2017年8月
Social isolation suppresses actin dynamics and synaptic plasticity through ADF/cofilin inactivation in the developing rat barrel cortex
SCIENTIFIC REPORTS
- 巻
- 7
- 号
- 1
- 開始ページ
- 8471
- 終了ページ
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/s41598-017-08849-3
- 出版者・発行元
- NATURE PUBLISHING GROUP
Exposure to a stressful environment early in life can cause psychiatric disorders by disrupting circuit formation. Actin plays central roles in regulating neuronal structure and protein trafficking. We have recently reported that neonatal isolation inactivated ADF/cofilin, the actin depolymerizing factor, resulted in a reduced actin dynamics at spines and an attenuation of synaptic alpha-amino-3-hydroxy-5-methyl-4- isoxazole propionic acid (AMPA) receptor delivery in the juvenile rat medial prefrontal cortex (mPFC), leading to altered social behaviours. Here, we investigated the impact of neonatal social isolation in the developing rat barrel cortex. Similar to the mPFC study, we detected an increase in stable actin fraction in spines and this resulted in a decreased synaptic AMPA receptor delivery. Thus, we conclude that early life social isolation affects multiple cortical areas with common molecular changes.
- リンク情報
-
- DOI
- https://doi.org/10.1038/s41598-017-08849-3
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/28814784
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000407677800025&DestApp=WOS_CPL
- URL
- https://www.nature.com/articles/s41598-017-08849-3
- ID情報
-
- DOI : 10.1038/s41598-017-08849-3
- ISSN : 2045-2322
- PubMed ID : 28814784
- Web of Science ID : WOS:000407677800025