長田聡史 (Satoshi OSADA) - マイポータル

基本情報

所属: 佐賀大学佐賀大学理工学部理工学科准教授

学位: 博士(理学)(九州大学)

J-GLOBAL ID: 200901082224654353
researchmap会員ID: 1000205732

外部リンク: http://www.chem.saga-u.ac.jp/staffs.html

研究キーワード

研究分野

経歴

1999年 - 2000年

スタンフォード大学文部省在外研究員
1999年 - 2000年

Stanford University, Visiting Scholar

学歴

受賞

2007年

有機合成化学協会九州山口支部奨励賞

論文

105

Peptide Deformylase Processable Triazole-containing Formyl Peptide Mimetics

2016年3月査読有り
Effects of E/Z configuration of fluoroalkene-containing HDAC inhibitors on selectivity for HDAC isoforms

42(8) 833-835 2013年8月査読有り
Structure-activity relationship of a transmembrane peptide derived from formyl peptide receptor 1

221-224 2013年4月査読有り
Ion channel formation by charged cyclic peptides

195-198 2013年4月査読有り
A formyl peptide substituted with a conformationally constrained phenylalanine residue evokes a selective immune response in human neutrophils

21(3) 668-675 2013年1月査読有り
Formation of ion-selective channel using cyclic tetrapeptides

20(1) 42-46 2012年1月査読有り
Significance of Intermolecular Hydrogen-Bonding to Form Ion Channel by the Cyclic Tetrapeptide cyclo(D-Ala-Dap)2

156-157 2011年7月査読有り
Contribution of hydrophobic side-chain in cyclic tetrapeptide forming ion channel

130 2011年3月査読有り
Peptaibol Derived Helix-Kink Motif Facilitates Channel Forming of the Artificial α-Aminoisobutyric Acid Rich Helices

16 277-282 2010年9月査読有り
Trans-bilayer ion conduction by proline containing cyclic hexapeptides and effects of amino acid substitutions on ion conducting properties

83 638-688 2010年5月査読有り
Receptor Subtype Selectivity of Dimeric Chemotactic Antagonists

199-202 2010年4月査読有り
Amino Acid Sequence Dependence of Ion Channel Activity by Cyclic Tetrapeptides

195-198 2010年4月査読有り
Methionine Analogs with the γ-Carbon and Sulfur Atoms Replaced by a Fluoroalkene Unit

123-126 2010年4月査読有り
Fluoroalkene Modification of Mercaptoacetamide-based Histone Deacetylase Inhibitors

18(2) 605-611 2010年1月査読有り
Synthesis and Biological Activity of Cyclic Peptide, Hymenamide Analogs

2009 323-324 2009年3月査読有り
Synthesis and Biological Activity of Transmembrane Peptides Derived from FPR Family Receptors

2008 331-332 2009年3月査読有り
Synthesis and Biological Activity of Alamethicin Analogs Enhanced by Electrostatic Interaction

IMAMURA Satoko, TAIRA Junichi, SUGA Torao, OSADA Satoshi, KODAMA Hiroaki

Peptide science : proceedings of the ... Japanese Peptide Symposium 2008 245-248 2009年3月査読有り
Synthesis and Priming Activities of Cyclic Peptides, Hymenamides

ONAI Mika, SUGIYAMA Daisuke, OSADA Satoshi, FUJITA Ichiro, HAMASAKI Yuhei, KODAMA Hiroaki

Peptide science : proceedings of the ... Japanese Peptide Symposium 2008 239-242 2009年3月査読有り
Insight into Methionine Side-Chain Recognition by the FPR Utilizing Sulfur Mimitics

249-252 2009年3月査読有り
Synthesis and Biological Activity of Dimeric Chemotactic Peptide Antagonist

SUGIYAMA Daisuke, HIRAKAWA Yuki, OSADA Satoshi, FUJITA Ichiro, HAMASAKI Yuhei, KODAMA Hiroaki

Peptide science : proceedings of the ... Japanese Peptide Symposium 2008 253-256 2009年3月査読有り

もっとみる

MISC

Promotion of cell adhesion by low-molecular-weight hydrogel by Lys based amphiphile

Torao Suga, Satoshi Osada, Takayuki Narita, Yushi Oishi, Hiroaki Kodama

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 47 345-350 2015年2月
Anti-tumor activities of Au(I) complexed with bisphosphines in HL-60 cells

Ryo Hayashi, Kazuhiro Nakatsui, Daisuke Sugiyama, Toshiki Kitajima, Nobuhiko Oohara, Masashi Sugiya, Satoshi Osada, Hiroaki Kodama

JOURNAL OF INORGANIC BIOCHEMISTRY 137 109-114 2014年8月
Development of potent antagonists for formyl peptide receptor 1 based on Boc-Phe-D-Leu-Phe-D-Leu-Phe-OH

Ryo Hayashi, Toshiki Kitajima, Hikaru Mizuguchi, Miki Fujimoto, Aya Yamaguchi, Shuichiro Koga, Yuya Koga, Satoshi Osada, Hiroaki Kodama

BIOORGANIC & MEDICINAL CHEMISTRY 22(15) 3824-3828 2014年8月
Effects of E/Z Configuration of Fluoroalkene-containing HDAC Inhibitors on Selectivity for HDAC Isoforms

Yoshiro Chuman, Mariko Ueyama, Satoshi Sano, Fei Wu, Yuhei Kiyota, Takayoshi Higashi, Satoshi Osada, Kazuyasu Sakaguchi

CHEMISTRY LETTERS 42(8) 833-835 2013年8月
A formyl peptide substituted with a conformationally constrained phenylalanine residue evokes a selective immune response in human neutrophils

Ryo Hayashi, Masaya Miyazaki, Satoshi Osada, Hiroshi Kawasaki, Ichiro Fujita, Yuhei Hamasaki, Hiroaki Kodama

Bioorganic and Medicinal Chemistry 21(3) 668-675 2013年2月1日
The cell adhesion and proliferation activities of a peptide derived from human tenascin-C are dependent on two Ile residues

Ryo Hayashi, Shogo Miura, Yohei Saito, Satoshi Osada, Takuya Iyoda, Fumio Fukai, Hiroaki Kodama

BIOORGANIC & MEDICINAL CHEMISTRY 20(15) 4608-4613 2012年8月
Formation of ion-selective channel using cyclic tetrapeptides

Torao Suga, Satoshi Osada, Hiroaki Kodama

BIOORGANIC & MEDICINAL CHEMISTRY 20(1) 42-46 2012年1月
Peptaibol Derived HelixãKink Motif Facilitates Channel Forming of the Artificial α-Aminoisobutyric Acid Rich Helices

Junichi Taira, Junichi Taira, Mitsukuni Shibue, Satoshi Osada, Hiroaki Kodama

International Journal of Peptide Research and Therapeutics 16(4) 277-282 2010年12月
Trans-Bilayer Ion Conduction by Proline Containing Cyclic Hexapeptides and Effects of Amino Acid Substitutions on Ion Conducting Properties

Junichi Taira, Satoshi Osada, Ryo Hayashi, Toshihisa Ueda, Masoud Jelokhani-Niaraki, Haruhiko Aoyagi, Hiroaki Kodama

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN 83(6) 683-688 2010年6月
Fluoroalkene modification of mercaptoacetamide-based histone deacetylase inhibitors

Satoshi Osada, Satoshi Sano, Mariko Ueyama, Yoshiro Chuman, Hiroaki Kodama, Kazuyasu Sakaguchi

BIOORGANIC & MEDICINAL CHEMISTRY 18(2) 605-611 2010年1月
Conformational Effects of Cyclic Hexapeptides for Ion Channel Properties

Junichi Taira, Satoko Imamura, Satoshi Osada, Masoud Jelokhani-Niaraki, Tsuguhisa Ehara, Hiroaki Kodama

PEPTIDES FOR YOUTH 611 321-322 2009年
Ion Channel Formation of Dimeric Peptide Enhanced by Electrostatic Inter-Helical Interactions

Junichi Taira, Satoshi Osada, Masoud Jelokhani-Niaraki, Tsuguhisa Ehara, Hiroaki Kodama

PEPTIDES FOR YOUTH 611 337-338 2009年
Synthesis and Biological Activities of Cyclic Peptide, Hymenamide Analogs

Yasuhiro Shiki, Mika Onai, Daisuke Sugiyama, Satoshi Osada, Ichiro Fujita, Hiroaki Kodama

PEPTIDES FOR YOUTH 611 323-324 2009年
Synthesis and Biological Activity of Transmembrane Peptides Derived from FPR Family Receptors

Daisuke Sugiyama, Ryo Hayashi, Satoshi Osada, Yuhei Hamasaki, Ichiro Fujita, Hiroaki Kodama

PEPTIDES FOR YOUTH 611 331-332 2009年
Ion-channel formation assisted by electrostatic interhelical interactions in covalently dimerized amphiphilic helical peptides

Junichi Taira, Masoud Jelokhani-Niaraki, Satoshi Osada, Fumio Kato, Hiroaki Kodama

BIOCHEMISTRY 47(12) 3705-3714 2008年3月
フッ素化でジグザグ分子をつくり分け − 部分フッ素化による配座チューニング

長田聰史

化学 63(11) 61-62 2008年
Superoxide production in human neutrophils is enhanced by treatment with transmembrane peptides derived from human formyl peptide receptor

Ryo Hayashi, Satoshi Osada, Masahiro Yoshiki, Daisuke Sugiyama, Ichiro Fujita, Yuhei Hamasaki, Hiroaki Kodama

JOURNAL OF BIOCHEMISTRY 139(6) 981-988 2006年6月
Facile synthesis of (S)-5,5-difluoronorleucine and its incorporation in biologically active peptides as an methionine mimetic

S Osada, T Ishimaru, H Kawasaki, H Kodama

HETEROCYCLES 67(1) 421-431 2006年1月
Effect of α,α-dialkyl amino acids on the protease resistance of peptides

Hiroshi Yamaguchi, Hiroaki Kodama, Satoshi Osada, Fumio Kato, Masood Jelokhani-Niaraki, Michio Kondo

Bioscience, Biotechnology and Biochemistry 67(10) 2269-2272 2003年10月
新機能創出をめざした新規アミノ酸・ペプチドの化学合成

長田聰史, 兒玉浩明

生物工学会誌 81(9) 382-385 2003年

もっとみる

書籍等出版物

Synthesis and Solution Structures of Cyclic Hexapeptides Cyclo(Pro-Leu-Xxx)（共著）

Peptides The Wave of the Future 2002年
Synthesis and Properties of Transmembrane Domains of Uncoupling Protein, UCP-2（共著）

Peptides Science 2001 2002年
Photoaffinity Labeling of Formylpeptide Receptors by fMLP Analogs （共著）

Peptides Science 2001 2002年
Synthesis and Conformational Studies of Cyclic Peptides Containing the C-terminal Tripeptide Sequence of Oxytocin (共著)

Peptide Science 1998 1999年
Effect of enviroment on the stability of helical Aib-model peptides (共著)

Peptides Science ﾐ Present and Future 1999年
Receptor Specificity of [2,3-Cyclopropane Amino Acids]-fMLP Analogs (共著)

Peptides- Frontiers of Peptide Science 1999年
Activation of Human Neutrophils by fMLP Analogs Containing 2,3-Cyclopropane Amino Acid(共著)

Peptide Chemistry 1996 1997年

所属学協会

共同研究・競争的資金等の研究課題

ミメティックプローブによるN末端メチオニン認識機構の解明と生体防御への応用

科学研究費補助金 2007年 - 2008年
含フッ素アミノ酸の合成と生理活性ペプチドへの導入
Synthesis of unnatural amino acids.
Synthesis of fluorine-containing amino acids and their peptides