2003年5月
Improvement of polydimethylsiloxane guide tube for nerve regeneration treatment by carbon negative-ion implantation
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS
- ,
- ,
- ,
- ,
- ,
- ,
- 巻
- 206
- 号
- 開始ページ
- 507
- 終了ページ
- 511
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/S0168-583X(03)00809-7
- 出版者・発行元
- ELSEVIER SCIENCE BV
Modification of polydimethylsiloxane (PDMS) rubber by negative ion-implantation was investigated for improvement of nerve regeneration property. The PDMS rubber surface was found to have more hydrophilic property after carbon negative-ion implantation than before. At the conditions of 10 keV and 3.0 x 10(15) ions/cm(2), the contact angle decreased to 83degrees from 100degrees. The reason of the hydrophilic modification is due to hydrophilic functional groups such as hydroxyl formed at the surface by radiation effect of ion implantation. The in vivo regeneration test of rat sciatic nerve was performed by using 18-mm-long PDMS rubber tubes with inner diameter of 2 mm, the inner surface of which was implanted with carbon negative ions at the above conditions. At 24 weeks after the clinical surgery, the sciatic nerve was regenerated through the tube between the proximal and distal nerve stumps. (C) 2003 Elsevier Science B.V. All rights reserved.
- リンク情報
- ID情報
-
- DOI : 10.1016/S0168-583X(03)00809-7
- ISSN : 0168-583X
- Web of Science ID : WOS:000183690500111