間野祐司 (Mano Yuji) - マイポータル

基本情報

所属: エーザイ（株）グローバル薬物動態研究所
: 筑波大学　連携大学院医学医療系

学位: 博士（薬学）

J-GLOBAL ID: 202101020078466078
Researcher ID: J-5546-2017
researchmap会員ID: R000029702

研究キーワード

研究分野

経歴

2022年4月 - 現在

筑波大学, 医学医療系連携大学院, 准教授
2007年8月 - 現在

エーザイ（株）, グローバル薬物動態研究所, シニアディレクター
- 2007年7月

アステラス製薬（株）, 薬物動態研究所
山之内製薬（株）, 薬物動態研究所

学歴

主要な論文

Development of the Complement C5 Assay by LC-MS/MS in Monkey Serum and Comparison with Enzyme-Linked Immunosorbent Assay.

Kiyomi Kikuchi, Yoko Ida, Tomohiro Yamada, Yuji Mano

ACS omega 9(6) 6797-6802 2024年2月13日査読有り最終著者責任著者
Generic UPLC-MS/MS and Gyrolab assays with blood microsampling for pharmacokinetic assessments of therapeutic antibodies in mice.

Yuji Mano, Kenji Kita, Marina Tsugaru, Koichiro Hotta, Tomoko Kojima, Ken-Ichi Noritake

Journal of pharmaceutical and biomedical analysis 241 115993-115993 2024年1月26日査読有り筆頭著者責任著者
A sensitive assay for the determination of E7090, a novel selective inhibitor of fibroblast growth factor receptors, and its metabolite in human plasma by UPLC-MS/MS with at-column dilution.

Yuji Mano, Ikumi Nitanai, Koichiro Hotta

Journal of pharmaceutical and biomedical analysis 238 115866-115866 2024年1月20日査読有り筆頭著者責任著者
A Simple UPLC-MS/MS Assay of Rifampin in a Small Volume of Human Plasma

Takuya Sano, Takuho Ishii, Koichiro Hotta, Yuji Mano

ACS Omega 8(39) 36261-36268 2023年10月3日査読有り最終著者責任著者
Quantification of anti-drug antibodies against E6011, an anti-fractalkine monoclonal antibody, in monkey and human serum, by an electrochemiluminescence assay.

Muneo Aoyama, Yuji Mano

Journal of pharmacological and toxicological methods 124 107470-107470 2023年9月7日査読有り最終著者責任著者
Cross-species comparison in nonclinical pharmacokinetics of lenvatinib by a simple HPLC with ultraviolet detection.

Hitoshi Mizuo, Yuji Mano

Scientific reports 13(1) 8349-8349 2023年5月23日査読有り最終著者責任著者
A validated UPLC-MS/MS assay of E7090, a novel selective inhibitor of fibroblast growth factor receptors, in human plasma and urine

Yoshiki Asakawa, Takuya Sano, Koichiro Hotta, Yukiko Miyajima, Yuji Mano

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 225 115216-115216 2023年2月査読有り最終著者責任著者
An electrochemiluminescence assay for quantification of Denileukin Diftitox and its anti-drug antibodies in rat serum

Yuji Mano

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS 119(Jan-Feb) 107239-107239 2023年1月査読有り筆頭著者責任著者
A simple UPLC-MS/MS assay with a core-shell column for the determination of exemestane in human plasma for clinical application

Takuho Ishii, Nana Nojiri, Yuji Mano

EUROPEAN JOURNAL OF MASS SPECTROMETRY 28(3-4) 94-103 2022年8月査読有り最終著者責任著者
A separate assay of released and liposomal encapsulated eribulin in dog plasma by liquid chromatography with tandem mass spectrometry for its application to a pharmacokinetic study

Yuji Mano

JOURNAL OF SEPARATION SCIENCE 45 1636-1645 2022年3月査読有り筆頭著者責任著者
Quantitative and qualitative application of a novel capillary microsampling device, Microsampling Wing (TM) (MSW), using antiepileptic drugs in rats

Koichiro Hotta, Tomomi Ishida, Ken-ichi Noritake, Kenji Kita, Yuji Mano

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 194 113788-113788 2021年2月査読有り最終著者責任著者
A sensitive bioanalytical assay for methylcobalamin, an endogenous and light-labile substance, in human plasma by liquid chromatography with tandem mass spectrometry and its application to a pharmacokinetic study

Koichiro Hotta, Yue Wang, Yuji Mano

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 191 113621-113621 2020年11月査読有り最終著者責任著者
Establishment of a simultaneous assay for lemborexant, a novel dual orexin receptor antagonist, and its three metabolites, and its application to a clinical protein binding study

Yuji Mano, Takashi Ueno, Koichiro Hotta

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 187 113359-113359 2020年8月査読有り筆頭著者責任著者
Minimal impact of hepatic and renal impairment on plasma protein binding of lenvatinib, and identification of its major plasma binding protein

Yuji Mano, Hitoshi Mizuo

BIOPHARMACEUTICS & DRUG DISPOSITION 40(8) 307-311 2019年9月査読有り筆頭著者責任著者
Application of a Volumetric Absorptive Microsampling Device to a Pharmacokinetic Study of Tacrolimus in Rats: Comparison with Wet Blood and Plasma

Kenji Kita, Kenichi Noritake, Yuji Mano

EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS 44(1) 91-102 2019年2月査読有り最終著者責任著者
Application of an electrochemiluminescence assay for quantification of E6011, an antifractalkine monoclonal antibody, to pharmacokinetic studies in monkeys and humans

Muneo Aoyama, Yuji Mano

JOURNAL OF CLINICAL LABORATORY ANALYSIS 33(1) e22625 2019年1月査読有り最終著者責任著者
Method validation studies and an inter-laboratory cross validation study of lenvatinib assay in human plasma using LC-MS/MS

Yuji Mano

PRACTICAL LABORATORY MEDICINE 12 e00103 2018年11月査読有り筆頭著者責任著者
LC-MS-MS Determination of Oxcarbazepine and an Active Metabolite in Human Plasma for Clinical Application

Yuji Mano

JOURNAL OF CHROMATOGRAPHIC SCIENCE 56(8) 687-694 2018年9月査読有り筆頭著者責任著者
A dried blood spot assay with UPLC-MS/MS for the simultaneous determination of E6005, a phosphodiesterase 4 inhibitor, and its metabolite in human blood

Kenji Kita, Takuho Ishii, Koichiro Hotta, Yuji Mano

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 157 208-216 2018年8月査読有り最終著者責任著者
Application of volumetric absorptive microsampling device for quantification of tacrolimus in human blood as a model drug of high blood cell partition

Kenji Kita, Yuji Mano

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 143 168-175 2017年9月査読有り最終著者責任著者
An inter-laboratory cross-validation study for the determination of perampanel in human plasma by liquid chromatography assays

Yuji Mano

BIOMEDICAL CHROMATOGRAPHY 30(12) 2067-2069 2016年12月査読有り筆頭著者責任著者
Simultaneous Determination of Donepezil and Its Three Metabolites in Human Plasma Using LC-MS-MS

Yuji Mano, Koichiro Hotta, Kazutomi Kusano

JOURNAL OF CHROMATOGRAPHIC SCIENCE 54(8) 1328-1335 2016年9月査読有り筆頭著者責任著者
HPLC with fluorescence detection assay of perampanel, a novel AMPA receptor antagonist, in human plasma for clinical pharmacokinetic studies

Yuji Mano, Osamu Takenaka, Kazutomi Kusano

BIOMEDICAL CHROMATOGRAPHY 29(10) 1589-1593 2015年10月査読有り筆頭著者責任著者
A validated LC-MS/MS method of total and unbound lenvatinib quantification in human serum for protein binding studies by equilibrium dialysis

Yuji Mano, Kazutomi Kusano

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 114 82-87 2015年10月査読有り筆頭著者責任著者
Validation of a hydrophilic interaction ultra-performance liquid chromatography-tandem mass spectrometry method for the determination of gemcitabine in human plasma with tetrahydrouridine

Yuji Mano, Kenji Sakamaki, Takuya Ueno, Kenji Kita, Takuho Ishii, Koichiro Hotta, Kazutomi Kusano

BIOMEDICAL CHROMATOGRAPHY 29(9) 1343-1349 2015年9月査読有り筆頭著者責任著者
Validation of an ultra-performance liquid chromatography-tandem mass spectrometry method for the determination of flecainide in human plasma and its clinical application

Yuji Mano, Yoshiki Asakawa, Kenji Kita, Takuho Ishii, Koichiro Hotta, Kazutomi Kusano

BIOMEDICAL CHROMATOGRAPHY 29(9) 1399-1405 2015年9月査読有り筆頭著者責任著者
Validation of a UPLC-MS/MS method for the simultaneous determination of E6005, a phosphodiesterase 4 inhibitor, and its metabolite in human plasma

Yuji Mano, Takuho Ishii, Koichiro Hotta, Kazutomi Kusano

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 998 31-39 2015年8月査読有り筆頭著者責任著者
High-performance liquid chromatography-tandem mass spectrometry method for the determination of perampanel, a novel alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist in human plasma

Yuji Mano, Osamu Takenaka, Kazutomi Kusano

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 107 56-62 2015年3月査読有り筆頭著者責任著者
Hematocrit-independent recovery is a key for bioanalysis using volumetric absorptive microsampling devices, Mitra(TM)

Yuji Mano, Kenji Kita, Kazutomi Kusano

BIOANALYSIS 7(15) 1821-1829 2015年査読有り筆頭著者責任著者
Species differences in inhibition potential of nonsteroidal anti-inflammatory drugs against estradiol 3 beta-glucuronidation between rats, dogs, and humans

Yuji Mano, Takashi Usui, Hidetaka Kamimura

JOURNAL OF PHARMACEUTICAL SCIENCES 97(7) 2805-2810 2008年7月査読有り筆頭著者責任著者
The UDP-glucuronosyltransferase 2B7 isozyme is responsible for gemfibrozil glucuronidation in the human liver

Yuji Mano, Takashi Usui, Hidetaka Kamimura

DRUG METABOLISM AND DISPOSITION 35(11) 2040-2044 2007年11月査読有り筆頭著者責任著者
Substrate-dependent modulation of UDP-Glucuronosyltransferase 1A1 (UGT1A1) by propofol in recombinant human UGT1A1 and human liver Microsomes

Yuji Mano, Takashi Usui, Hidetaka Kamimura

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY 101(3) 211-214 2007年9月査読有り筆頭著者責任著者
Predominant contribution of UDP-glucuronosyltransferase 2B7 in the glucuronidation of racemic flurbiprofen in the human liver

Yuji Mano, Takashi Usui, Hidetaka Kamimura

DRUG METABOLISM AND DISPOSITION 35(7) 1182-1187 2007年7月査読有り筆頭著者責任著者
Comparison of inhibition potentials of drugs against zidovudine glucuronidation in rat hepatocytes and liver microsomes

Yuji Mano, Takashi Usui, Hidetaka Kamimura

DRUG METABOLISM AND DISPOSITION 35(4) 602-606 2007年4月査読有り筆頭著者責任著者
Contribution of UDP-glucuronosyltransferases 1A9 and 2B7 to the glucuronidation of indomethacin in the human liver

Yuji Mano, Takashi Usui, Hidetaka Kamimura

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 63(3) 289-296 2007年3月査読有り筆頭著者責任著者
Inhibitory potential of nonsteroidal anti-inflammatory drugs on UDP-glucuronosyltransferase 2B7 in human liver microsomes

Yuji Mano, Takashi Usui, Hidetaka Kamimura

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 63(2) 211-216 2007年2月査読有り筆頭著者責任著者
Effects of bosentan, an endothelin receptor antagonist, on bile salt export pump and multidrug resistance-associated protein 2

Yuji Mano, Takashi Usui, Hidetaka Kamimura

BIOPHARMACEUTICS & DRUG DISPOSITION 28(1) 13-18 2007年1月査読有り筆頭著者責任著者
In vitro drug interaction between diflunisal and indomethacin via glucuronidation in humans

Yuji Mano, Takashi Usui, Hidetaka Kamimura

BIOPHARMACEUTICS & DRUG DISPOSITION 27(6) 267-273 2006年9月査読有り筆頭著者責任著者
Identification of human UDP-glucuronosyltransferase responsible for the glucuronidation of niflumic acid in human liver

Yuji Mano, Takashi Usui, Hidetaka Kamimura

PHARMACEUTICAL RESEARCH 23(7) 1502-1508 2006年7月査読有り筆頭著者責任著者
Hepatobiliary transport of YM466, a novel factor Xa inhibitor, in rats

Yuji Mano, Takashi Usui, Hidetaka Kamimura

EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS 31(2) 117-121 2006年4月査読有り筆頭著者責任著者
In vitro inhibitory effects of non-steroidal anti-inflammatory drugs on 4-methylumbelliferone glucuronidation in recombinant human UDP-glucuronosyltransferase 1A9--potent inhibition by niflumic acid.

Yuji Mano, Takashi Usui, Hidetaka Kamimura

Biopharmaceutics & drug disposition 27(1) 1-6 2006年1月査読有り筆頭著者責任著者
In vitro inhibitory effects of non-steroidal antiinflammatory drugs on UDP-glucuronosyltransferase 1A1-catalysed estradiol 3beta-glucuronidation in human liver microsomes.

Yuji Mano, Takashi Usui, Hidetaka Kamimura

Biopharmaceutics & drug disposition 26(1) 35-9 2005年1月査読有り筆頭著者責任著者
Effects of beta-estradiol and propofol on the 4-methylumbelliferone glucuronidation in recombinant human UGT isozymes 1A1, 1A8 and 1A9.

Yuji Mano, Takashi Usui, Hidetaka Kamimura

Biopharmaceutics & drug disposition 25(8) 339-44 2004年11月査読有り筆頭著者責任著者
A liquid chromatographic-tandem mass spectrometric method for the determination of YM466, a novel Factor Xa inhibitor, in rat plasma.

Yuji Mano, Takashi Usui, Hidetaka Kamimura

Journal of pharmaceutical and biomedical analysis 36(4) 883-7 2004年11月査読有り筆頭著者責任著者
Absorption, distribution, metabolism and excretion of YM466, a novel factor Xa inhibitor, in rats.

Yuji Mano, Takuya Sonoda, Eiji Nakamura, Takashi Usui, Hidetaka Kamimura

Biopharmaceutics & drug disposition 25(6) 253-60 2004年9月査読有り筆頭著者責任著者
Pharmacokinetics of YM466, a new factor Xa inhibitor, in rats and dogs.

Yuji Mano

Eur J Drug Metab Pharmacokinet. 2004 Jan-Mar;29(1):7-13. 29(1) 7-13 2004年1月査読有り筆頭著者責任著者
Investigation of the high partition of YM992, a novel antidepressant, in rat brain - in vitro and in vivo evidence for the high binding in brain and the high permeability at the BBB.

Yuji Mano, Saburo Higuchi, Hidetaka Kamimura

Biopharmaceutics & drug disposition 23(9) 351-60 2002年12月査読有り筆頭著者責任著者
LC determination of YM466, a new factor Xa inhibitor, in rat and dog plasma.

Yuji Mano, Toshiko Aoki, Yumiko Kikuchi, Yoshiaki Soeishi, Takashi Usui, Hidetaka Kamimura

Journal of pharmaceutical and biomedical analysis 29(4) 631-8 2002年7月査読有り筆頭著者責任著者
Kinetic analysis of the disposition of MRK16, an anti-P-glycoprotein monoclonal antibody, in tumors: Comparison between in vitro and in vivo disposition

Mano, Y., Suzuki, H., Terasaki, T., Iwahashi, T., Ono, K.-I., Naito, M., Tsuruo, T., Sugiyama, Y.

Journal of Pharmacology and Experimental Therapeutics 283(1) 391-394 1997年10月査読有り筆頭著者

もっとみる

主要なMISC

実験方法シリーズ:グルクロン酸抱合代謝の実験方法

間野祐司

Drug Metabolism and Pharmacokinetics 24(3) 2-9 2009年6月招待有り筆頭著者
薬剤学,製剤学,病院薬学 Caco-2細胞系はヒトにおける薬物吸収を予測可能か?

間野祐司

ファルマシア 34(4) 367-368 1998年4月招待有り筆頭著者

もっとみる

主要な講演・口頭発表等

Quantification of rifampicin in a small volume of human plasma by UPLC-MS/MS with addressing the carryover issue

Yuji Mano

IATDMCT 2023 (Oslo, Norway) 2023年9月25日
A SEPARATE DETERMINATION OF RELEASED AND LIPOSOMAL ENCAPSULATED ERIBULIN IN DOG PLASMA BY LC-MS/MS FOR ITS APPLICATION TO A PHARMACOKINETIC STUDY

Yuji Mano

31th International Symposium on Pharmaceutical and Biomedical Analysis (Kyoto, Japan) 2021年9月
DEVELOPMENT AND VALIDATION OF A HIGHLY SENSITIVE ASSAY METHOD FOR THE DETERMINATION OF LEMBOREXANT, A NOVEL DUAL RECEPTOR ANTAGONIST, AND ITS THREE METABOLITES, FOR ITS APPLICATION TO AN EX VIVO PLASMA PROTEIN BINDING STUDY

Yuji Mano

13th Workshop on recent issues in bioanalysis (New Orleans, LA) 2019年4月
APPLICATION OF VOLUMETRIC ABSORPTIVE MICROSAMPLING TO A PHARMACOKINETIC STUDY OF TACROLIMUS IN RATS

Yuji Mano

12th Workshop on recent issue in bioanalysis (Philadelphia, PA) 2018年4月
VALIDATION OF HYDROPHILIC INTERACTION ULTRA-PERFORMANCE LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY METHOD FOR THE DETERMINATION OF GEMCITABINE IN HUMAN PLASMA WITH TETRAHYDROURIDINE

Yuji Mano

9th Workshop on recent issue in bioanalysis (Miami, FL) 2015年4月
グルクロン酸抱合代謝とその実験法

間野祐司

第18回薬物動態談話会セミナー（東京） 2014年8月招待有り
ヒト肝ミクロソームを用いたUGT2B7 に対する非ステロイド性抗炎症薬の阻害評価

間野祐司

日本薬物動態学会21年会（東京） 2006年11月
IDENTIFICATION OF THE HUMAN UDP-GLUCRONOSYLTRANSFERASE RESPONSIBLE FOR THE GLUCURONIZATION OF NIFLUMIC ACID IN THE LIVER

Yuji Mano

14th North American ISSX (Rio Grande, PR) 2006年10月
INVESTIGATION OF THE HIGH PARTITION OF YM992, A NOVEL ANTIDEPRESSANT, IN RAT BRAIN - iN VITRO AND IN VIVO EVIDENCE FOR THE HIGH BINDING IN BRAIN AND THE HIGH PERMEABILITY AT THE BBB.

Yuji Mano

6th International ISSX (Munich, Germany) 2001年11月

もっとみる