2011年
哺乳動物フォルミンmDia1の回転運動の細胞骨格への役割
生物物理
- ,
- 巻
- 51
- 号
- 5
- 開始ページ
- 218-221 (J-STAGE)
- 終了ページ
- 221
- 記述言語
- 日本語
- 掲載種別
- DOI
- 10.2142/biophys.51.218
- 出版者・発行元
- The Biophysical Society of Japan General Incorporated Association
Formin homology proteins (formins) play critical roles in the formation of actin stress fibers, the yeast actin cable and the cytokinetic contractile ring. Formins bind around the barbed end and processively elongate the actin filament (F-actin). However, it is unclear how and where in the cell formins form these actin-based structures. Here, we show the rotational movement of a mammalian formin mDia1 along the long-pitch helix of F-actin during processive elongation and depolymerization. From these properties, we postulate that helical rotation of formins may regulate actin assembly and filament stabilization during processive F-actin elongation.<br>
- リンク情報
- ID情報
-
- DOI : 10.2142/biophys.51.218
- ISSN : 0582-4052
- J-Global ID : 201102227421877992
- CiNii Articles ID : 10029482460
- CiNii Books ID : AN00129693