1992年5月
MICROBIAL ASYMMETRIC HYDROLYSIS OF N-ACETYL-1-METHYL-3-PHENYLPROPYLAMINE TO OPTICALLY-ACTIVE 1-METHYL-3-PHENYLPROPYLAMINE
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- ,
- ,
- 巻
- 37
- 号
- 2
- 開始ページ
- 164
- 終了ページ
- 168
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1007/BF00178164
- 出版者・発行元
- SPRINGER VERLAG
The asymmetric hydrolysis of N-acetyl-1-methyl-3-phenylpropylamine (MPAc) by microorganisms was investigated. Various bacteria belonging to the genera Bacillus, Agrobacterium, Corynebacterium, Arthrobacter, Brevibacterium, Cellulomonas, Acinetobacter, Nocardia and Rhodococcus showed this hydrolysing activity and yielded (S)-1-methyl-3-phenylpropylamine (MPPA). Using washed cells of N. erythropolis IAM 1440, 15.1 mg/ml of (S)-MPPA was formed, with a 38.8% conversion yield and high stereoselectivity (97.9% enantiomeric excess), in an organic solvent-water diphase system. The same (S)-amine and (S)-1-phenylethylamine were also produced in good yields from the valeryl and isovaleryl derivatives of MPPA, and N-acetyl-1-phenylethylamine, respectively.
- リンク情報
- ID情報
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- DOI : 10.1007/BF00178164
- ISSN : 0175-7598
- PubMed ID : 10515797
- Web of Science ID : WOS:A1992HX60300005