2017年10月
Molecular Characterization of Fluoroquinolone-Resistant Moraxella catarrhalis Variants Generated In Vitro by Stepwise Selection.
Antimicrobial agents and chemotherapy
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- 巻
- 61
- 号
- 10
- 開始ページ
- e01336-17
- 終了ページ
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1128/AAC.01336-17
Moraxella catarrhalis causes respiratory infections. In this study, fluoroquinolone-resistant strains were selected in vitro to evaluate the mechanism of fluoroquinolone resistance. Strains with reduced fluoroquinolone susceptibility were obtained by stepwise selection in levofloxacin, and fluoroquinolone targets gyr and par were sequenced. Six novel mutations in GyrA (D84Y, T594dup, and A722dup), GyrB (E479K and D439N), and ParE (Q395R) involved in M. catarrhalis resistance to fluoroquinolones were revealed.
- リンク情報
- ID情報
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- DOI : 10.1128/AAC.01336-17
- ISSN : 1098-6596
- PubMed ID : 28760904
- PubMed Central 記事ID : PMC5610493