2010年9月
Enhanced in vivo Magnetic Resonance Imaging of Tumors by PEGylated Iron-Oxide-Gold Core-Shell Nanoparticles with Prolonged Blood Circulation Properties
MACROMOLECULAR RAPID COMMUNICATIONS
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- 巻
- 31
- 号
- 17
- 開始ページ
- 1521
- 終了ページ
- 1528
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/marc.201000341
- 出版者・発行元
- WILEY-V C H VERLAG GMBH
High-density poly(ethylene glycol) (PEG)-coated iron-oxide-gold core-shell nanoparticles (AuIONs) were developed as T(2)-weighted magnetic resonance imaging (MRI) contrast agents for cancer imaging. The PEG-coated iron-oxide-gold core-shell nanoparticles (PEG-AuIONs) were approximately 25 nm in diameter with a narrow distribution. Biodistribution experiments in mice bearing a subcutaneous colon cancer model prepared with C26 murine colon adenocarcinoma cells showed high accumulation of the PEG-AuIONs within the tumor mass and low nonspecific accumulation in the liver and spleen, resulting in high specificity to solid tumors. T(2)-weighted MR images following intravenous injection of PEG-AuIONs showed selective negative enhancement of tumor tissue in an orthotopic pancreatic cancer model prepared with Mia-PaCa-2 human pancreatic adenocarcinoma cells. These results indicate that PEG-AuIONs are a promising MRI contrast agent for diagnosis of malignant tumors, including pancreatic cancer.
- リンク情報
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- DOI
- https://doi.org/10.1002/marc.201000341
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/21567561
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000282078800006&DestApp=WOS_CPL
- URL
- http://www.scopus.com/inward/record.url?eid=2-s2.0-77956314660&partnerID=MN8TOARS
- URL
- http://orcid.org/0000-0003-1593-1855
- ID情報
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- DOI : 10.1002/marc.201000341
- ISSN : 1022-1336
- eISSN : 1521-3927
- ORCIDのPut Code : 38046650
- PubMed ID : 21567561
- SCOPUS ID : 77956314660
- Web of Science ID : WOS:000282078800006