura M, Yoshizawa E, Kimura M, Koike H, Ueno Y, Matsuzaki T, Yamazaki T, Toyohara T, Osafune K, Nakauchi H, Yoshikawa HY, Taniguchi H
Cell stem cell   16(5) 556-565   May 2015   [Refereed]
Koike H, Ueno Y, Naito T, Shiina T, Nakata S, Ouchi R, Obana Y, Sekine K, Zheng YW, Takebe T, Isono K, Koseki H, Taniguchi H
Hepatology (Baltimore, Md.)   60(1) 323-333   Jul 2014   [Refereed]
Takebe T, Zhang RR, Koike H, Kimura M, Yoshizawa E, Enomura M, Koike N, Sekine K, Taniguchi H
Nature protocols   9(2) 396-409   Feb 2014   [Refereed]
Koike H, Ouchi R, Ueno Y, Nakata S, Obana Y, Sekine K, Zheng YW, Takebe T, Isono K, Koseki H, Taniguchi H
PloS one   9(8) e104776   Aug 2014   [Refereed]
Zhang RR, Takebe T, Miyazaki L, Takayama M, Koike H, Kimura M, Enomura M, Zheng YW, Sekine K, Taniguchi H
Methods in molecular biology (Clifton, N.J.)   1210 131-141   2014   [Refereed]
Takebe T, Sekine K, Enomura M, Koike H, Kimura M, Ogaeri T, Zhang RR, Ueno Y, Zheng YW, Koike N, Aoyama S, Adachi Y, Taniguchi H
Nature   499(7459) 481-484   Jul 2013   [Refereed]

Misc

 
Hiroyuki Koike, Takanori Takebe
Current Pathobiology Reports   4(2) 59-68   Jun 2016
小池博之, 武部貴則
自動車技術   69(11) 108-109   Nov 2015
大崎達哉, 福田淳二, 小池博之, 武部貴則
実験医学   33(8) 1259-1265   May 2015
Koike H, Taniguchi H
Journal of hepato-biliary-pancreatic sciences   19(6) 587-593   Nov 2012   [Refereed]
谷口英樹, 小池博之
実験医学   29(20) 3254-3261,3220(1)-3220(2)   Dec 2011
小池 博之, 中田 晋, 谷口 英樹
臨床検査   55(5) 495-499   May 2011

Books etc

 
Ran-Ran Zhang, Hiroyuki Koike, Takanori Takebe (Part:Contributor, The Visualization of Human Organogenesis from Stem Cells by Recapitulating Multicellular Interactions)
Springer Japan   Jul 2015   ISBN:9784431552963
Hiroyuki Koike, Tamir Rashid, Takanori Takebe (Part:Contributor, Growing Mini‐Organs from Stem Cells)
Wiley-VCH Verlag   Nov 2016   ISBN:9783527305421

Conference Activities & Talks

 
Zinc-finger transcription factor KLF5 is involved in the pathogenesis of muscle atrophy 
Lin Liu, Hiroyuki Koike, Shinichiro Hayashi, Hiroshi Asahara, Yumiko Oishi
The 5th Annual Meeting of Japan Muscle Society   3 Aug 2019   Japan Muscle Society
時計遺伝子 Bmal1 欠損によるマクロファージ形質変化の阻害は 筋再生を遅延させる
Aiko Watanabe, Hiroyuki Koike, Yumiko Oishi
The 5th Annual Meeting of Japan Muscle Society   2 Aug 2019   Japan Muscle Society
Zn-finger transcription factor Klf5 is involved in the pathogenesis of muscle atrophy in vivo.
Lin Liu, Hiroyuki Koike, Yumiko Oishi
The 41st Annual Meeting of the Molecular Biology Society of Japan   28 Nov 2018   
Shodai Togo, Rie Ouchi, Tadahiro Shinozawa, Hiroyuki Koike, Hiroshi Yoshikawa, Takanori Takebe
The 65th JSAP Spring Meeting   18 Mar 2018   The Japan Society of Applied Physics
ミニ肝臓を用いた脂肪酸蓄積による臓器構造・機能の時空間ダイナミクスの解明
Shodai Togo, Rie Ouchi, Tadahiro Shinozawa, Hiroyuki Koike, Hiroshi Yoshikawa, Takanori Takebe
7th CSJ Chemistry Festa   17 Oct 2017   
Shodai Togo, Rie Ouchi, Tadahiro Shinozawa, Hiroyuki Koike, Hiroshi Y. Yoshikawa, Takanori Takebe
The 78th JSAP Autumn Meeting, 2017   5 Sep 2017   The Japan Society of Applied Physics
Anterior-posterior gut boundary interaction initiate hepatic specification program from human iPSC. [Invited]
Hiroyuki Koike
Endoderm Club Research Seminar   18 Apr 2017   Cincinnati Children’s Hospital Medical Center
Sequential boundary interaction initiate multi-organ budding program from iPSC
Hiroyuki Koike, Takanori Takebe
Digestive Health Center Annual Scientific Retreat   28 Feb 2017   Cincinnati Children’s Hospital Medical Center
in vitro human NAFLD model using human iPSC derived liver organoids.
Rie Ouchi, Tadahiro Shinozawa, Shodai Togo, Hiroyuki Koike, Takanori Takebe
The Japan-US Science Forum in Boston   12 Nov 2016   Japan Society for the Promotion of Science
Modeling early human organogenesis using iPSCs.
Hiroyuki Koike
Liver Research Round Table Discussion   24 Oct 2016   Cincinnati Children’s Hospital Medical Center
Modeling early human organogenesis using iPSCs.
Hiroyuki Koike
Endoderm Club Research Seminar   1 May 2016   Cincinnati Children’s Hospital Medical Center
Modeling multi-organ budding from human iPSCs.
Hiroyuki Koike
Developmental Mechanisms, Organogenesis and Stem Cells Annual Retreat 2016   1 Apr 2016   Cincinnati Children’s Hospital Medical Center
Design of Mechanically Patterned Hydrogel for Directing Organ Bud Self-Formation
Yuko Shimokawa, Hiroyuki Koike, Takahisa Matsuzaki, Masahiro Enomura, Masaki Kimura, Seiichiro Nakabayashi, Hiromitsu Nakauchi, Hideki Taniguchi, Takanori Takebe, Hiroshi Y. Yoshikawa
Pacifichem 2015   15 Dec 2015   Pacific Basin Chemical Societies
Yuko Shimokawa, Hiroyuki Koike, Takahisa Matsuzaki, Masahiro Enomura, Masaki Kimura, Seiichiro Nakabayashi, Hiromitsu Nakauchi, Hideki Taniguchi, Takanori Takebe, Hiroshi Y. Yoshikawa
The 53rd Annual Meeting of the Biophysical Society of Japan   13 Sep 2015   The Biophysical Society of Japan
Modeling liver organogenesis in culture
Hiroyuki Koike
Stem Cell Club   1 Jun 2015   Stanford University
Valine supplement stimulates expansion of human iPSC-derived hepatic progenitor cells
Hiroyuki Koike, Ran-Ran Zhang, Yasuharu Ueno, Takanori Takebe, Hideki Taniguchi
The 18th Takeda Science Foundation Symposium on Bioscience   15 Jan 2015   Takeda Science Foundation
Reina Miyazaki, Takanori Takebe, Maho Takayama, Masaki Kimura, Hiroyuki Koike, Masahiro Enomura, Fumika Kawamata, Keisuke Sekine, Hideki Taniguchi
The 13th Congress of the Japanese Society for Regenerative Medicine   6 Mar 2014   The Japanese Society for Regenerative Medicine
Hinatsu Ohgane, Takanori Takebe, Hiroyuki Koike, Fumika Kawamata, Masaki Kimura, Keisuke Sekine, Hideki Taniguchi
The 13th Congress of the Japanese Society for Regenerative Medicine   5 Mar 2014   The Japanese Society for Regenerative Medicine
Localization of repressive histone marks and target genes dynamically switch through murine hepatic differentiation
Susumu Nakata, Yasuharu Ueno, Hiroyuki Koike, Keisuke Sekine, Hideki Taniguchi
The 72nd Annual Meeting of the Japanese Cancer Association   3 Oct 2013   The Japanese Cancer Association
Creation of vascularized and functional human liver from an induced pluripotent stem cell-derived organ bud transplant
Takanori Takebe, Keisuke Sekine, Masahiro Enomura, Hiroyuki Koike, RanRan Zhang, Masaki Kimura, Takunori Ogaeri, Emi Yoshizawa, Fumika Kawamata, Naoto Koike, Yasuharu Ueno, Yun-Wen Zheng, Hideki Taniguchi
The 13th Congress of the Asian Society of Transplantation   3 Sep 2013   The Asian Society of Transplantation

Research Grants & Projects

 
骨格筋の恒常性維持を担う筋衛星細胞-マクロファージ間の相互作用解析
Japan Society for the Promotion of Science: Grant-in-Aid for Early-Career Scientists
Project Year: Apr 2019 - Mar 2021    Investigator(s): Hiroyuki Koike
Study of the muscle satellite cell-macrophage crosstalk and skeletal muscle regeneration
Japan Society for the Promotion of Science: Grant-in-Aid for Research Activity start-up
Project Year: Aug 2018 - Mar 2019    Investigator(s): Hiroyuki Koike

Patents

 
WO/2018/226267 : LIVER ORGANOID COMPOSITIONS AND METHODS OF MAKING AND USING SAME
Takanori Takebe, Tadahiro Shinozawa, Hiroyuki Koike, Masaki Kimura
谷口 英樹, 武部 貴則, 上野 康晴, 小池 博之
谷口 英樹, 武部 貴則, 上野 康晴, 小池 博之
WO/2018/085615 : LIVER ORGANOID COMPOSITIONS AND METHODS OF MAKING AND USING SAME
Takanori Takebe, Tadahiro Shinozawa, Masaki Kimura, Hiroyuki Koike