2016年7月
Organocatalytic Enantioselective Aza-Friedel-Crafts Reaction of Cyclic Ketimines with Pyrroles using Imidazolinephosphoric Acid Catalysts
CHEMISTRY-A EUROPEAN JOURNAL
- ,
- ,
- 巻
- 22
- 号
- 28
- 開始ページ
- 9478
- 終了ページ
- 9482
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/chem.201601573
- 出版者・発行元
- WILEY-V C H VERLAG GMBH
Organocatalytic enantioselective aza-Friedel-Crafts reactions of cyclic ketimines with pyrroles or indoles were catalyzed by imidazoline/phosphoric acid catalysts. The reaction was applied to various 3H-indol-3-ones to afford products in excellent yields and enantioselectivities. The chiral catalysts can be recovered by a single separation step using column chromatography and are reusable without further purification. Based on the experimental investigations, a possible transition state has been proposed to explain the origin of the asymmetric induction.
- リンク情報
- ID情報
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- DOI : 10.1002/chem.201601573
- ISSN : 0947-6539
- eISSN : 1521-3765
- Web of Science ID : WOS:000380271400003