長山人三 (Hitomi Nagayama) - マイポータル - researchmap

基本情報

学位: 博士（医学）(2002年2月東京大学)
医学士(1990年3月自治医科大学)

連絡先: zephyrist1113gmail.com
研究者番号: 50301148
ORCID ID: https://orcid.org/0000-0002-9674-659X
J-GLOBAL ID: 200901052947120644
researchmap会員ID: 5000074980

1998年日本初の成人臍帯血移植に成功
1999年致死量中性子線被曝患者に対して世界で初めて臍帯血移植を施行
1999年第Ⅳ期悪性黒色腫患者に対する日本初の樹状細胞を用いた腫瘍特異的免疫療法臨床第Ⅰ相治験を終了（東京大学医科学研究所・国立がんセンター・山梨医科大学・信州大学・慶應義塾大学先端医科学研究所の共同研究）
2010年進行期膵癌患者に対する癌ペプチドワクチンを用いた臨床第Ⅰ/Ⅱ相試験を終了

研究キーワード

4

研究分野

1

ライフサイエンス / 血液、腫瘍内科学 /

経歴

2

2021年4月 - 2022年7月

熊本大学, 国際先端医学研究機構, 客員教授 (博士（医学）)
2018年4月 - 2021年3月

帝京大学, ちば総合医療センター, 病院教授

論文

46

Thyrotoxicosis after unrelated cord blood transplantation for adults.

Takaaki Konuma, Akira Tomonari, Jun Ooi, Hitomi Nagayama, Toshiro Kawakita, Seiko Kato, Masamichi Isobe, Maki Monna-Oiwa, Arinobu Tojo, Yasuhito Nannya …

Annals of hematology 2022年12月17日査読有り
Long-term outcomes following the addition of granulocyte colony-stimulating factor-combined high-dose cytarabine to total body irradiation and cyclophosphamide conditioning in single-unit cord blood transplantation for myeloid malignancies

Takaaki Konuma, Jun Ooi, Hitomi Nagayama, Akira Tomonari, Nobuhiro Tsukada, Seiko Kato, Toshiro Kawakita, Masamichi Isobe, Maki Monna-Oiwa, Arinobu Tojo …

Annals of Hematology 2021年9月30日査読有り
Cytokine Profile in Sweet's Syndrome under the Treatment of Pulmonary Toxoplasmosis Complicated with Myelodysplastic Syndrome.

Matsuzawa Y, Adachi E, Takahashi A, Sato H, Lim LA, Komatsu T, Koibuchi T, Nagamura-Inoue T, Tojo A, Nagayama H …

Internal medicine (Tokyo, Japan) 58(14) 2079-2083 2019年7月査読有り
Gastrointestinal bleeding during anti-angiogenic peptide vaccination in combination with gemcitabine for advanced pancreatic cancer

Hitomi Nagayama, Kazufumi Matsumoto, Naoyuki Isoo, Hideki Ohno, Naoyuki Takahashi, Takashi Nakaoka, Masaru Shinozaki, Makoto Watanabe, Yusuke Inoue, Fumitaka Nagamura …

Clinical Journal of Gastroenterology 3(6) 307-317 2010年12月査読有り
Simple Triage and Rapid Decontamination of Mass Casualties with Colored Clothes Pegs (STARDOM-CCP) System against Chemical Releases

Tetsu Okumura, Hisayoshi Kondo, Hitomi Nagayama, Toshiro Makino, Toshiharu Yoshioka, Yasuhiro Yamamoto

PREHOSPITAL AND DISASTER MEDICINE 22(3) 233-236 2007年6月査読有り
Early-onset thyrotoxicosis after unrelated cord blood transplantation for acute myelogenous leukemia

T Konuma, A Tomonari, S Takahashi, J Ooi, N Tsukada, T Yamada, H Sato, H Nagayama, T Iseki, A Tojo …

INTERNATIONAL JOURNAL OF HEMATOLOGY 83(4) 348-350 2006年5月査読有り
Ex vivo manipulation of umbilical cord blood-derived hematopoietic stem/progenitor cells with recombinant human stem cell factor can up-regulate levels of homing-essential molecules to increase their transmigratory potential

YZ Zheng, N Watanabe, T Nagamura-Inoue, K Igura, H Nagayama, A Tojo, R Tanosaki, Y Takaue, S Okamoto, TA Takahashi

EXPERIMENTAL HEMATOLOGY 31(12) 1237-1246 2003年12月査読有り
Results of a phase I clinical study using autologous tumour lysate-pulsed monocyte-derived mature dendritic cell vaccinations for stage IV malignant melanoma patients combined with low dose interleukin-2

H Nagayama, K Sato, M Morishita, K Uchimaru, N Oyaizu, T Inazawa, J Yamasaki, M Enomoto, T Nakaoka, T Nakamura …

MELANOMA RESEARCH 13(5) 521-530 2003年10月査読有り
Granulocyte transfusion as a treatment for enterococcal meningoencephalitis after allogeneic bone marrow transplantation from an unrelated donor

Y Tsukada, H Nagayama, T Mori, T Shimizu, N Sato, N Takayama, A Ishida, M Handa, Y Ikeda, S Okamoto

BONE MARROW TRANSPLANTATION 31(1) 69-72 2003年1月査読有り
Granisetron plus dexamethasone versus granisetron alone in the prevention of vomiting induced by conditioning for stem cell transplantation: A prospective randomized study

S Matsuoka, S Okamoto, R Watanabe, T Mori, H Nagayama, Y Hamano, K Yokoyama, N Takayama, Y Ikeda

INTERNATIONAL JOURNAL OF HEMATOLOGY 77(1) 86-90 2003年1月査読有り
Analysis of human TIE2 function on hematopoietic stem cells in umbilical cord blood

H Yuasa, N Takakura, T Shimomura, S Suenobu, T Yamada, H Nagayama, Y Oike, T Suda

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 298(5) 731-737 2002年11月査読有り
Using related donors other than genotypically HLA-matched siblings in allogeneic hematopoietic stem cell transplantation for hematologic disease: A single institution experience in Japan

A Tomonari, T Iseki, J Ooi, S Takahashi, K Ishii, T Takahashi, M Shindo, F Nagamura, K Uchimaru, H Nagayama …

INTERNATIONAL JOURNAL OF HEMATOLOGY 76(4) 354-359 2002年11月査読有り
Severe immune dysfunction after lethal neutron irradiation in a JCO nuclear facility accident victim

H Nagayama, J Ooi, A Tomonari, T Iseki, A Tojo, K Tani, TA Takahashi, N Yamashita, S Asano

INTERNATIONAL JOURNAL OF HEMATOLOGY 76(2) 157-164 2002年8月査読有り
A clinical comparison of unrelated cord blood transplantation and unrelated bone marrow transplantation for adult patients with acute leukaemia in complete remission

J Ooi, T Iseki, S Takahashi, A Tomonari, H Nagayama, K Ishii, K Ito, H Sato, T Takahashi, M Shindo …

BRITISH JOURNAL OF HAEMATOLOGY 118(1) 140-143 2002年7月査読有り
Incidence of cytomegalovirus (CMV) infection in allogeneic hematopoietic stem cell recipients at low risk of CMV infection

T Mori, S Okamoto, R Watanabe, R Yamazaki, Y Tsukada, H Nagayama, A Ishida, Y Ikeda

BONE MARROW TRANSPLANTATION 29(12) 1005-1006 2002年6月査読有り
Long-term follow-up of allogeneic bone marrow transplantation after reduced-intensity conditioning in patients with chronic myelogenous leukemia in the chronic phase

S Okamoto, R Watanabe, S Takahashi, T Mori, T Izeki, H Nagayama, A Ishida, N Takayama, K Yokoyama, A Tojo …

INTERNATIONAL JOURNAL OF HEMATOLOGY 75(5) 493-498 2002年6月査読有り
Acquired pulmonary alveolar proteinosis after umbilical cord blood transplantation for acute myeloid leukemia

A Tomonari, N Shirafuji, T Iseki, J Ooi, H Nagayama, A Masunaga, A Tojo, K Tani, S Asano

AMERICAN JOURNAL OF HEMATOLOGY 70(2) 154-157 2002年6月査読有り
Second allogeneic hematopoietic stem cell transplantation for leukemia relapse after first allogeneic transplantation: Outcome of 16 patients in a single institution

A Tomonari, T Iseki, J Ooi, H Nagayama, H Sato, T Takahashi, K Ito, F Nagamura, K Uchimaru, S Takahashi …

INTERNATIONAL JOURNAL OF HEMATOLOGY 75(3) 318-323 2002年4月査読有り
Transient hematopoietic stem cell rescue using umbilical cord blood for a lethally irradiated nuclear accident victim

H Nagayama, K Misawa, H Tanaka, J Ooi, T Iseki, A Tojo, K Tani, Y Yamada, H Kodo, TA Takahashi …

BONE MARROW TRANSPLANTATION 29(3) 197-204 2002年2月査読有り
Dose-adjusted preemptive therapy for cytomegalovirus disease based on real-time polymerase chain reaction after allogeneic hematopoietic stem cell transplantation

T. Mori, S. Okamoto, R. Watanabe, T. Yajima, Y. Iwao, R. Yamazaki, T. Nakazato, N. Sato, T. Iguchi, H. Nagayama …

Bone Marrow Transplantation 29(9) 777-782 2002年査読有り

もっとみる

MISC

30

Factors influent on incidence and speed of engraftment of unrelated cord blood transplantation in 46 Japanese adult patients with units shipped from Tokyo Cord Blood Bank: Influence of the dose of CD 34+ cell and colony forming cells.

T Nagamura-Inour, M Shioya, M Sugo, Y Cui, A Takahashi, K Takada, S Tomita, U Iwamoto, Y Tokushima, A Taguchi …

BLOOD 100(11) 466B-467B 2002年11月
Late-onset non-infectious pulmonary complications after allogeneic stem cell transplantation (SCT)

R Watanabe, S Okamoto, T Mori, H Nishida, Y Tsukada, N Sato, H Nagayama, N Takayama, Y Ikeda

BONE MARROW TRANSPLANTATION 29 S178-S178 2002年3月
Risk factors of acute graft-versus-host disease (AGVHD) after allogeneic bone marrow transplantation using an matched unrelated donor (MUD) and prophylaxis with taclorimus (FK506) and methotrexate (MTX)

T Iguchi, S Okamoto, T Mori, R Watanabe, N Sato, H Nagayama, N Takayama, Y Ikeda

BONE MARROW TRANSPLANTATION 29 S172-S173 2002年3月
Long-term follow-up of allogeneic bone marrow transplantation after reduced-intensity conditioning in patients with chronic myelogenous leukemia in the chronic phase

Y Tsukada, S Okamoto, T Mori, R Watanabe, T Iguchi, R Yamazaki, N Sato, H Nagayama, N Takayama, Y Ikeda

BONE MARROW TRANSPLANTATION 29 S162-S162 2002年3月
Dendritic cell therapy for stage IV melanoma: Two cases of multiple tumor necrosis.

M Morishita, N Oyaizu, K Uchimaru, K Sato, H Nagayama, T Inazawa, T Nakaoka, E Akagawa, S Shimada, Y Kawakami …

BLOOD 98(11) 18A-19A 2001年11月
Lower expressions of adhesion molecules, CD49e, CD49f and CD54, and chemokine, receptor CXCR-4 on CD34(high) cells in umbilical cord blood compared with those in mobilized peripheral blood and bone marrow.

YZ Zheng, N Watanabe, T Nagamura-Inoue, H Nagayama, S Asano, Y Takaue, S Okamoto, TA Takahashi

BLOOD 98(11) 147B-148B 2001年11月
非血縁者間臍帯血移植

長山人三, 高橋恒夫

日本輸血学会雑誌 47(3) 518-523 2001年7月1日
New York Blood center protocolに準じたさい帯血保存法の検討東京さい帯血バンク

長村登紀子, 長山人三, 高橋恒夫

日本輸血学会雑誌 47(2) 284 2001年4月1日
臨床成人に対する臍帯血移植の現状 (特集細胞療法--基礎と臨床)

井関徹, 大井淳, 長山人三

現代医療 32(11) 2665-2671 2000年11月
Total body irradiation (TBI) and high-dose etoposide (VP-16) followed by allogeneic bone marrow transplantation (BMT) in adults with acute lymphoblastic leukemia (ALL): Long-term follow-up.

J Ooi, T Iseki, H Nagayama, A Tomonari, M Sawada, A Tojo, K Tani, S Asano

BLOOD 96(11) 356B-357B 2000年11月
Phase I clinical study of autologous monocyte-derived dendritic cell therapy for stage IV malignant melanoma patients in Japan.

H Nagayama, K Sato, M Enomoto, K Uchimaru, T Saida, S Shimada, Y Kawakami, S Asano, N Yamashita, TA Takahashi

BLOOD 96(11) 323B-323B 2000年11月
臍帯血細胞の凍結保存:造血幹細胞移植と細胞治療への臨床応用

長山人三, 高橋恒夫

低温生物工学会誌 = Cryobiology and cryotechnology 46(1) 6-7 2000年8月26日
同種骨髄移植時にみられる急性GvHDの重症度と可溶性HLAクラスI抗原の相関

前川平, 鈴木しのぶ, 井関徹, 長山人三, 中畑龍俊, 浅野茂隆

日本輸血学会雑誌 46(2) 206-206 2000年4月
Clinical results of transplantation of placental/umbilical cord blood processed by hydroxyethyl starch method: Importance of cell washing before transplantation.

S Wada, M Sugo, K Ichihara, K Katayama, N Sasayama, H Nagayama, Y Xu, S Asano, TA Takahashi

BLOOD 94(10) 343B-343B 1999年11月
CC chemokine receptor, CCR-1 and CCR-3, potentially regulate the development of cord blood CD34(+) hematopoietic progenitor cell-derived dendritic cells.

K Sato, H Kawasaki, H Nagayama, M Enomoto, C Morimoto, TA Takahashi

BLOOD 94(10) 211A-211A 1999年11月
Reciprocal control of antigen-presenting cell function of human peripheral blood monocyte-derived CD4(+) dendritic cells.

K Sato, H Nagayama, M Enomoto, K Tadokoro, T Juji, TA Takahashi

BLOOD 94(10) 44B-44B 1999年11月
Unrelated HLA mismatched cord blood transplantation in patients with high risk acute leukemia: A single institution experience.

T Iseki, J Ooi, H Nagayama, N Shirafuji, R Tanaka, J Manabe, A Tojo, K Tsuji, K Tani, S Asano

BLOOD 94(10) 391B-391B 1999年11月
IL-12 responsiveness and expression of IL-12 receptor beta 1 in human peripheral blood monocyte-derived dendritic cells.

H Nagayama, K Sato, H Kawasaki, M Enomoto, C Morimoto, K Tadokoro, T Juji, S Asano, TA Takahashi

BLOOD 94(10) 170B-170B 1999年11月
Molecular basis of downmodulation of chemotaxis via CC chemokine receptors during maturation of human peripheral blood monocyte-derived dendritic cells.

K Sato, H Kawasaki, H Nagayama, M Enomoto, C Morimoto, K Tadokoro, T Juji, TA Takahashi

BLOOD 94(10) 44B-44B 1999年11月
Expression of 4-1BB and OX40 on T cells after allogeneic stem cell transplantation does not correlate with incidence and severity of acute graft-versus-host disease.

J Ooi, A Tojo, T Iseki, N Shirafuji, H Nagayama, K Tani, S Asano

BLOOD 94(10) 371B-371B 1999年11月

もっとみる

共同研究・競争的資金等の研究課題

1

臍帯血由来樹状細胞とCMV特異的ペプチドを用いたCMVワクチンの開発

日本学術振興会科学研究費助成事業若手研究(B) 2001年 - 2002年

長山人三

産業財産権

1

特許5840857 細胞障害性Ｔ細胞誘導用組成物

長山人三