論文

2021年5月

Continuum modeling for neuronal lamination during cerebral morphogenesis considering cell migration and tissue growth

COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
  • Hironori Takeda
  • ,
  • Yoshitaka Kameo
  • ,
  • Taiji Adachi

24
7
開始ページ
799
終了ページ
805
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1080/10255842.2020.1852554
出版者・発行元
TAYLOR & FRANCIS LTD

For neuronal lamination during cerebral morphogenesis, later-born neurons must migrate through already-accumulated neurons. This neuronal migration is biochemically regulated by signaling molecules and mechanically affected by tissue deformation. To understand the neuronal lamination mechanisms, we constructed a continuum model of neuronal migration in a growing deformable tissue. We performed numerical analyses considering the migration promoted by signaling molecules and the tissue growth induced by neuron accumulation. The results suggest that the promoted migration and the space ensured by tissue growth are essential for neuronal lamination. The proposed model can describe the coupling of mechanical and biochemical mechanisms for neuronal lamination.

リンク情報
DOI
https://doi.org/10.1080/10255842.2020.1852554
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000597003800001&DestApp=WOS_CPL
ID情報
  • DOI : 10.1080/10255842.2020.1852554
  • ISSN : 1025-5842
  • eISSN : 1476-8259
  • Web of Science ID : WOS:000597003800001

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