HIRAYAMA TASUKU

Profile Information

Affiliation: Faculty of Pharmaceutical Science, Gifu Pharmaceutical University

Degree: 博士(人間・環境学)(京都大学)

J-GLOBAL ID: 201801009247978572
researchmap Member ID: B000347145

External link: https://yakka-gifu-pu.jp/

Research Interests

Research Areas

Research History

Apr, 2016 - Present

Associate Professor, Laboratory of Pharmaceutical & Medicinal Chemistry, Gifu Pharmaceutical University
Oct, 2010 - Mar, 2016

Assistant Professor, Laboratory of Pharmaceutical & Medicinal Chemistry, Gifu Pharmaceutical University
Apr, 2009 - Sep, 2010

Postdoctoral fellow, Department of Chemistry, University of California, Berkeley

Education

Apr, 2006 - Mar, 2009

Doctor course, Graduate School of Human and Environmental Studies, Kyoto University
Apr, 2004 - Mar, 2006

Master course, Graduate School of Human and Environmental Studies, Kyoto University
Apr, 2000 - Mar, 2004

Faculty of Integrated Human Science, Kyoto University

Awards

Sep, 2017

Lecture award, CSJ Bio-relevant chemistry division

HIRAYAMA TASUKU
2017

学術奨励賞, 二価鉄イオン選択的蛍光スイッチとしてのN-オキシド化学の確立と細胞内鉄イオンレドックス平衡の解析, 日本酸化ストレス学会

平山祐
2014

学術奨励賞, 細胞内における鉄(II)イオンを可視化する蛍光プローブ分子の開発, 日本鉄バイオサイエンス学会

平山祐
Jun, 2013

Poster Award

HIRAYAMA TASUKU
2013

CSJ Presentation Award 2013, Chemical Society of Japan

HIRAYAMA TASUKU
2009

Japan San Francisco Bay Area seminar poser award, Japan San Francisco Bay Area Researchers' association

HIRAYAMA TASUKU

Papers

Both hemoglobin and hemin cause damage to retinal pigment epithelium through the iron ion accumulation

Aomi Muramatsu, Shinsuke Nakamura, Tasuku Hirayama, Hideko Nagasawa, Akihiro Ohira, Takashi Kitaoka, Hideaki Hara, Masamitsu Shimazawa

Journal of Pharmacological Sciences, 155(2) 44-51, Jun, 2024
Both hemoglobin and hemin cause damage to retinal pigment epithelium through the iron ion accumulation

Aomi Muramatsu, Shinsuke Nakamura, Tasuku Hirayama, Hideko Nagasawa, Akihiro Ohira, Takashi Kitaoka, Hideaki Hara, Masamitsu Shimazawa

Journal of Pharmacological Sciences, 155(2) 44-51, Jun, 2024
Association of poly(rC)-binding protein-2 with sideroflexin-3 through TOM20 as an iron entry pathway to mitochondria.

Danyang Mi, Izumi Yanatori, Hao Zheng, Yingyi Kong, Tasuku Hirayama, Shinya Toyokuni

Free radical research, 1-40, Apr 10, 2024
Elucidation of the stereocontrol mechanisms of the chemical and biosynthetic intramolecular Diels-Alder cycloaddition for the formation of bioactive decalins.

Takumi Kariya, Hayato Hasegawa, Taro Udagawa, Yusaku Inada, Kyoko Nishiyama, Mieko Tsuji, Tasuku Hirayama, Tatsuo Suzutani, Naoki Kato, Shingo Nagano …

RSC advances, 13(40) 27828-27838, Sep 18, 2023
Synthesis and photochemical properties of caged peroxides for photocontrol of cellular oxidative stress

Mieko Tsuji, Haruno Taira, Taro Udagawa, Tatsuya Aoki, Tasuku Hirayama, Hideko Nagasawa

Chemical Communications, 2023
Iron accelerates Fusobacterium nucleatum-induced CCL8 expression in macrophages and is associated with colorectal cancer progression

Taishi Yamane, Yohei Kanamori, Hiroshi Sawayama, Hiromu Yano, Akihiro Nita, Yudai Ohta, Hironori Hinokuma, Ayato Maeda, Akiko Iwai, Takashi Matsumoto …

JCI Insight, Sep 22, 2022
Haloperidol Prevents Oxytosis/Ferroptosis by Targeting Lysosomal Ferrous Ions in a Manner Independent of Dopamine D2 and Sigma-1 Receptors.

Yoko Hirata, Kohei Oka, Shotaro Yamamoto, Hiroki Watanabe, Kentaro Oh-Hashi, Tasuku Hirayama, Hideko Nagasawa, Hiroshi Takemori, Kyoji Furuta

ACS chemical neuroscience, Sep 1, 2022
Molecular Imaging of Labile Heme in Living Cells Using a Small Molecule Fluorescent Probe

Kanta Kawai, Tasuku Hirayama, Haruka Imai, Takanori Murakami, Masatoshi Inden, Isao Hozumi, Hideko Nagasawa

Journal of the American Chemical Society, Feb 8, 2022
Intracellular ferritin heavy chain plays the key role in artesunate-induced ferroptosis in ovarian serous carcinoma cells

Tiger Koike, Motoki Takenaka, Noriko Suzuki, Yoko Ueda, Minako Mori, Tasuku Hirayama, Hideko Nagasawa, Ken-ichirou Morishige

Journal of Clinical Biochemistry and Nutrition, 71(1) 34-40, 2022
Role of ferroptosis in cisplatin-induced acute nephrotoxicity in mice.

Yasumasa Ikeda, Hirofumi Hamano, Yuya Horinouchi, Licht Miyamoto, Tasuku Hirayama, Hideko Nagasawa, Toshiaki Tamaki, Koichiro Tsuchiya

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 67 126798-126798, Sep, 2021
Development of antitumor biguanides targeting energy metabolism and stress responses in the tumor microenvironment.

Takayuki Sakai, Yoshiyuki Matsuo, Kensuke Okuda, Kiichi Hirota, Mieko Tsuji, Tasuku Hirayama, Hideko Nagasawa

Scientific reports, 11(1) 4852-4852, Mar 1, 2021
Asymmetric bismuth-rhodamines as an activatable fluorogenic photosensitizer

Akari Mukaimine, Tasuku Hirayama, Hideko Nagasawa

Organic & Biomolecular Chemistry, 19(16) 3611-3619, 2021 Peer-reviewedCorresponding author
A pH-Adjustable Tissue Clearing Solution That Preserves Lipid Ultrastructures: Suitable Tissue Clearing Method for DDS Evaluation.

Shintaro Fumoto, Eriko Kinoshita, Keisuke Ohta, Kei-Ichiro Nakamura, Tasuku Hirayama, Hideko Nagasawa, Die Hu, Kazuya Okami, Riku Kato, Shojiro Shimokawa …

Pharmaceutics, 12(11), Nov 9, 2020 Peer-reviewed
High-Throughput Screening for the Discovery of Iron Homeostasis Modulators Using an Extremely Sensitive Fluorescent Probe.

Tasuku Hirayama, Masato Niwa, Shusaku Hirosawa, Hideko Nagasawa

ACS sensors, 5(9) 2950-2958, Sep 25, 2020 Peer-reviewedLead authorCorresponding author
Asbestos conceives Fe(II)-dependent mutagenic stromal milieu through ceaseless macrophage ferroptosis and β-catenin induction in mesothelium.

Fumiya Ito, Izumi Yanatori, Yuki Maeda, Kenta Nimura, Satoki Ito, Tasuku Hirayama, Hideko Nagasawa, Norihiko Kohyama, Yasumasa Okazaki, Shinya Akatsuka …

Redox biology, 36 101616-101616, Sep, 2020
Design, Synthesis, and Conformation-Activity Study of Unnatural Bridged Bicyclic Depsipeptides as Highly Potent Hypoxia Inducible Factor-1 Inhibitors and Antitumor Agents.

Kota Koike, Masanobu Nagano, Masahiro Ebihara, Tasuku Hirayama, Mieko Tsuji, Hiroaki Suga, Hideko Nagasawa

Journal of medicinal chemistry, Mar 23, 2020 Peer-reviewed
A 19F-MRI probe for the detection of Fe(ii) ions in an aqueous system

Ryo Kakiuchi, Tasuku Hirayama, Daijiro Yanagisawa, Ikuo Tooyama, Hideko Nagasawa

Organic & Biomolecular Chemistry, 18(30) 5843-5849, 2020 Peer-reviewedCorresponding author
Zinc excess increases cellular demand for iron and decreases tolerance to copper in Escherichia coli.

Zeling Xu, Pengchao Wang, Haibo Wang, Zuo Hang Yu, Ho Yu Au-Yeung, Tasuku Hirayama, Hongzhe Sun, Aixin Yan

The Journal of biological chemistry, 294(45) 16978-16991, Nov 8, 2019 Peer-reviewed
悪性腫瘍細胞に対するArtemisinin誘導体の鉄依存性抗腫瘍効果(Iron-dependent antitumor effect of artemisinin derivatives on malignant cells)

上田陽子, 鈴木紀子, 平山祐, 永澤秀子, 森重健一郎

日本癌学会総会記事, 78回 P-3348, Sep, 2019
Carbonic anhydrase 9 confers resistance to ferroptosis/apoptosis in malignant mesothelioma under hypoxia.

Zan Li, Li Jiang, Shan Hwu Chew, Tasuku Hirayama, Yoshitaka Sekido, Shinya Toyokuni

Redox biology, 26 101297-101297, Sep, 2019 Peer-reviewed

Misc.

Development of Fe(II)-detective ¹⁹F-MRI probe utilizing chemical shift-switch

垣内亮, 平山祐, 柳沢大治郎, 遠山育夫, 辻美恵子, 永澤秀子

日本薬学会年会要旨集(Web), 141st, 2021
Development of new boron carriers for BNCT targeting amino acid transporters

松下明香里, 辻美恵子, 真田悠生, 平山祐, 増永慎一郎, 永澤秀子

KURNS-EKR (Web), (10), 2021
がん微小環境モジュレーターの創出をめざす創薬研究

永澤秀子, 境崇行, 小池晃太, 奥田健介, 平山祐, 辻美恵子

日本薬学会年会要旨集(CD-ROM), 139th, 2019
生体内の鉄(II)イオン検出を指向した¹⁹F-MRIプローブ分子の開発

鈴木萌恵, 平山祐, 柳沢大治郎, 遠山育夫, 永澤秀子

日本薬学会年会要旨集(CD-ROM), 138th, 2018
脳出血病態におけるheminの二価鉄蓄積を介した障害に関する検討

今井貴彦, 中村信介, 岩田星菜, 平山祐, 永澤秀子, 嶋澤雅光, 原英彰

脳循環代謝(Web), 30(1), 2018
がん微小環境標的ビグアニド誘導体の創薬研究

境崇行, 小池晃太, 三木彩路, 横尾沙季, 平山祐, 奥田健介, 永澤秀子

日本薬学会年会要旨集(CD-ROM), 137th, 2017
がん微小環境のエネルギー代謝を標的とするがん治療薬の開発

境崇行, 平山祐, 辻美恵子, 永澤秀子

日本がん分子標的治療学会学術集会プログラム・抄録集, 21st, 2017
がん微小環境における低栄養ストレス応答を標的とするビグアニド誘導体の創薬研究

境崇行, 辻美恵子, 平山祐, 奥田健介, 永澤秀子

メディシナルケミストリーシンポジウム講演要旨集, 35th, 2017
Blood-Brain Barrierに対するHemoglobin関連分子の影響

今井貴彦, 岩田星菜, 平山祐, 永澤秀子, 嶋澤雅光, 原英彰

脳循環代謝(Web), 29(1), 2017
NOVEL FLUORESCENT PROBE DETECTING CATALYTIC FERROUS IRON

Ohara, Tasuku Hirayama, Hideko Nagasawa

AMERICAN JOURNAL OF HEMATOLOGY, 91(3) E217-E217, Mar, 2016
生体組織内での鉄(II)イオン検出を目指した¹⁹F-MRIプローブ分子の開発

鈴木萌恵, 平山祐, 柳沢大治郎, 遠山育夫, 永澤秀子

日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会講演要旨集, 26th-2016, 2016
Iron chelation restores mitophagy suppressed by hepatitis C virus

Yuichi Hara, Sohji Nishina, Tasuku Hirayama, Hideko Nagasawa, Keisuke Hino

HEPATOLOGY, 62 696A-697A, Oct, 2015
ビグアニド系がん微小環境モジュレーターの標的分子解明を目指すアフィニティプローブの開発

境崇行, 奥田健介, 竹本安那, 平山祐, 永澤秀子

日本薬学会年会要旨集(CD-ROM), 135th, 2015
The development study of hypoxia responsive chemiluminescent probe for tumor hypoxia imaging

Kensuke Okuda, Toru Ban, Tasuku Hirayama, Hideko Nagasawa

CANCER RESEARCH, 74(19), Oct, 2014
Development of fluorescent probes for labile Fe(II) ion in oxidative stress

Tasuku Hirayama, Masato Niwa, Satoki Kadota, Tomoyo Imamura, Kensuke Okuda, Hideaki Hara, Hideko Nagasawa

JOURNAL OF PHARMACOLOGICAL SCIENCES, 124 49P-49P, 2014
FRET-based imaging of transbilayer movement of pepducin in living cells by novel intracellular bioreductively activatable fluorescent probes (vol 11, pg 3030, 2013)

Mieko Tsuji, Satoshi Ueda, Tasuku Hirayama, Kensuke Okuda, Yoshiaki Sakaguchi, Aoi Isono, Hideko Nagasawa

ORGANIC & BIOMOLECULAR CHEMISTRY, 11(48) 8510-8510, Dec, 2013
がんの in vivo イメージングを目指す低酸素応答性PET型近赤外蛍光プローブの論理的分子設計と合成

河野樹, 奥田健介, 平山祐, 宇野文二, 永澤秀子

バイオイメージング, 20(2) 179-180, Aug 10, 2011
Tasuku Hirayama, Masayasu Taki, and Yukio Yamamoto

Tasuku Hirayama, Masayasu Taki, Yukio Yamamoto

山本行男（教授）【学会発表】 14th International Conference on Biological Inorganic Chemistry (ICBIC XIV), Nagoya, Japan, July, 2009, 2009 Peer-reviewed
Artificial Peptide Tag Recognition by Dinuclear Zinc Complex and Luminescence Switching with Lanthanide Complex

Tasuku Hirayama, Masayasu Taki, Yukio Yamamoto

The 4th Asian Biological Inorganic Chemistry Conference (AsBIC IV), Jeju, Korea, Nov, 2008

Teaching Experience

Professional Memberships

Research Projects

Chemical-tool-driven research on heme dynamics

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2026
Development and application of practical ferromics technology

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2024
Development of novel boron carrier utilizing amino acid transporters specific for glutamine addiction of cancer cells

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2023
Development of fundamental technology for electron microscopic imaging of short-lived chemical species

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory), Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jul, 2020 - Mar, 2022

Hirayama Tasuku
Development of ferromics probes for molecular and spacial analysis

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2022
Elucidation and control of iron homeostasis based on iron-sensing technology using N-oxide chemistry

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

Hirayama Tasuku
細胞骨格を足場とする酸化ストレスナノイメージング法の開発

科学研究費助成事業新学術領域研究(研究領域提案型), 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2018 - Mar, 2020

平山祐
Basic study for chemical biology of heme

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory), Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2017 - Mar, 2019

Hirayama Tasuku
Development of tumor-selective drug based on synthetic lethal strategy by overcoming oxidative stress tolerance of cancer

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

Nagasawa Hideko
超解像からin vivoイメージングまで使える酸化ストレス分子マッピング法の開発

科学研究費助成事業新学術領域研究(研究領域提案型), 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2016 - Mar, 2018

平山祐
Development of novel organobismuth molecules as photosensitizers for theranostics of tumor

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2017

Hirayama Tasuku, KONDO Shinae
Development of versatile N-oxide-based fluorescent probes to study pathological dysfunction of iron metabolism

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (A), Grant-in-Aid for Young Scientists (A), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2017

Hirayama Tasuku, NIWA Masato, TSUBOI Hitomi, KADOTA Satoki, IKESHITA Yukie, MIKI Ayaji, KATABE Tomoyo
The study of drug development targeting the stress response in the tumor microenvironment for the treatment of refractory cancer

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015

HIDEKO Nagasawa, OKUDA Kensike, HIRAYAMA Tasuku, MORISHIGE Kenichiro
Coordination chemistry to clinical applications-development of MRI probes based on redox chemistry of metal complexes

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2011 - 2012

HIRAYAMA Tasuku
ペプチド型希土類錯体を用いたタンパク質結合性多機能亜鉛蛍光プローブの開発

科学研究費助成事業特別研究員奨励費, 特別研究員奨励費, 日本学術振興会, 2010 - 2010

平山祐
蛍光性希土類錯体を用いた新しいタンパク質認識システムの開発

科学研究費助成事業特別研究員奨励費, 特別研究員奨励費, 日本学術振興会, 2008 - 2009

平山祐

Industrial Property Rights

特開2019-147776 蛍光プローブ

永澤秀子, 平山祐, 丹羽正人
特許第5991831号蛍光プローブ

永澤秀子, 平山祐
WO2015-108172 鉄(II)イオン検出剤及びそれを用いた検出方法

永澤秀子, 平山祐
特開2013-193990 蛍光プローブ

永澤秀子, 平山祐

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Research Interests

Research Areas

Research History

Education

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Papers

Misc.

Teaching Experience

Professional Memberships

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Industrial Property Rights

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