2012年12月
Pathomechanism of atopic dermatitis in the perspective of T cell subsets and skin barrier functions - "Which comes first, the chicken or the egg?"
DERMATOLOGICA SINICA
- 巻
- 30
- 号
- 4
- 開始ページ
- 142
- 終了ページ
- 146
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/j.dsi.2012.07.003
- 出版者・発行元
- ELSEVIER TAIWAN
Atopic dermatitis (AD) is a common skin condition that is characterized by a complex, heterogeneous pathogenesis. The possible candidates for its pathogenesis include skin barrier abnormality and allergy/immunology aspects. It has long been asked, "Which comes first, the barrier dysfunction or the allergy/immunology abnormality?" Recently, direct evidence of a link between the incidence of AD and loss-of-function mutations in the gene encoding Filaggrin has been discovered. This finding suggests that barrier dysfunction is a primary cause of AD. It has also been widely recognized that T cells play an important role in the development of AD in the perspective of the Th1/Th2 paradigm. Recently, however, new T cell subsets, Th17, T22, and regulatory T cells have been identified. In this review, we will update the roles of T cell subsets in AD and ascertain how skin barrier abnormality and allergy/immunology interact in a highly interdisciplinary manner. Copyright (c) 2012, Taiwanese Dermatological Association. Published by Elsevier Taiwan LLC. All rights reserved.
- リンク情報
- ID情報
-
- DOI : 10.1016/j.dsi.2012.07.003
- ISSN : 1027-8117
- Web of Science ID : WOS:000313090300005