2001年11月
PACAP has a neurotrophic effect on cultured basal forebrain cholinergic neurons from adult rats
DEVELOPMENTAL BRAIN RESEARCH
- ,
- ,
- ,
- ,
- 巻
- 131
- 号
- 1-2
- 開始ページ
- 41
- 終了ページ
- 45
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/S0165-3806(01)00249-8
- 出版者・発行元
- ELSEVIER SCIENCE BV
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a member of the vasoactive intestinal polypeptide gene family (VIP) that was originally isolated from rat hypothalamus. The high affinity PACA-P receptor, PAC1, is expressed in the basal forebrain area of adult, as well as developing rat brain. Hippocampus, a targeting area of basal forebrain cholinergic neurons, contains PACAP Thus, hippocampal-derived PACAP may have an effect on basal forebrain cholinergic neurons. Indeed, we have reported that PACAP showed neurotrophic effects on these neurons in embryonic and early postnatal culture. Here we report that PACA-P has a neurotrophic effect on adult cholinergic neurons in culture. PACAP increases the number of choline acetyltransferase immunoreactive neurons about 2-fold. A similar effect was observed on treatment with cAMP analogue but not nerve growth factor. PACAP also improved the survival and neurite outgrowth of total neurons. These results indicate that PACAP acts as a neurotophic factor even on adult neurons in vitro. (C) 2001 Elsevier Science BY All rights reserved.
- リンク情報
- ID情報
-
- DOI : 10.1016/S0165-3806(01)00249-8
- ISSN : 0165-3806
- PubMed ID : 11718834
- Web of Science ID : WOS:000172517100005