茶山弘美 (Hiromi Abe-Chayama) - マイポータル

基本情報

所属: 広島大学大学院医系科学研究科（医）准教授

学位: 博士（医学）(広島大学)

J-GLOBAL ID: 201801020797918465
researchmap会員ID: B000323703

研究分野

ライフサイエンス / 感染症内科学 /

受賞

2014年10月

Bristol-Myers Award, 日本消化器病学会

茶山弘美
2009年6月

海外研修スポンサーシップ2009, 日本肝臓学会

茶山弘美

論文

140

HBV with precore and basal core promoter mutations exhibits a high replication phenotype and causes ER stress-mediated cell death in humanized liver chimeric mice.

Takuro Uchida, Michio Imamura, C Nelson Hayes, Yosuke Suehiro, Yuji Teraoka, Kazuki Ohya, Hiroshi Aikata, Hiromi Abe-Chayama, Yuji Ishida, Chise Tateno …

Hepatology (Baltimore, Md.) 2023年3月13日
A novel cDNA-uPA/SCID/Rag2-/- /Jak3-/- mouse model for hepatitis virus infection and reconstruction of human immune system.

Takuro Uchida, Yuji Teraoka, Michio Imamura, Hiromi Abe-Chayama, Grace Naswa Makokha, Clair Nelson Hayes, Hiroshi Aikata, Satoko Hamamura, Yuji Ishida, Chise Tateno …

Journal of viral hepatitis 30(3) 262-272 2022年12月27日
HBV upregulates TRAIL-R3 expression in hepatocytes for escaping both cell apoptosis and suppression of their replication by TRAIL.

Yosuke Suehiro, Masataka Tsuge, Mio Kurihara, Takuro Uchida, Hatsue Fujino, Atsushi Ono, Masami Yamauchi, Grace Naswa Makokha, Takashi Nakahara, Eisuke Murakami …

The Journal of infectious diseases 2022年2月28日
Untying relaxed circular DNA of hepatitis B virus by polymerase reaction provides a new option for accurate quantification and visualization of covalently closed circular DNA.

Naohiro Kamiya, Takahiko Sugimoto, Hiromi Abe-Chayama, Rie Akiyama, Yasunori Tsuboi, Akira Mogami, Michio Imamura, C Nelson Hayes, Kazuaki Chayama

The Journal of general virology 103(2) 2022年2月
Construction of an anti-hepatitis B virus preS1 antibody and usefulness of preS1 measurement for chronic hepatitis B patients: Anti-HBV PreS1 antibody.

Haruna Hatooka, Yumi Shimomura, Michio Imamura, Yuji Teraoka, Kei Morio, Hatsue Fujino, Atsushi Ono, Takashi Nakahara, Eisuke Murakami, Masami Yamauchi …

The Journal of infection 2021年12月23日
Serum PreS1 and HBsAg ratio reflects liver fibrosis and predicts the development of hepatocellular carcinoma in chronic hepatitis B patients.

Yuno Nishida, Michio Imamura, Yuji Teraoka, Kei Morio, Hatsue Fujino, Atsushi Ono, Takashi Nakahara, Eisuke Murakami, Masami Yamauchi, Tomokazu Kawaoka …

Journal of viral hepatitis 28(9) 1304-1311 2021年9月
Novel drug resistance-associated substitutions against pibrentasvir emerged in genotype 1b hepatitis C virus-infected human hepatocyte transplanted mice.

Kazuki Ohya, Michio Imamura, Yuji Teraoka, Takuro Uchida, Hatsue Fujino, Takashi Nakahara, Atsushi Ono, Eisuke Murakami, Masami Yamauchi, Tomokazu Kawaoka …

Biochemical and biophysical research communications 559 78-83 2021年6月25日
Abatacept treatment for patients with severe acute hepatitis caused by hepatitis B virus infection-Pilot study

Yuji Teraoka, Michio Imamura, Takuro Uchida, Kazuki Ohya, Kei Morio, Hatsue Fujino, Atsushi Ono, Takashi Nakahara, Eisuke Murakami, Masami Yamauchi …

JOURNAL OF VIRAL HEPATITIS 28(2) 400-409 2021年2月
In vitro analysis of hepatic stellate cell activation influenced by transmembrane 6 superfamily 2 polymorphism

Songyao Liu, Eisuke Murakami, Takashi Nakahara, Kazuki Ohya, Yuji Teraoka, Grace Naswa Makokha, Takuro Uchida, Kei Morio, Hatsue Fujino, Atsushi Ono …

MOLECULAR MEDICINE REPORTS 23(1) 2021年1月
Signal Activation of Hepatitis B Virus-Related Hepatocarcinogenesis by Up-regulation of SUV39h1

Yasue Takeuchi, Masataka Tsuge, Ken Tsushima, Yosuke Suehiro, Hatsue Fujino, Atsushi Ono, Masami Yamauchi, Grace Naswa Makokha, Takashi Nakahara, Eisuke Murakami …

JOURNAL OF INFECTIOUS DISEASES 222(12) 2061-2070 2020年12月
核酸アナログ内服中のB型慢性肝炎患者における肝線維化および発癌予測マーカーとしての血清オートタキシン濃度の有効性

藤野初江, 寺岡雄吏, 盛生慶, 大野敦司, 中原隆志, 村上英介, 河岡友和, 三木大樹, 柘植雅貴, 平松憲 …

日本消化器病学会雑誌 117(臨増総会) A338-A338 2020年7月
Circulating cytokines and angiogenic factors based signature associated with the relative dose intensity during treatment in patients with advanced hepatocellular carcinoma receiving lenvatinib

Atsushi Ono, Hiroshi Aikata, Masami Yamauchi, Kenichiro Kodama, Waka Ohishi, Takeshi Kishi, Kazuki Ohya, Yuji Teraoka, Mitsutaka Osawa, Hatsue Fujino …

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY 12 2020年5月
Targeting clinical epigenetic reprogramming for chemoprevention of metabolic and viral hepatocellular carcinoma

Frank Jühling, Hamdane N, Crouchet E, Li S, El Saghire H, Mukherji A, Fujiwara N, Oudot MA, Thumann C, Saviano A …

Gut 2020年3月査読有り
yRibavirin induces hepatitis C virus genome mutations in chronic hepatitis patients who failed to respond to prior daclatasvir plus asunaprevir therapy

Yuhei Saito, Michio Imamura, Takuro Uchida, Mitsutaka Osawa, Yuji Teraoka, Hatsue Fujino, Takashi Nakahara, Atsushi Ono, Eisuke Murakami, Tomokazu Kawaoka …

JOURNAL OF MEDICAL VIROLOGY 92(2) 210-218 2020年2月
Ribavirin induces hepatitis C virus genome mutations in chronic hepatitis patients who failed to respond to prior daclatasvir plus asunaprevir therapy

Yuhei Saito, Michio Imamura, Takuro Uchida, Mitsutaka Osawa, Yuji Teraoka, Hatsue Fujino, Takashi Nakahara, Atsushi Ono, Eisuke Murakami, Tomokazu Kawaoka …

JOURNAL OF MEDICAL VIROLOGY 2019年10月
Alcohol Use Disorders Identification Test-consumption Predicts the Risk of Excessive Alcohol Consumption After Liver Transplantation.

Yano T, Ohira M, Sakamoto R, Narisada A, Shimizu S, Tahara H, Ide K, Kobayashi T, Imamura M, Machino A …

Transplantation proceedings 51(6) 1934-1938 2019年7月査読有り
Efficacy of glecaprevir and pibrentasvir treatment for genotype 1b hepatitis C virus drug resistance-associated variants in humanized mice

Osawa, Mitsutaka, Uchida, Takuro, Imamura, Michio, Teraoka, Yuji, Fujino, Hatsue, Nakahara, Takashi, Ono, Atsushi, Murakami, Eisuke, Kawaoka, Tomokazu, Miki, Daiki …

JOURNAL OF GENERAL VIROLOGY 100(7) 1123-1131 2019年7月査読有り
Regulation of the Hepatitis B virus replication and gene expression by the multi-functional protein TARDBP

Makokha, Grace Naswa, Abe-Chayama, Hiromi, Chowdhury, Sajeda, Hayes, C. Nelson, Tsuge, Masataka, Yoshimaz, Tadahiko, Ishida, Yuji, Zhang, Yizhou, Uchida, Takuro …

SCIENTIFIC REPORTS 9 2019年6月11日査読有り
HCV-Induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic Response.

Hamdane N, Jühling F, Crouchet E, El Saghire H, Thumann C, Oudot MA, Bandiera S, Saviano A, Ponsolles C, Roca Suarez AA …

Gastroenterology 156(8) 2313-2329.e7 2019年6月査読有り
Reply: Hepatectomy versus stereotactic body radiotherapy for primary early hepatocellular carcinoma: A propensity -matched analysis in a single institution.

Nakano R, Ohira M, Kobayashi T, Ide K, Tahara H, Kuroda S, Shimizu S, Kimura T, Nagata Y, Aikata H …

Surgery 165(5) 1054-1057 2019年5月査読有り

もっとみる

MISC

PERMISSION OF HEPATITIS B VIRUS INFECTION IN Jak3KORag2KO MOUSE

Yuji Teraoka, Michio Imamura, Takuro Uchida, Kazuki Ohya, Mitsutaka Osawa, Kei Morio, Hatsue Fujino, Takashi Nakahara, Atsushi Ono, Eisuke Murakami …

HEPATOLOGY 70 617A-617A 2019年10月
GENETIC POLYMORPHISM OF IP-10, NOT IFNL4 OR HLA-DPS, AFFECTS LIVER INFLAMMATION IN CHRONIC HEPATITIS B PATIENTS

Daiki Miki, Masataka Tsuge, Hiromi Abe-Chayama, Nelson Hayes, Hatsue Fujino, Grace Naswa Makokha, Atsushi Ono, Takashi Nakahara, Eisuke Murakami, Masami Yamauchi …

HEPATOLOGY 70 412A-413A 2019年10月
ASSOCIATION OF FNDC5, PNPLA3 AND TM6SF2 POLYMORPHISMS WITH HEPATIC STEATOSIS IN NAFLD PATIENTS

Daiki Miki, Takashi Nakahara, Eisuke Murakami, Hiromi Abe-Chayama, Hatsue Fujino, Atsushi Ono, Masami Yamauchi, Tomokazu Kawaoka, Masataka Tsuge, Akira Hiramatsu …

HEPATOLOGY 70 1050A-1051A 2019年10月
A COMPREHENSIVE ANALYSIS OF A WIDE RANGE OF LIVER DISEASES BY 16S rRNA SEQUENCING REVEALS CHARACTERISTIC PATTERNS OF GUT MICROBIOTA IN EACH ETIOLOGY

Daiki Miki, Yumi Shimomura, Nelson Hayes, Hiromi Abe-Chayama, Hatsue Fujino, Maiko Numba, Takashi Nakahara, Atsushi Ono, Eisuke Murakami, Masami Yamauchi …

HEPATOLOGY 70 1163A-1164A 2019年10月
INDEPENDENT IMPACT OF POLYMORPHISM IN IRF5 AS WELL AS STAT4 ON HBV-RELATED HEPATOCARCINOGENESIS

Daiki Miki, Masataka Tsuge, Hiromi Abe-Chayama, Nelson Hayes, Hatsue Fujino, Grace Naswa Makokha, Atsushi Ono, Takashi Nakahara, Eisuke Murakami, Masami Yamauchi …

HEPATOLOGY 70 1190A-1190A 2019年10月
DIFFERENTIAL EFFECTS OF HOST GENETIC FACTORS ON HCV PERSISTENCE ACCORDING TO HCV GENOTYPES

Daiki Miki, Tomokazu Kawaoka, Nelson Hayes, Hiromi Abe-Chayama, Hatsue Fujino, Grace Naswa Makokha, Atsushi Ono, Takashi Nakahara, Eisuke Murakami, Masami Yamauchi …

HEPATOLOGY 70 1008A-1008A 2019年10月
EXPLORATORY ANALYSIS OF BIOMARKERS ASSOCIATED WITH CLINICAL OUTCOMES OF LENVATINIB IN HEPATOCELLULAR CARCINOMA

Atsushi Ono, Hiroshi Aikata, Masami Yamauchi, Kenichiro Kodama, Daiki Miki, Waka Ohishi, Yuji Teraoka, Hatsue Fujino, Takashi Nakahara, Eisuke Murakami …

HEPATOLOGY 70 228A-228A 2019年10月
RESISTANCE ANALYSIS FOR GLECAPREVIR AND PIBRENTASVIR ON GENOTYPE 1b HEPATITIS C VIRUS INFECTION IN SUBGENOMIC REPLICON SYSTEMS AND HUMAN HEPATOCYTE TRANSPLANTED MICE

Mitsutaka Osawa, Michio Imamura, Takuro Uchida, Yuji Teraoka, Hatsue Fujino, Takashi Nakahara, Atsushi Ono, Eisuke Murakami, Tomokazu Kawaoka, Daiki Miki …

HEPATOLOGY 70 988A-989A 2019年10月
Regulation of the Hepatitis B Virus Gene Expression and Replication By the Multi-Functional Protein Tardbp

Grace Naswa Makokha, Kazuaki Chayama, Hiromi Abe-Chayama, Masataka Tsuge, Takuro Uchida, Yuji Ishida

HEPATOLOGY 68 318A-318A 2018年10月
Association of TLL1 Polymorphism with Development of Hepatocellular Carcinoma after Hepatitis C Virus Eradication and Fibrosis Severity

Daiki Miki, Tomokazu Kawaoka, Nagaoki Yuko, Nelson Hayes, Atsushi Ono, Takashi Nakahara, Eisuke Murakami, Masami Yamauchi, Masataka Tsuge, Akira Hiramatsu …

HEPATOLOGY 68 597A-597A 2018年10月
Efficacy of Glecaprevir and Pibrentasvir Treatment for Hepatitis C Virus Drug Resistance-Associated Variants in Humanized Mice

Mitsutaka Osawa, Takuro Uchida, Michio Imamura, Yuji Teraoka, Masataka Tsuge, Hiromi Abe-Chayama, Grace Naswa Makokha, Hiroshi Aikata, Yuji Ishida, Chise Tateno …

HEPATOLOGY 68 411A-412A 2018年10月
Prevalence of NS5A Resistance Associated Variants in NS5A Inhibitor Treatment Failures and an Effective Treatment for NS5A-P32 Deleted Hepatitis C Virus in Humanized Mice

Yuji Teraoka, Takuro Uchida, Michio Imamura, Mitutaka Osawa, Tomokazu Kawaoka, Masataka Tsuge, Hiromi Abe-Chayama, Nelson Hayes, Grace Naswa Makokha, Hiroshi Aikata …

HEPATOLOGY 68 384A-384A 2018年10月
The Influence of Histone Methyltransferase SUV39h1 on Hepatitis B Virus-Related Hepatocarcinogenesis

Ken Tsushima, Masataka Tsuge, Takuro Uchida, Michio Imamura, Mitutaka Osawa, Yuji Teraoka, Hiromi Abe-Chayama, Grace Naswa Makokha, Hiroshi Aikata, Kazuaki Chayama

HEPATOLOGY 68 328A-329A 2018年10月
A Novel Jak3KORag2KO Chimeric Mouse Model for the Study of Hepatitis Virus Virology

Takuro Uchida, Michio Imamura, Yuji Ishida, Chise Tateno, Mitsutaka Osawa, Yuji Teraoka, Masataka Tsuge, Hiromi Abe-Chayama, Grace Naswa Makokha, Hiroshi Aikata …

HEPATOLOGY 68 587A-587A 2018年10月
Hepatitis B virus up-regulates IL8 expression via endoplasmic reticulum stress and leads to suppress interferon responsiveness

Masataka Tsuge, Nobuhiko Hiraga, Takuro Uchida, Eisuke Murakami, Hiromi Abe-Chayama, Daiki Miki, Michio Imamura, Yoshiiku Kawakami, Hiroshi Aikata, Hidenori Ochi …

HEPATOLOGY 66 800A-801A 2017年10月
Serum HMGB1 concentrations is a useful predictor of extreme poor prognosis for advanced hepatocellular carcinoma treated with sorafenib and hepatic arterial infusion chemotherapy

Atsushi Ono, Kazuhiko Masuda, Hiroshi Aikata, Tomokazu Kawaoka, Nelson Hayes, Takashi Nakahara, Daiki Miki, Masataka Tsuge, Akira Hiramatsu, Michio Imamura …

HEPATOLOGY 66 764A-764A 2017年10月
Persistent Loss of HBV Markers in Serum without Cellular Immunity by Combination of PEG-IFN Plus ETV Therapy in Humanized Mice

Takuro Uchida, Michio Imamura, C. Nelson Hayes, Nobuhiko Hiraga, Masataka Tsuge, Hiromi Abe-Chayama, Grace N. Makokha, Yuji Ishida, Chise Tateno, Kazuaki Chayama

HEPATOLOGY 66 789A-789A 2017年10月
Characterizing the early immune response to hepatitis B virus infection using the human hepatocyte chimeric mouse model

Nelson Hayes, Sakura Akamatsu, Masataka Tsuge, Daiki Miki, Hiromi Abe-Chayama, Michio Imamura, Kazuaki Chayama

HEPATOLOGY 66 786A-786A 2017年10月
TARDBP regulates HBV transcription and replication through interaction with the core promoter

Grace N. Makokha, Hiromi Abe-Chayama, Masataka Tsuge, Nelson Hayes, Takuro Uchida, Tadahiko Yoshima, Yuji Ishida, Kazuaki Chayama

HEPATOLOGY 66 784A-785A 2017年10月
Protease inhibitor resistance remains even after mutant strains become undetectable using ultra-deep sequencing

Hiromi Kan, Michio Imamura, Nobuhiko Hiraga, C. Nelson Hayes, Takuro Uchida, Eisuke Miyaki, Masataka Tsuge, Hiromi Abe-Chayama, Hiroshi Aikata, Daiki Miki …

HEPATOLOGY 64 430A-430A 2016年10月

もっとみる

共同研究・競争的資金等の研究課題

B型肝炎ウイルス持続感染の完治を目指すHBV特異的Tscmを用いた新規治療の探索

日本学術振興会科学研究費助成事業基盤研究(C) 2022年4月 - 2025年3月

茶山弘美
ヒト肝細胞キメラマウスモデルとヒト組織学的進展例材料を用いたNASHの研究

日本学術振興会科学研究費助成事業基盤研究(A) 2021年4月 - 2024年3月

茶山一彰, 三木大樹, Hayes C.Nelson, 茶山弘美
2本鎖DNAを使用せず高度の安全性を保証する遺伝子治療の開発

日本学術振興会科学研究費助成事業挑戦的研究(開拓) 2017年6月 - 2020年3月

茶山一彰, 三木大樹, 茶山弘美, 林亮平
ヒト肝細胞キメラマウスとバキュロウイルスを用いた遺伝病モデルの創生

日本学術振興会科学研究費助成事業基盤研究(C) 2014年4月 - 2017年3月

茶山弘美

茶山弘美

基本情報

研究分野

受賞

論文

MISC

共同研究・競争的資金等の研究課題

メニュー

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