Junichi MARUYAMA

Profile Information

Affiliation: Researcher, Center for Integrative Medical Sciences, Laboratory for Integrated Cellular Systems, RIKEN

Degree: Ph.D.(The University of Tokyo)

Researcher number: 30723639
J-GLOBAL ID: 201501015947692767
researchmap Member ID: B000250377

External link: https://kaken.nii.ac.jp/d/r/30723639.ja.html

Research Interests

Research Areas

Research History

Jun, 2021 - Present

Researcher, Center for Integrative Medical Sciences, Laboratory for Integrated Cellular Systems, RIKEN
Jan, 2013 - May, 2021

Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
Apr, 2012 - Dec, 2012

Graduate School of Pharmaceutical Sciences, The University of Tokyo

Education

Apr, 2007 - Mar, 2012

Graduate School of Pharmaceutical Sciences, The University of Tokyo
Apr, 2005 - Mar, 2007

Department of Pharmacy, Faculty of Pharmaceutical Sciences, The University of Tokyo
Apr, 2003 - Mar, 2005

College of Arts and Sciences, The University of Tokyo

Awards

Mar, 2024

IMSリトリートFY2023 Best Presentation Award
Nov, 2016

第39回日本分子生物学会年会優秀ポスター賞
Sep, 2011

第84回日本生化学会大会鈴木紘一メモリアル賞

Papers

Transomics2cytoscape: an automated software for interpretable 2.5-dimensional visualization of trans-omic networks.

Kozo Nishida, Junichi Maruyama, Kazunari Kaizu, Koichi Takahashi, Katsuyuki Yugi

NPJ systems biology and applications, 10(1) 16, Feb 19, 2024 Peer-reviewed
Protein kinase Cα activation switches YAP1 from TEAD‐mediated signaling to p73‐mediated signaling

Caleb Kwame Sinclear, Junichi Maruyama, Shunta Nagashima, Kyoko Arimoto‐Matsuzaki, Joshua Agbemefa Kuleape, Hiroaki Iwasa, Hiroshi Nishina, Yutaka Hata

Cancer Science, 113(4) 1305-1320, Apr, 2022 Peer-reviewed
DNA damage triggers the nuclear accumulation of RASSF6 tumor suppressor protein via CDK9 and BAF53 to regulate p53-target gene transcription

Joshua Agbemefa Kuleape, Shakhawoat Hossain, Caleb Kwame Sinclear, Takanobu Shimizu, Hiroaki Iwasa, Junichi Maruyama, Kyoko Arimoto-Matsuzaki, Hiroshi Nishina, Yutaka Hata

Molecular and Cellular Biology, 42(2) e0031021, Feb 17, 2022 Peer-reviewed
Meta-analysis of transcriptional regulatory networks for lipid metabolism in neural cells from schizophrenia patients based on an open-source intelligence approach

Lisa Okamoto, Soyoka Watanabe, Senka Deno, Xiang Nie, Junichi Maruyama, Masaru Tomita, Atsushi Hatano, Katsuyuki Yugi

Neuroscience Research, 175 82-97, Feb, 2022 Peer-reviewed
Characterization of mouse embryonic fibroblasts derived from Rassf6 knockout mice reveals the implication of Rassf6 in the regulation of NF-κB signaling.

Mayu Morishita, Kyoko Arimoto-Matsuzaki, Masami Kitamura, Kyohei Niimura, Hiroaki Iwasa, Junichi Maruyama, Yuichi Hiraoka, Kohei Yamamoto, Masanobu Kitagawa, Norio Miyamura …

Genes to cells : devoted to molecular & cellular mechanisms, 26(12) 999-1013, Dec, 2021 Peer-reviewed
CSE1L promotes nuclear accumulation of transcriptional coactivator TAZ and enhances invasiveness of human cancer cells

Shunta Nagashima, Junichi Maruyama, Kaori Honda, Yasumitsu Kondoh, Hiroyuki Osada, Makiko Nawa, Ken-ichi Nakahama, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Haruhiko Sugimura …

Journal of Biological Chemistry, 297(1) 100803-100803, May, 2021 Peer-reviewedCorresponding author
Doublecortin-like kinase 1 expression is induced by alternative NF-κB signaling in human lung cancer cells

Yuxiong Lu, Junichi Maruyama, Haruhiko Sugimura, Yutaka Hata

Journal of Medical and Dental Sciences, 68 39-48, Mar, 2021 Peer-reviewedCorresponding author
Heat shock induces the nuclear accumulation of YAP1 via SRC

Xinliang Jiang, Junichi Maruyama, Hiroaki Iwasa, Kyoko Arimoto-Matsuzaki, Hiroshi Nishina, Yutaka Hata

Experimental Cell Research, 399(1) 112439-112439, Feb, 2021 Peer-reviewedCorresponding author
The RAS-interacting chaperone UNC119 drives the RASSF6-MDM2-p53 axis and antagonizes RAS-mediated malignant transformation.

Takanobu Shimizu, Takeshi Nakamura, Hironori Inaba, Hiroaki Iwasa, Junichi Maruyama, Kyoko Arimoto-Matsuzaki, Takao Nakata, Hiroshi Nishina, Yutaka Hata

The Journal of biological chemistry, 295(32) 11214-11230, Jun 18, 2020 Peer-reviewed
Characterization of a novel compound that promotes myogenesis via Akt and transcriptional co-activator with PDZ-binding motif (TAZ) in mouse C2C12 cells.

Manami Kodaka, Fengju Mao, Kyoko Arimoto-Matsuzaki, Masami Kitamura, Xiaoyin Xu, Zeyu Yang, Kentaro Nakagawa, Junichi Maruyama, Kana Ishii, Chihiro Akazawa …

PloS one, 15(4) e0231265, 2020 Peer-reviewed
Discovery of a Small Molecule to Increase Cardiomyocytes and Protect the Heart After Ischemic Injury.

Hironori Hara, Norifumi Takeda, Masaki Kondo, Mio Kubota, Tatsuo Saito, Junichi Maruyama, Takayuki Fujiwara, Sonoko Maemura, Masamichi Ito, Atsuhiko T Naito …

JACC. Basic to translational science, 3(5) 639-653, Oct, 2018 Peer-reviewed
The RASSF6 Tumor Suppressor Protein Regulates Apoptosis and Cell Cycle Progression via Retinoblastoma Protein.

Hossain S, Iwasa H, Sarkar A, Maruyama J, Arimoto-Matsuzaki K, Hata Y

Molecular and cellular biology, 38(17), Sep, 2018 Peer-reviewed
UNC119 is a binding partner of tumor suppressor Ras-association domain family 6 and induces apoptosis and cell cycle arrest by MDM2 and p53.

Iwasa H, Sarkar A, Shimizu T, Sawada T, Hossain S, Xu X, Maruyama J, Arimoto-Matsuzaki K, Withanage K, Nakagawa K …

Cancer science, 109(9) 2767-2780, Sep, 2018 Peer-reviewed
Novel YAP1 Activator, Identified by Transcription-Based Functional Screen, Limits Multiple Myeloma Growth

Junichi Maruyama, Kazutoshi Inami, Fumiyoshi Michishita, Xinliang Jiang, Hiroaki Iwasa, Kentaro Nakagawa, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Norio Miyamura, Jun Hirayama …

Molecular Cancer Research, 16(2) 197-211, Feb 1, 2018 Peer-reviewedLead author
BCL-XL binds and antagonizes RASSF6 tumor suppressor to suppress p53 expression

Xiaoyin Xu, Hiroaki Iwasa, Shakhawoat Hossain, Aradhan Sarkar, Junichi Maruyama, Kyoko Arimoto-Matsuzaki, Yutaka Hata

GENES TO CELLS, 22(12) 993-1003, Dec, 2017 Peer-reviewed
Application of split-GFP reassembly assay to study myogenesis and myofusion in vitro

Manami Kodaka, Xiaoyin Xu, Zeyu Yang, Junichi Maruyama, Yutaka Hata

Methods in Molecular Biology, 1668 127-134, 2017 Peer-reviewed
Domain analysis of Ras-association domain family member 6 upon interaction with MDM2

Aradhan Sarkar, Hiroaki Iwasa, Shakhawoat Hossain, Xiaoyin Xu, Takeru Sawada, Takanobu Shimizu, Junichi Maruyama, Kyoko Arimoto-Matsuzaki, Yutaka Hata

FEBS LETTERS, 591(2) 260-272, Jan, 2017 Peer-reviewed
Validation of chemical compound library screening for transcriptional co-activator with PDZ-binding motif inhibitors using GFP-fused transcriptional co-activator with PDZ-binding motif

Shunta Nagashima, Junichi Maruyama, Shodai Kawano, Hiroaki Iwasa, Kentaro Nakagawa, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Hiroshi Nishina, Yutaka Hata

CANCER SCIENCE, 107(6) 791-802, Jun, 2016 Peer-reviewed
Osmotic stress induces the phosphorylation of WNK4 Ser575 via the p38MAPK-MK pathway

Junichi Maruyama, Yumie Kobayashi, Tsuyoshi Umeda, Alain Vandewalle, Kohsuke Takeda, Hidenori Ichijo, Isao Naguro

SCIENTIFIC REPORTS, 6 18710, Jan, 2016 Peer-reviewedLead author
A cell-based screening for TAZ activators identifies ethacridine, a widely used antiseptic and abortifacient, as a compound that promotes dephosphorylation of TAZ and inhibits adipogenesis in C3H10T1/2 cells

Shodai Kawano, Junichi Maruyama, Shunta Nagashima, Kazutoshi Inami, Wenzhe Qiu, Hiroaki Iwasa, Kentaro Nakagawa, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Hiroshi Nishina …

JOURNAL OF BIOCHEMISTRY, 158(5) 413-423, Nov, 2015 Peer-reviewed

Professional Memberships

Research Projects

慢性炎症疾患へのがん併発現象におけるDCLK1の機能解析

研究助成がん領域【若手研究者】, 公益財団法人MSD生命科学財団, Apr, 2020 - Mar, 2022

丸山順一
特発性肺線維症への肺がん併発現象におけるDCLK1の機能解析

科学研究費補助金(若手研究), 文部科学省, 2018 - 2020

丸山順一
がん幹細胞性を決定するキナーゼDCLK1による発がん機構の解明

医学系研究助成, 武田科学振興財団, 2018

丸山順一
Analysis of tumor suppressors RASSF3 and RASSF6

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

Iwasa Hiroaki, Maruyama Junichi
Study on the tumor suppressor Hippo pathway and RASSF proteins

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

Hata Yutaka, Iwasa Hiroaki, Maruyama Junichi
Analysis of the molecular pathology of frequently-accompanied pulmonary cancer in fibrotic lung

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2014 - 2016

Maruyama Junichi

Social Activities

第3回土曜プログラム「がんの最先端研究」

Lecturer

埼玉栄中学校、株式会社トモノカイ, Aug 4, 2018 - Aug 4, 2018

Other

東京医科歯科大学オープンイノベーション機構プロモーター教員インタビュー「新旧の解析技術でHippoシグナル伝達経路のメカニズムを紐解く」

Oct, 2020 - Oct, 2020

https://tmdu-oi.jp/promoter/16%e3%80%80%e4%b8%b8%e5%b1%b1%e9%a0%86%e4%b8%80%e5%85%88%e7%94%9f

Profile Information

Research Interests

Research Areas

Research History

Education

Awards

Papers

Professional Memberships

Research Projects

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