2021年12月
Dietary cis-9, trans-11-conjugated linoleic acid reduces amyloid β-protein accumulation and upregulates anti-inflammatory cytokines in an Alzheimer’s disease mouse model
Scientific Reports
- 巻
- 11
- 号
- 1
- 開始ページ
- 9749
- 終了ページ
- 9749
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/s41598-021-88870-9
Conjugated linoleic acid (CLA) is an isomer of linoleic acid (LA). The predominant dietary CLA is cis-9, trans-11-CLA (c-9, t-11-CLA), which constitutes up to ~ 90% of total CLA and is thought to be responsible for the positive health benefits associated with CLA. However, the effects of c-9, t-11-CLA on Alzheimer’s disease (AD) remain to be elucidated. In this study, we investigated the effect of dietary intake of c-9, t-11-CLA on the pathogenesis of an AD mouse model. We found that c-9, t-11-CLA diet-fed AD model mice significantly exhibited (1) a decrease in amyloid-β protein (Aβ) levels in the hippocampus, (2) an increase in the number of microglia, and (3) an increase in the number of astrocytes expressing the anti-inflammatory cytokines, interleukin-10 and 19 (IL-10, IL-19), with no change in the total number of astrocytes. In addition, liquid chromatography–tandem mass spectrometry (LC–MS/MS) and gas chromatographic analysis revealed that the levels of lysophosphatidylcholine (LPC) containing c-9, t-11-CLA (CLA-LPC) and free c-9, t-11-CLA were significantly increased in the brain of c-9, t-11-CLA diet-fed mice. Thus, dietary c-9, t-11-CLA entered the brain and appeared to exhibit beneficial effects on AD, including a decrease in Aβ levels and suppression of inflammation.
- リンク情報
-
- DOI
- https://doi.org/10.1038/s41598-021-88870-9
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/33980877
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8115273
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85105825045&origin=inward 本文へのリンクあり
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85105825045&origin=inward
- ID情報
-
- DOI : 10.1038/s41598-021-88870-9
- eISSN : 2045-2322
- PubMed ID : 33980877
- PubMed Central 記事ID : PMC8115273
- SCOPUS ID : 85105825045