2013年9月23日
Dearomatizing conjugate addition to quinolinyl amidines for the synthesis of dehaloperophoramidine through tandem arylation and allylation
Angewandte Chemie - International Edition
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- 巻
- 52
- 号
- 39
- 開始ページ
- 10204
- 終了ページ
- 10207
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/anie.201305581
Dehaloperophoramidine, the dehalogenated analogue of the marine hexacyclic alkaloid perophoramidine was synthesized. The intramolecular nucleophilic dearomatizing arylation of aminoquinoline initiated by a lithium-iodine exchange and the subsequent direct allylation of the resultant azaenolate afforded a pentacyclic bisamidine compound bearing two contiguous all-carbon quaternary centers in good yield with excellent diastereoselectivity. Copyright © 2013 WILEY-VCH Verlag GmbH &
Co. KGaA, Weinheim.
Co. KGaA, Weinheim.
- リンク情報
- ID情報
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- DOI : 10.1002/anie.201305581
- ISSN : 1433-7851
- ISSN : 1521-3773
- J-Global ID : 201302268822190860
- PubMed ID : 23934788
- SCOPUS ID : 84884863711