2010年7月15日
Eudistomidin G, a new β-carboline alkaloid from the Okinawan marine tunicate Eudistoma glaucus and structure revision of eudistomidin B
Bioorganic and Medicinal Chemistry Letters
- ,
- ,
- ,
- 巻
- 20
- 号
- 14
- 開始ページ
- 4100
- 終了ページ
- 4103
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.bmcl.2010.05.071
- 出版者・発行元
- PERGAMON-ELSEVIER SCIENCE LTD
A new beta-carboline alkaloid, eudistomidin G (1), has been isolated from the Okinawan marine tunicate Eudistoma glaucus, and the structure was elucidated from spectroscopic data. Furthermore, the structure of eudistomidin B (2), which has been isolated from the same tunicate, was revised from 2a to 2b by detailed analyses of spectroscopic data. Asymmetric synthesis of the revised structure (2b) of eudistomidin B (2) and its (1S, 10S)-diastereomer (2c) has been accomplished with the Noyori catalytic asymmetric hydrogen-transfer reaction. The absolute configuration of eudistomidin B (2) was confirmed to be 2b possessing (1R, 10S)-configuration, from comparison of the (1)H NMR data, CD spectra, [a] D values, and HPLC analysis of 2b, 2c, and natural eudistomidin B. (C) 2010 Elsevier Ltd. All rights reserved.
- リンク情報
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- DOI
- https://doi.org/10.1016/j.bmcl.2010.05.071
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/20541407
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000279258800024&DestApp=WOS_CPL
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77953870936&origin=inward
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=77953870936&origin=inward
- URL
- http://orcid.org/0000-0002-3553-5844
- ID情報
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- DOI : 10.1016/j.bmcl.2010.05.071
- ISSN : 0960-894X
- ORCIDのPut Code : 21983988
- PubMed ID : 20541407
- SCOPUS ID : 77953870936
- Web of Science ID : WOS:000279258800024