2021年5月
Prolonged high-intensity exercise induces fluctuating immune responses to herpes simplex virus infection via glucocorticoids
Journal of Allergy and Clinical Immunology
- 巻
- 148
- 号
- 6
- 開始ページ
- 1575
- 終了ページ
- 1588
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.jaci.2021.04.028
- 出版者・発行元
- Elsevier BV
BACKGROUND: Epidemiologic studies have yielded conflicting results regarding the influence of a single bout of prolonged high-intensity exercise on viral infection. OBJECTIVE: We sought to learn whether prolonged high-intensity exercise either exacerbates or ameliorates herpes simplex virus type 2 (HSV-2) infection according to the interval between virus exposure and exercise. METHODS: Mice were intravaginally infected with HSV-2 and exposed to run on the treadmill. RESULTS: Prolonged high-intensity exercise 17 hours after infection impaired the clearance of HSV-2, while exercise 8 hours after infection enhanced the clearance of HSV-2. These impaired or enhanced immune responses were related to a transient decrease or increase in the number of blood-circulating plasmacytoid dendritic cells. Exercise-induced glucocorticoids transiently decreased the number of circulating plasmacytoid dendritic cells by facilitating their homing to the bone marrow via the CXCL12-CXCR4 axis, which led to their subsequent increase in the blood. CONCLUSION: A single bout of prolonged high-intensity exercise can be either deleterious or beneficial to antiviral immunity.
- リンク情報
- ID情報
-
- DOI : 10.1016/j.jaci.2021.04.028
- ISSN : 0091-6749
- PubMed ID : 33965431