1998年1月
Albutensin A, an ileum-contracting peptide derived from serum albumin, acts through both receptors for complements C3a and C5a
LETTERS IN PEPTIDE SCIENCE
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- 巻
- 5
- 号
- 1
- 開始ページ
- 29
- 終了ページ
- 35
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1023/A:1008816314979
- 出版者・発行元
- SPRINGER
Albutensin A is an ileum-contracting peptide derived from serum albumin. The sequences of bovine, human and porcine albutensin A are ALKAWSVAR, AFKAWAVAR, and AFKAWSLAR, respectively. These albutensin A homologs all exhibited biphasic ileal contractions in the longitudinal strips of guinea pig ileum. The order of potency in the contraction was porcine > bovine > human homologs. The ileal contraction profiles were similar to those of oryzatensin and casoxin C, agonist peptides for complement C3a receptors derived from rice albumin and bovine kappa-casein, respectively. All three homologs of albutensin A have homology with the COOH-terminal sequences of complements C3a and C5a, which are essential for their activities; porcine albutensin A showed the highest homology. Indeed, porcine albutensin A was confirmed to act through both C3a and C5a receptors by a radioreceptor assay and cross-desensitization in the ileal contraction. In addition, bovine and human homologs also showed affinity for both receptors. This study suggests that a bioactive peptide acting through both C3a and C5a receptors is released by the proteolytic cleavage of serum proteins other than complement components.
- リンク情報
- ID情報
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- DOI : 10.1023/A:1008816314979
- ISSN : 0929-5666
- J-Global ID : 200902171205536605
- Web of Science ID : WOS:000073431500005