hiroyasu akatsu

Profile Information

Affiliation: National Center for Geriatrics and Gerontrogy

Degree: 医学(名古屋市立大学医学研究科)

J-GLOBAL ID: 201101037522318490
researchmap Member ID: B000001774

Major Research Interests

Research Areas

Life sciences / Internal medicine - General / 老年医学/神経病理学/臨床栄養学/フレイル予防/認知症早期診断・予防

Research History

Apr, 2024 - Present

National Center for Geriatrics and Gerontrogy
Aug, 2023 - Mar, 2024

総合診療医学・総合内科, 名古屋市立大学医薬学総合研究院大学院医学研究科・医学部

Awards

Papers

175

Polygenic effects on the risk of Alzheimer’s disease in the Japanese population

Masataka Kikuchi, Akinori Miyashita, Norikazu Hara, Kensaku Kasuga, Yuko Saito, Shigeo Murayama, Akiyoshi Kakita, Hiroyasu Akatsu, Kouichi Ozaki, Shumpei Niida …

Alzheimer's Research & Therapy, 16(1), Feb 27, 2024
Marked alteration of phosphoinositide signaling‐associated molecules in postmortem prefrontal cortex with bipolar disorder

Mizuki Hino, Yasuto Kunii, Risa Shishido, Atsuko Nagaoka, Junya Matsumoto, Hiroyasu Akatsu, Yoshio Hashizume, Hideki Hayashi, Akiyoshi Kakita, Hiroaki Tomita …

Neuropsychopharmacology Reports, Jan 22, 2024
日本人におけるLATE,PART病理確定例の認知症感受性遺伝子・バリアント解析

金田大太, 宮下哲典, 原範和, 大日方藍, 月江珠緒, 長谷川舞衣, 五十嵐一也, 春日健作, 赤津裕康, 池内健 …

Dementia Japan, 37(4) 658-658, Oct, 2023
Lipid-correlated alterations in the transcriptome are enriched in several specific pathways in the postmortem prefrontal cortex of Japanese patients with schizophrenia.

Wataru Arihisa, Takeshi Kondo, Katsushi Yamaguchi, Junya Matsumoto, Hiroki Nakanishi, Yasuto Kunii, Hiroyasu Akatsu, Mizuki Hino, Yoshio Hashizume, Shumpei Sato …

Neuropsychopharmacology reports, 43(3) 403-413, Sep, 2023
Effect of ankle weight loading and walking speed on metabolic and neuromuscular responses and lower limb kinematics during treadmill walking

Shun Kunugi, Hiroyasu Akatsu, Kohei Watanabe

Sport Sciences for Health, Jun 16, 2023 Peer-reviewed
Effects of home-based bodyweight squat training on neuromuscular properties in community-dwelling older adults.

Tetsuya Hirono, Shun Kunugi, Akane Yoshimura, Saeko Ueda, Ryokichi Goto, Hiroyasu Akatsu, Kohei Watanabe

Aging clinical and experimental research, 35(5) 1043-1053, May, 2023
Acute effects of ankle weight loading on regional activity of rectus femoris muscle and lower-extremity kinematics during walking in older adults

Shideh Narouei, Hiroyasu Akatsu, Kohei Watanabe

Kinesiology, 55(1) 13-20, 2023
Detection of Physical Frailty Status of Middle-Aged and Elderly People Using Gait Features Based on 3-Axis Acceleration Sensors

Saki Nakamura, Akira Masuo, Jun Takeo, Takuto Sakuma, Shohei Kato, Kohei Watanabe, Yoshihiro Kawade, Toshie Manabe, Hiroyasu Akatsu

IEEJ Transactions on Electronics, Information and Systems, 142(12) 1262-1268, Dec 1, 2022
Knowledge, Attitudes, and Practices Survey among Nursing Care Workers Involved in Caring for Older Adults during the Early Stage of the COVID-19 Pandemic in Japan.

Dan Kambayashi, Toshie Manabe, Masayoshi Hirohara, Hiroyasu Akatsu

International journal of environmental research and public health, 19(20), Oct 11, 2022
Association of nutritional support with survival-time in hospitalized older patients with dysphagia: a retrospective study.

Toshie Manabe, Yoshiyuki Masaki, Yoshiko Yamamoto, Kayoko Yamamoto, Osamu Kohashi, Takayuki Yamamoto, Hirotaka Ohara, Hiroyasu Akatsu

Annals of nutrition & metabolism, 78(5) 281-286, Jul 13, 2022
Correction to: Ultrastructural and biochemical classification of pathogenic tau, α-synuclein and TDP-43.

Airi Tarutani, Tadashi Adachi, Hiroyasu Akatsu, Yoshio Hashizume, Kazuko Hasegawa, Yuko Saito, Andrew C Robinson, David M A Mann, Mari Yoshida, Shigeo Murayama …

Acta neuropathologica, 144(1) 165-165, Jul, 2022
A Histochemical Analysis of Neurofibrillary Tangles in Olfactory Epithelium, a Study Based on an Autopsy Case of Juvenile Alzheimer's Disease.

Shino Shimizu, Ichiro Tojima, Keigo Nakamura, Hideaki Kouzaki, Takeshi Kanesaka, Norihiro Ogawa, Yoshio Hashizume, Hiroyasu Akatsu, Akira Hori, Ikuo Tooyama …

Acta histochemica et cytochemica, 55(3) 93-98, Jun 29, 2022
Expression of Transferrin Protein and Messenger RNA in Neural Cells from Mouse and Human Brain Tissue.

Eriko Abe, Takashi J Fuwa, Kyoka Hoshi, Takashi Saito, Takenobu Murakami, Masakazu Miyajima, Norihiro Ogawa, Hiroyasu Akatsu, Yoshio Hashizume, Yasuhiro Hashimoto …

Metabolites, 12(7), Jun 26, 2022
Effect of Ankle Weights as a Frailty Prevention Strategy in the Community-Dwelling Elderly: A Preliminary Report.

Hiroyasu Akatsu, Toshie Manabe, Yoshihiro Kawade, Yoshiyuki Masaki, Shigeru Hoshino, Takashi Jo, Shinya Kobayashi, Tomihiro Hayakawa, Hirotaka Ohara

International journal of environmental research and public health, 19(12), Jun 15, 2022
Ultrastructural and biochemical classification of pathogenic tau, α-synuclein and TDP-43.

Airi Tarutani, Tadashi Adachi, Hiroyasu Akatsu, Yoshio Hashizume, Kazuko Hasegawa, Yuko Saito, Andrew C Robinson, David M A Mann, Mari Yoshida, Shigeo Murayama …

Acta neuropathologica, 143(6) 613-640, Jun, 2022
Experimental design of a stable isotope labeling derivatized UHPLC-MS/MS method for the detection/quantification of primary/secondary bile acids in biofluids.

Yoshio Muguruma, Ryosuke Nagatomo, Shihori Kamatsuki, Katsuyuki Miyabe, Go Asano, Hiroyasu Akatsu, Koichi Inoue

Journal of pharmaceutical and biomedical analysis, 209 114485-114485, Feb 5, 2022
Regional neuromuscular regulation within rectus femoris muscle following three-month limb-loaded walking in older adults

Shideh Narouei, Hiroyasu Akatsu, Kohei Watanabe

Sports Medicine and Health Science, 4(1) 38-43, Dec, 2021
Distinct phosphorylation profiles of tau in brains of patients with different tauopathies

Nastaran Samimi, Govinda Sharma, Taeko Kimura, Tomoyasu Matsubara, Anni Huo, Kurumi Chiba, Yuko Saito, Shigeo Murayama, Hiroyasu Akatsu, Yoshio Hashizume …

Neurobiology of Aging, 108 72-79, Dec, 2021
Transferrin Biosynthesized in the Brain Is a Novel Biomarker for Alzheimer's Disease.

Kyoka Hoshi, Hiromi Ito, Eriko Abe, Takashi J Fuwa, Mayumi Kanno, Yuta Murakami, Mitsunari Abe, Takenobu Murakami, Akioh Yoshihara, Yoshikazu Ugawa …

Metabolites, 11(9), Sep 10, 2021
Characterization of a Conformation-Restricted Amyloid β Peptide and Immunoreactivity of Its Antibody in Human AD brain.

Yusuke Kageyama, Yumi Irie, Yuka Matsushima, Tatsuya Segawa, Jean-Pierre Bellier, Kumi Hidaka, Hiroshi Sugiyama, Daita Kaneda, Yoshio Hashizume, Hiroyasu Akatsu …

ACS chemical neuroscience, 12(18) 3418-3432, Aug 31, 2021

Misc.

467

遺伝性血管性浮腫(Hereditary angioedema:HAE)診療ガイドライン改訂2023年版

堀内孝彦, 大澤勲, 宮田敏行, 赤津裕康, 今井優樹, 大谷克城, 奥健志, 関根英治, 塚本浩, 中尾実樹 …

補体, 60(1) 23-23, Aug, 2023
【補体と疾患-いま補体がおもしろい-】最近の話題筋萎縮性側索硬化症,アルツハイマー型認知症と補体

赤津裕康

日本臨床, 80(11) 1859-1864, Nov, 2022
MCIとアルツハイマー病における凝固線溶異常第Xa因子活性と血液バイオマーカー変化

劉珊, 井上真, 目野浩二, 伊藤ひとみ, 是永龍巳, 鈴木秀昭, 松川則之, 赤津裕康, 朝田隆, 新井哲明 …

老年精神医学雑誌, 33(増刊II) 328-328, Nov, 2022
18F-Florbetaben撮像症例の臨床画像病理連関福祉村ブレインバンク報告

金田大太, 赤津裕康, 櫻井圭太, 尾内康臣, 村山繁雄, 橋詰良夫

老年精神医学雑誌, 33(増刊II) 335-335, Nov, 2022
地域在住高齢者の自宅スクワットトレーニングが神経筋機能に及ぼす影響

廣野哲也, 功刀峻, 吉村茜, 上田紗笑子, 後藤亮吉, 赤津裕康, 渡邊航平

日本サルコペニア・フレイル学会雑誌, 6(Suppl.) 157-157, Oct, 2022
地域高齢者へのアンクルウェイト介入効果の検証

赤津裕康, 間辺利江, 川出義浩, 正木克由規, 星野茂, 小林真哉, 城卓志, 早川富博, 大原弘隆

日本サルコペニア・フレイル学会雑誌, 6(Suppl.) 174-174, Oct, 2022
MCIとアルツハイマー病における凝固線溶異常第Xa因子活性と血液バイオマーカー変化

劉珊, 井上真, 目野浩二, 伊藤ひとみ, 是永龍巳, 鈴木秀昭, 松川則之, 赤津裕康, 朝田隆, 新井哲明 …

Dementia Japan, 36(4) 789-789, Oct, 2022
18F-Florbetaben撮像症例の臨床画像病理連関福祉村ブレインバンク報告

金田大太, 赤津裕康, 櫻井圭太, 尾内康臣, 村山繁雄, 橋詰良夫

Dementia Japan, 36(4) 792-792, Oct, 2022
抗体価測定により新型コロナウイルス感染症が示唆された1例

赤津裕康, 平松克仁, 田中創始, 間辺利江, 荒川和幸, 兼松孝好, 長谷川千尋, 久米充芳, 丸山光生, 中村敦 …

感染症学雑誌, 96(5) 204-209, Sep, 2022
死後脳脊髄液および血清試料を用いたUHPLC-MS/MS法によるアルツハイマー病およびレビー小体型認知症の代謝経路の解明(Application of a UHPLC-MS/MS Method to Investigate the Metabolic Pathways of Alzheimer's Disease and Dementia with Lewy Bodies Using Postmortem Cerebrospinal Fluid and Serum Samples)

六車宜央, 赤津裕康, 井之上浩一

JSBMS Letters, 47(Suppl.) 36-36, Aug, 2022
ストレス社会と質量分析高齢者、地域住民のデジタルブラッドデータベース構築を目指した医療系学生教育を並走させた地域コホート体制の構築

赤津裕康

JSBMS Letters, 47(Suppl.) 49-49, Aug, 2022
ストレス社会と質量分析ワイドターゲットメタボロミクスおよび機械学習によるヒト体内代謝環境の解析

六車宜央, 赤津裕康, 井之上浩一

JSBMS Letters, 47(Suppl.) 50-50, Aug, 2022
安定同位体誘導体化LC-MS/MSを用いたヒト血清中におけるAGEsの一斉分析法の開発アルツハイマー型認知症への応用

木下真千佳, 六車宜央, 赤津裕康, 井之上浩一

JSBMS Letters, 47(Suppl.) 115-115, Aug, 2022
安定同位体誘導体化LC-MS/MSを用いたヒト胆汁中における腸内細菌叢由来代謝物の解析

金子東暉, 六車宜央, 宮部勝之, 赤津裕康, 井之上浩一

JSBMS Letters, 47(Suppl.) 117-117, Aug, 2022
Application of a UHPLC-MS/MS Method to Investigate the Metabolic Pathways of Alzheimer's Disease and Dementia with Lewy Bodies Using Postmortem Cerebrospinal Fluid and Serum Samples(和訳中)

六車宜央, 赤津裕康, 井之上浩一

JSBMS Letters, 47(Suppl.) 36-36, Aug, 2022
ストレス社会と質量分析高齢者、地域住民のデジタルブラッドデータベース構築を目指した医療系学生教育を並走させた地域コホート体制の構築

赤津裕康

JSBMS Letters, 47(Suppl.) 49-49, Aug, 2022
ストレス社会と質量分析ワイドターゲットメタボロミクスおよび機械学習によるヒト体内代謝環境の解析

六車宜央, 赤津裕康, 井之上浩一

JSBMS Letters, 47(Suppl.) 50-50, Aug, 2022
安定同位体誘導体化LC-MS/MSを用いたヒト血清中におけるAGEsの一斉分析法の開発アルツハイマー型認知症への応用

木下真千佳, 六車宜央, 赤津裕康, 井之上浩一

JSBMS Letters, 47(Suppl.) 115-115, Aug, 2022
安定同位体誘導体化LC-MS/MSを用いたヒト胆汁中における腸内細菌叢由来代謝物の解析

金子東暉, 六車宜央, 宮部勝之, 赤津裕康, 井之上浩一

JSBMS Letters, 47(Suppl.) 117-117, Aug, 2022
抗体価測定によりSARS-CoV-2感染が示唆された一例

中村敦, 田中創始, 赤津裕康, 荒川和幸, 兼松孝好, 長谷川千尋, 大原弘隆, 鈴木幹三

日本化学療法学会雑誌, 70(Suppl.A) 301-301, May, 2022

Books and Other Publications

特集アルツハイマー病の早期診療法の現状

赤津裕康 (Role: Editor, 特集にあたってIntroduction)

BIO INDUSTRY, Jun, 2018
治療が劇的にうまくいく高齢者の栄養はじめの一歩

赤津裕康 (Role: Contributor, 長期療養型病床における高齢者の栄養管理)

羊土社, 2013
老年期認知症ナビゲーター

赤津裕康 (Role: Contributor, αシヌクレインと認知症)

メディカルレビュー社, 2006

Professional Memberships

Research Projects

Clarifying beneficial effects of statins to improve survival of patients with cholangiocarcinoma using the analysis of bile metabolome

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2025
Development of AI technology to detect prion activity of pathogenic proteins in nasal mucosa and its application to diagnosis of dementia

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Pioneering), Grant-in-Aid for Challenging Research (Pioneering), Japan Society for the Promotion of Science, Jul, 2020 - Mar, 2024
Creating a fall prevention program that the elderly can evaluate their walk-style by developing our three-dimensional acceleration sensor

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2024
A Cross-Sectional Study on Disease and Regional Diversity of Cognitive Impairment in Elderly Using Speech Analysis and Cerebral Blood Flow Activation

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2024
International cooperative study for spatial-temporal disease clustering and risk factors on emerging infectious diseases

Grants-in-Aid for Scientific Research Fund for the Promotion of Joint International Research (Fostering Joint International Research (B)), Fund for the Promotion of Joint International Research (Fostering Joint International Research (B)), Japan Society for the Promotion of Science, Oct, 2020 - Mar, 2023
ラクトフェリンによる炎症性腸疾患の発症予防と寛解維持および発がん予防効果

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2019 - Mar, 2022

田中創始, 津田洋幸, 赤津裕康, 大原弘隆, 兼松孝好, 正木克由規, 荒川和幸
Study of two-step amyloid-beta accumulation in human brains

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

Shinohara Mitsuru
Simultaneous analysis of Aß oligomers, Aß fibrils and phosphrylated tau protein using fluroine-MRI

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2021

Tooyama Ikuo
Development of online system about Advanced Directive of Living Will and its efficacy assessment

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2021
コホート・生体試料支援プラットフォーム

科学研究費助成事業新学術領域研究（研究領域提案型）『学術研究支援基盤形成』, 新学術領域研究（研究領域提案型）『学術研究支援基盤形成』, 日本学術振興会, 2016 - 2021

今井浩三, 若井建志, 村上善則, 松尾恵太郎, 三上春夫, 鈴木貞夫, 喜多義邦, 渡辺能行, 田中恵太郎, 嶽崎俊郎, 栗木清典, 古庄憲浩, 有澤孝吉, 玉腰暁子, 今田恒夫, 武林亨, 三浦克之, 成松宏人, 鈴木康司, 村山繁雄, 高尾昌樹, 赤津裕康, 齊藤祐子, 矢部博興, 中杤昌弘, 清水厚志, 醍醐弥太郎, 高橋隆, 宮城洋平, 渡邉俊樹, 安井寛, 田中英夫, 内藤真理子, 大中佳三, 森満, 川崎良
The research of pathological condition for clinical diagnosis of tangle only dementia

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

Hiroyasu Akatsu
A study to elucidate mechanism, by which periodontists inducing memory impairment and to determine effect of its intervention on progression of dementia.

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

Michikawa Makoto, Shirono Miwa, Yoshioka Hiroo
Verification of the sensor built-in ankle weight (Power Walk) and the effect on prevention of frailty and behavior change

2018 - 2019

Education

1992 - 1996

Graduate School of Medical Sciences, Nagoya City University
1985 - 1991

Nagoya City University

Committee Memberships

Dec, 2021 - Present

中部ブロック支部代議員, 日本プライマリ・ケア連合学会
Sep, 2020 - Present

Geriatrics & Gerontology International(GGI) Associate Editor
Sep, 2020 - Present

理事, 補体学会
Jan, 2021

学会誌編集副委員長, 日本補体学会

Industrial Property Rights

特開2021-003248 転倒予防システム

加藤周平, 森啓悟, 赤津裕康
WO2018-221212 アルツハイマー病バイオマーカー

道川誠, 赤津裕康, アブドラモハンマド, 松原悦朗, 木村成志

Profile Information

Major Research Interests

Research Areas

Research History

Awards

Papers

Misc.

Books and Other Publications

Professional Memberships

Research Projects

Education

Committee Memberships

Industrial Property Rights

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