2010年7月
Yamabushitake Mushroom (Hericium erinaceus) Improved Lipid Metabolism in Mice Fed a High-Fat Diet
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
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- 巻
- 74
- 号
- 7
- 開始ページ
- 1447
- 終了ページ
- 1451
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1271/bbb.100130
- 出版者・発行元
- TAYLOR & FRANCIS LTD
The effects of dietary Yamabushitake mushroom (Hericium erinaceus) on lipid metabolism were examined. C57BL/6J mice were fed a high-fat diet containing hot-water extract (HW-E) and an ethanol extract (EtOH-E) of Yamabushitake mushroom. Administration of HW-E or EtOH-E with a high-fat diet for 28d resulted in a significant decrease in body weight gain, fat weight, and serum and hepatic triacylglycerol levels. Our in vitro experiments indicated that EtOH-E acts as an agonist of peroxisome proliferator-activated receptor alpha (PPAR alpha). Quantitative analyses of hepatic mRNA levels revealed that EtOH-E administration resulted in up-regulation of mRNA for a number of PPAR alpha-regulating genes in spite of the fact that the gene expression of PPAR alpha did not change. These results suggest that EtOH-E improves lipid metabolism in mice fed a high-fat diet, and that these effects were mediated by modulation of lipid metabolic gene expression, at least in part via activation of PPAR alpha.
- リンク情報
- ID情報
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- DOI : 10.1271/bbb.100130
- ISSN : 0916-8451
- eISSN : 1347-6947
- PubMed ID : 20622452
- Web of Science ID : WOS:000280458200021