2012年9月
Systems biology approaches to toll-like receptor signaling
WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE
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- 巻
- 4
- 号
- 5
- 開始ページ
- 497
- 終了ページ
- 507
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/wsbm.1178
- 出版者・発行元
- WILEY
Toll-like receptor (TLR) signaling pathways constitute an evolutionarily conserved host defense system that protects against a broad range of infectious agents. Modeling of TLR signaling has been carried out at several levels. Structural models of TLRs and their adaptors, which utilize a small number of structural domains to recognize a diverse range of pathogens, provide a starting point for understanding how pathogens are recognized and signaling events initiated. Various experimental and computational techniques have been used to construct models of downstream signal transduction networks from the measurements of gene expression and chromatin structure under resting and perturbed conditions along with predicted regulatory sequence motifs. Although a complete and accurate mathematical model of all TLR signaling pathways has yet to be derived, many important modules have been identified and investigated, enhancing our understanding of innate immune responses. Extensions of these models based on emerging experimental techniques are discussed. WIREs Syst Biol Med 2012 doi: 10.1002/wsbm.1178 For further resources related to this article, please visit the WIREs website.
- リンク情報
- ID情報
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- DOI : 10.1002/wsbm.1178
- ISSN : 1939-5094
- eISSN : 1939-005X
- PubMed ID : 22714995
- Web of Science ID : WOS:000307731200006