Koike Shin

Profile Information

Affiliation: Meiji Pharmaceutical University

Degree: 博士（薬学）

Researcher number: 70751014
J-GLOBAL ID: 201801010198155849
researchmap Member ID: B000343935

Research Interests

Research Areas

Research History

Apr, 2021 - Present

Meiji Pharmaceutical University
Jul, 2014 - Mar, 2021

Meiji Pharmaceutical University
2011 - 2014

研究生, 国立精神・神経医療研究センター

Papers

Analysis and characterization of sulfane sulfur.

Shin Koike, Yuki Ogasawara

Analytical biochemistry, 687 115458-115458, Apr, 2024 Peer-reviewedLead author
Novel Fluorometric Assay of Antiglycation Activity Based on Methylglyoxal-Induced Protein Carbonylation

Shin Koike, Yuna Saito, Yuki Ogasawara

Antioxidants (Basel, Switzerland), 12(12) 2030, Nov, 2023 Peer-reviewedLead author
Methylglyoxal, which is also produced by the oxidation of glycerol, a moisturizing component, produce carbonylated collagen in the skin.

Shin Koike, Ko Sugiura, Yuki Ogasawara

International Maillard Reactions Society, 18(1), Jan, 2023 Lead author
Hyperoxidized Peroxiredoxin 2 Is a Possible Biomarker for the Diagnosis of Obstructive Sleep Apnea

Shin Koike, Haruka Sudo, Satori Turudome, Masako Ueyama, Yoshiaki Tanaka, Hiroshi Kimura, Yo-Ichi Ishida, Yuki Ogasawara

Antioxidants (Basel, Switzerland), 11(12) 2486, Dec, 2022 Peer-reviewedLead author
Exposure to Heated Tobacco Products Aerosol Causes Acute Stress Responses in the Lung of Mouse

Shin Koike, Kohei Sato, Marie Sawa, Yohei Inaba, Kenji Hattori, Kazuhiko Nakadate, Akira Ushiyama, Yuki Ogasawara

Antioxidants (Basel, Switzerland), 11(12) 2329, Nov, 2022 Peer-reviewedLead author
Plasma unconjugated bile acids as novel biomarker for schizophrenia.

Shin Koike, Yusuke Miyaji, Kazuhiro Suzuki, Mitsuhiro Miyashita, Masanari Itokawa, Makoto Arai, Yuki Ogasawara

Biochemical and biophysical research communications, 634 70-74, Oct 4, 2022 Peer-reviewedLead author
Inhibition of Amyloid-β Aggregation by p-Terphenyls from the Mushroom Polyozellus multiplex and Their Neuroprotective Effects

Shoko Nakabayashi, Ayaka Ishikura, Koji Fujihara, Shuntaro Hirabayashi, Shin Koike, Hiroaki Sasaki, Yuki Ogasawara, Kiyotaka Koyama, Kaoru Kinoshita

HETEROCYCLES, 104(11) 2025-2025, Sep, 2022 Peer-reviewed
Combined glyoxalase 1 dysfunction and vitamin B6 deficiency in a schizophrenia model system causes mitochondrial dysfunction in the prefrontal cortex

Kazuya Toriumi, Stefano Berto, Shin Koike, Noriyoshi Usui, Takashi Dan, Kazuhiro Suzuki, Mitsuhiro Miyashita, Yasue Horiuchi, Akane Yoshikawa, Mai Asakura …

Redox Biology, 45 102057-102057, Sep, 2021 Peer-reviewed
Carbonylation of skin collagen induced by reaction with methylglyoxal.

Ko Sugiura*, Shin Koike*, Toshihiro Suzuki, Yuki Ogasawara (* equal contribution)

Biochemical and biophysical research communications, 562 100-104, May 25, 2021 Peer-reviewed
Accumulation of Carbonyl Proteins in the Brain of Mouse Model for Methylglyoxal Detoxification Deficits. (Editor's Choice)

Shin Koike, Kazuya Toriumi, Sakura Kasahara, Yosuke Kibune, Yo-Ichi Ishida, Takashi Dan, Toshio Miyata, Makoto Arai, Yuki Ogasawara

Antioxidants (Basel, Switzerland), 10(4), Apr 8, 2021 Peer-reviewedLead author
Effects of osmolality on the expression of brain aquaporins in AQP11-null mice.

Shin Koike, Yasuko Tanaka, Yoshiyuki Morishita, Kenichi Ishibashi

Biochimie, Mar 29, 2021 Peer-reviewedLead author
Simultaneous determination of five bile acids as potential biomarkers for Alzheimer's disease in mouse brain and plasma.

Shin Koike, Yusuke Miyaji, Hinako Sano, Natsuki Aikawa, Masayuki Kai, Sakura Kasahara, Toshihiro Suzuki, Shoichi Nishimoto-Kusunose, Yuki Ogasawara

Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 37(8) 1165-1170, Jan 29, 2021 Peer-reviewedLead author
Oxidative Formation of Methylglyoxal in Glycerol Preparations during Storage.

Ko Sugiura, Shin Koike, Toshihiro Suzuki, Yuki Ogasawara

Biological & pharmaceutical bulletin, 43(5) 879-883, 2020 Peer-reviewed
Differential oxidation processes of peroxiredoxin 2 dependent on the reaction with several peroxides in human red blood cells.

Ishida YI, Ichinowatari Y, Nishimoto S, Koike S, Ishii K, Ogasawara Y

Biochemical and biophysical research communications, 518(4) 685-690, Oct, 2019 Peer-reviewed
Age-related alteration in the distribution of methylglyoxal and its metabolic enzymes in the mouse brain.

Koike S, Ando C, Usui Y, Kibune Y, Nishimoto S, Suzuki T, Ogasawara Y

Brain research bulletin, 144 164-170, Jan, 2019 Peer-reviewedLead author
Alternative pathway of H2S and polysulfides production from sulfurated catalytic-cysteine of reaction intermediates of 3-mercaptopyruvate sulfurtransferase

Noriyuki Nagahara, Shin Koike, Takashi Nirasawa, Hideo Kimura, Yuki Ogasawara

Biochemical and Biophysical Research Communications, 496(2) 648-653, Feb 5, 2018 Peer-reviewed
Analysis of endogenous H2S and H2Sn in mouse brain by high-performance liquid chromatography with fluorescence and tandem mass spectrometric detection

Shin Koike, Kumiko Kawamura, Yuka Kimura, Norihiro Shibuya, Hideo Kimura, Yuki Ogasawara

FREE RADICAL BIOLOGY AND MEDICINE, 113 355-362, Dec, 2017 Peer-reviewedLead author
Identification of an argpyrimidine-modified protein in human red blood cells from schizophrenic patients: A possible biomarker for, diseases involving carbonyl stress

Y. I. Ishida, T. Kayama, Y. Kibune, S. Nishimoto, S. Koike, T. Suzuki, Y. Horiuchi, M. Miyashita, M. Itokawa, M. Arai …

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 493(1) 573-577, Nov, 2017 Peer-reviewed
3-Mercaptopyruvate sulfurtransferase produces potential redox regulators cysteine- and glutathione-persulfide (Cys-SSH and GSSH) together with signaling molecules H2S2, H2S3 and H2S

Yuka Kimura, Shin Koike, Norihiro Shibuya, David Lefer, Yuki Ogasawara, Hideo Kimura

SCIENTIFIC REPORTS, 7(1) 10459, Sep, 2017 Peer-reviewed
Cysteine persulfides and polysulfides produced by exchange reactions with H2S protect SH-SY5Y cells from methylglyoxal-induced toxicity through Nrf2 activation

Shin Koike, Shoichi Nishimoto, Yuki Ogasawara

REDOX BIOLOGY, 12 530-539, Aug, 2017 Peer-reviewedLead author

Misc.

Simultaneous quantification of bile acids in the brain of mice by LC-MS/MS

宮地勇佑, 佐野日向子, 相川奈月, 甲斐雅之, 楠瀬翔一, 小池伸, 鈴木俊宏, 小笠原裕樹

日本薬学会年会要旨集(Web), 140th, 2020
カルボニルストレス性統合失調症患者iPS細胞由来グリア細胞の解析

堀内泰江, 石川充, 小池伸, 江越正敏, 小幡菜々子, 畠中真依, 許絲茵, 鳥海和也, 宮下光弘, 勝田奈那 …

統合失調症研究, 10(1), 2020
統合失調症患者赤血球中のアルグピリミジン化タンパク質の同定

木船陽介, 鹿山将, 小池伸, 鈴木俊宏, 石田洋一, 堀内泰江, 宮下光弘, 新井誠, 小笠原裕樹

日本薬学会年会要旨集, 138年会(3) 133-133, Mar, 2018
統合失調症患者赤血球中のアルグピリミジン化タンパク質の同定

木船陽介, 鹿山将, 小池伸, 鈴木俊宏, 石田洋一, 堀内泰江, 宮下光弘, 新井誠, 小笠原裕樹

日本薬学会年会要旨集, 138年会(3) 133-133, Mar, 2018
統合失調症患者血漿中におけるカルボニル化タンパク質およびAGEsの測定

鹿山将, 新井誠, 堀内泰江, 宮下光弘, 糸川昌成, 小池伸, 鈴木俊宏, 小笠原裕樹

日本薬学会年会要旨集, 136年会(3) 165-165, Mar, 2016
統合失調症患者における血液中低分子物質の測定

田中遼, 新井誠, 堀内泰江, 宮下光弘, 糸川昌成, 小池伸, 鈴木俊宏, 小笠原裕樹

日本薬学会年会要旨集, 136年会(3) 165-165, Mar, 2016
統合失調症患者における血液中低分子物質の測定

田中遼, 新井誠, 堀内泰江, 宮下光弘, 糸川昌成, 小池伸, 鈴木俊宏, 小笠原裕樹

日本薬学会年会要旨集, 136年会(3) 165-165, Mar, 2016
Polysulfide exerts protective effect against cytotoxicity through Nrf2 signaling in neuronal cells

Shin Koike, Yuki Ogasawara, Norihiro Shibuya, Kazuyuki Ishii, Hideo Kimura

NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 39 S39-S39, May, 2014
A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells

Norihiro Shibuya, Shin Koike, Makiko Tanaka, Mari Ishigami-Yuasa, Yuka Kimura, Yuki Ogasawara, Kiyoshi Fukui, Noriyuki Nagahara, Hideo Kimura

NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 39 S26-S26, May, 2014
Bound sulfur exerts protective effect against cytotoxicity in neuronal cells

Yuki Ogasawara, Shin Koike, Norihiro Shibuya, Kazuyuki Ishii, Hideo Kimura

NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 39 S13-S13, May, 2014
A novel pathway fot the production of hydrogen sulfide from D-cysteine in mammalian cells

Norihiro Shibuya, Shin Koike, Mari Yuasa-Ishigami, Makiko Tanaka, Yuka Kimura, Yuki Ogasawara, Kiyoshi Fukui, Noriyuki Nagahara, Hideo Kimura

JOURNAL OF PHARMACOLOGICAL SCIENCES, 124 123P-123P, 2014

Teaching Experience

Analytical Chemistry (Meiji Pharmaceutical University)

Professional Memberships

Research Projects

Sestrin2が制御する脳内カルボニル化タンパク質の分解と、その中枢疾患への関与

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2024 - Mar, 2027

小池伸
カルボニル化タンパク質の分解系に着目した統合失調症発症メカニズム解明の試み

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2021 - Mar, 2024

小池伸
神経伝達物質と反応するメチルグリオキサールの治療抵抗性統合失調症への関与

科学研究費補助金若手研究, 文部科学省, Apr, 2019 - Mar, 2021

小池伸
Nrf2活性化によるカルボニルストレスの抑制と、その治療抵抗性統合失調症への応用

科学研究費補助金若手(B), 文部科学省, 2017 - 2018

小池伸

Profile Information

Research Interests

Research Areas

Research History

Papers

Misc.

Teaching Experience

Professional Memberships

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