Tetsuya Okada

Profile Information

Affiliation: Instuctor, Graduate School of Science, Division of Biological Sciences, Department of Biophysics, Graduate School of Science, Kyoto University

Degree: Doctor (Life Science)(Kyoto University)
Master (Life Science)(Kyoto University)

J-GLOBAL ID: 200901092791788790
researchmap Member ID: 5000081687

External link: http://www.users.kudpc.kyoto-u.ac.jp/~s50218/mori/

Research Interests

Research Areas

Research History

Apr, 2007

助教, 大学院理学研究科, 京都大学
Apr, 2004

Graduate School of Science, Kyoto University

Education

Papers

Proteomic analysis of fatty liver induced by starvation of medaka fish larvae.

Tomoyo Ikeda, Tokiro Ishikawa, Satoshi Ninagawa, Tetsuya Okada, Masaya Ono, Kazutoshi Mori

Cell structure and function, 48(2) 123-133, Jul 19, 2023
Activation of XBP1 but not ATF6α rescues heart failure induced by persistent ER stress in medaka fish

Byungseok Jin, Tokiro Ishikawa, Makoto Kashima, Rei Komura, Hiromi Hirata, Tetsuya Okada, Kazutoshi Mori

Life Science Alliance, 6(7) e202201771-e202201771, May 9, 2023
Loss of ATF6α in a Human Carcinoma Cell Line Is Compensated not by Its Paralogue ATF6β but by Sustained Activation of the IRE1 and PERK Arms for Tumor Growth in Nude Mice

Shengyu Jin, Byungseok Jin, Tokiro Ishikawa, Satoshi Ninagawa, Tetsuya Okada, Sho Koyasu, Hiroshi Harada, Kazutoshi Mori

Molecular Biology of the Cell, Jan 25, 2023
Loss of ATF6α in a Human Carcinoma Cell Line Is Compensated not by Its Paralogue ATF6β but by Sustained Activation of the IRE1 and PERK Arms for Tumor Growth in Nude Mice.

Shengyu Jin, Byungseok Jin, Tokiro Ishikawa, Satoshi Ninagawa, Tetsuya Okada, Sho Koyasu, Hiroshi Harada, Kazutoshi Mori

Molecular biology of the cell, mbcE22070292, Jan 25, 2023
A motor neuron disease-associated mutation produces non-glycosylated Seipin that induces ER stress and apoptosis by inactivating SERCA2b.

Shunsuke Saito, Tokiro Ishikawa, Satoshi Ninagawa, Tetsuya Okada, Kazutoshi Mori

eLife, 11, Nov 29, 2022
Purified EDEM3 or EDEM1 alone produces determinant oligosaccharide structures from M8B in mammalian glycoprotein ERAD

Ginto George, Satoshi Ninagawa, Hirokazu Yagi, Jun-ichi Furukawa, Noritaka Hashii, Akiko Ishii-Watabe, Ying Deng, Kazutoshi Matsushita, Tokiro Ishikawa, Yugoviandi P Mamahit …

eLife, 10 e70357, Oct 26, 2021 Peer-reviewedCorresponding author
Endoplasmic reticulum-associated degradation controls virus protein homeostasis that is required for the flavivirus propagation

Keisuke Tabata, Masashi Arakawa, Kotaro Ishida, Makiko Kobayashi, Atsuki Nara, Takehiro Sugimoto, Tetsuya Okada, Kazutoshi Mori, Eiji Morita

Journal of Virology, 95(15) e02234, May 12, 2021 Peer-reviewed
EDEM2 stably disulfide-bonded to TXNDC11 catalyzes the first mannose trimming step in mammalian glycoprotein ERAD.

Ginto George, Satoshi Ninagawa, Hirokazu Yagi, Taiki Saito, Tokiro Ishikawa, Tetsushi Sakuma, Takashi Yamamoto, Koshi Imami, Yasushi Ishihama, Koichi Kato …

eLife, 9 e53455, Feb 17, 2020 Peer-reviewedCorresponding author
Development of a Rapid in vivo Assay to Evaluate the Efficacy of IRE1-specific Inhibitors of the Unfolded Protein Response Using Medaka Fish.

Byungseok Jin, Tokiro Ishikawa, Mai Taniguchi, Satoshi Ninagawa, Tetsuya Okada, Shigehide Kagaya, Kazutoshi Mori

Cell structure and function, 45(1) 23-31, Feb 7, 2020 Peer-reviewed
Reinvestigation of Disulfide-bonded Oligomeric Forms of the Unfolded Protein Response Transducer ATF6.

Hibiki Koba, Shengyu Jin, Nanami Imada, Tokiro Ishikawa, Satoshi Ninagawa, Tetsuya Okada, Tetsushi Sakuma, Takashi Yamamoto, Kazutoshi Mori

Cell structure and function, 45(1) 9-21, Jan 30, 2020 Peer-reviewed
UPR transducer BBF2H7 allows export of type II collagen in a cargo- and developmental stage-specific manner.

T. Ishikawa, T. Toyama, Y. Nakamura, K. Tamada, H. Shimizu, S. Ninagawa, T. Okada, Y. Kamei, T. Ishikawa-Fujiwara, T. Todo …

The Journal of Cell Biology, 216(6) 1761-1774, May, 2017 Peer-reviewed
SEL1L-dependent Substrates Require Derlin2/3 and Herp1/2 for Endoplasmic Reticulum-associated Degradation

Takehiro Sugimoto, Satoshi Ninagawa, Shimpei Yamano, Tokiro Ishikawa, Tetsuya Okada, Shunichi Takeda, Kazutoshi Mori

CELL STRUCTURE AND FUNCTION, 42(2) 81-94, 2017 Peer-reviewed
A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Models

Natalia J. Martinez, Ganesha Rai, Adam Yasgar, Wendy A. Lea, Hongmao Sun, Yuhong Wang, Diane K. Luci, Shyh-Ming Yang, Kana Nishihara, Shunichi Takeda …

PLOS ONE, 11(8), Aug, 2016 Peer-reviewed
Forcible destruction of severely misfolded mammalian glycoproteins by the non-glycoprotein ERAD pathway

Satoshi Ninagawa, Tetsuya Okada, Yoshiki Sumitomo, Satoshi Horimoto, Takehiro Sugimoto, Tokiro Ishikawa, Shunichi Takeda, Takashi Yamamoto, Tadashi Suzuki, Yukiko Kamiya …

JOURNAL OF CELL BIOLOGY, 211(4) 775-784, Nov, 2015 Peer-reviewed
EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step

Satoshi Ninagawa, Tetsuya Okada, Yoshiki Sumitomo, Yukiko Kamiya, Koichi Kato, Satoshi Horimoto, Tokiro Ishikawa, Shunichi Takeda, Tetsushi Sakuma, Takashi Yamamoto …

JOURNAL OF CELL BIOLOGY, 206(3) 347-356, Aug, 2014 Peer-reviewed
The Unfolded Protein Response Transducer ATF6 Represents a Novel Transmembrane-type Endoplasmic Reticulum-associated Degradation Substrate Requiring Both Mannose Trimming and SEL1L Protein

Satoshi Horimoto, Satoshi Ninagawa, Tetsuya Okada, Hibiki Koba, Takehiro Sugimoto, Yukiko Kamiya, Koichi Kato, Shunichi Takeda, Kazutoshi Mori

JOURNAL OF BIOLOGICAL CHEMISTRY, 288(44) 31517-31527, Nov, 2013 Peer-reviewed
ATF6 alpha/beta-mediated adjustment of ER chaperone levels is essential for development of the notochord in medaka fish

Tokiro Ishikawa, Tetsuya Okada, Tomoko Ishikawa-Fujiwara, Takeshi Todo, Yasuhiro Kamei, Shuji Shigenobu, Minoru Tanaka, Taro L. Saito, Jun Yoshimura, Shinichi Morishita …

MOLECULAR BIOLOGY OF THE CELL, 24(9) 1387-1395, May, 2013 Peer-reviewed
The antipsychotic olanzapine induces apoptosis in insulin-secreting pancreatic β cells by blocking perk-mediated translational attenuation

Riwa Ozasa, Tetsuya Okada, Satomi Nadanaka, Takahiko Nagamine, Alisha Zyryanova, Heather Harding, David Ron, Kazutoshi Mori

Cell Structure and Function, 38(2) 183-194, 2013 Peer-reviewed
An IFN-gamma-stimulated ATF6-C/EBP-beta-signaling pathway critical for the expression of Death Associated Protein Kinase 1 and induction of autophagy

Padmaja Gade, Girish Ramachandran, Uday B. Maachani, Mark A. Rizzo, Tetsuya Okada, Ron Prywes, Alan S. Cross, Kazutoshi Mori, Dhananjaya V. Kalvakolanu

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(26) 10316-10321, Jun, 2012 Peer-reviewed
A Thrombospondin-Dependent Pathway for a Protective ER Stress Response

Jeffrey M. Lynch, Marjorie Maillet, Davy Vanhoutte, Aryn Schloemer, Michelle A. Sargent, N. Scott Blair, Kaari A. Lynch, Tetsuya Okada, Bruce J. Aronow, Hanna Osinska …

CELL, 149(6) 1257-1268, Jun, 2012 Peer-reviewed

Misc.

高等動物におけるN型糖鎖トリミングを基軸とした小胞体関連分解機構の解析

蜷川暁, GEORGE Ginto, 矢木宏和, 住友嘉樹, 神谷由紀子, 石川時郎, 武田俊一, 佐久間哲史, 山本卓, 加藤晃一 …

日本糖質学会年会要旨集, 38th, 2019
小胞体に存在する複数のオルガネラ・ゾーン

森和俊, 岡田徹也

生体の科学, 69(6) 527-531, Dec, 2018
Mannose trimming mechanism in endoplasmic reticulum-associated degradation of glycoproteins

Tetsuya Okada, Satoshi Ninagawa, Kazutoshi Mori

Seikagaku, 88(2) 257-260, 2016 Peer-reviewed
生き物たちのつづれ織り（下）第５章-１「タンパク合成を支える細胞内システム」

岡田徹也

3-14, 2012 Lead author
小胞体膜結合性転写因子ATF6を小胞体ストレス依存的に還元する仕組みの解析

佐藤吉美, 灘中里美, 岡田徹也, 森和俊

生化学, 2009
膜結合性転写因子ATF6を小胞体ストレス依存的に還元する仕組みの解析

佐藤吉美, 灘中里美, 岡田徹也, 森和俊

生化学, 2007
小胞体ストレスに応答して活性化される転写因子

岡田徹也, 森和俊

脳21, 5 121-125, 2002 Lead author

Presentations

The regulation by OS9 and XTP3B in ER-associated degradation depends on the degree of structural abnormality of degradation substrates

松下和智, 蜷川暁, 杉本岳大, 岡田徹也, 石川時郎, 佐久間哲史, 山本卓, 森和俊

日本糖質学会年会要旨集, 2021
Super-resolution live cell imaging of endoplasmic reticulum stress-induced transport of the membrane-bound transcription factor ATF6.

Okada Tetsuya, Mori Kazutoshi

Dec 2, 2020 Invited
超解像イメージングによる小胞体ストレスセンサーATF6選別輸送ゾーンの解析

岡田徹也, 森和俊

第３回オルガネラ・ゾーン研究会, Nov 27, 2019 Invited
小胞体膜タンパク質Seipinの神経変性誘導変異体に起因する小胞体ストレス発生機構の解析

齊藤峻介, 石川時郎, 蜷川暁, 岡田徹也, 森和俊

日本生化学会大会プログラム・講演要旨集, Sep, 2019, (公社)日本生化学会
小胞体ストレスセンサーATF6αはジスルフィド結合を介して2種類の二量体を形成する(Endoplasmic reticulum stress sensor ATF6α forms two types of dimers via disulfide-bonding)

古場玲, 金聖宇, 岡田徹也, 石川時郎, 蜷川暁, 森和俊

日本生化学会大会プログラム・講演要旨集, Sep, 2019, (公社)日本生化学会
メダカを用いた小胞体ストレスに起因するアポトーシス分子機構の解析

陳炳碩, 石川時郎, 蜷川暁, 岡田徹也, 森和俊

日本生化学会大会プログラム・講演要旨集, Sep, 2019, (公社)日本生化学会
タンパク質の品質管理に関わる小胞体内ゾーンの解析

岡田徹也, 杉本岳大, 蜷川暁, 石川時郎, 森和俊

第41回日本分子生物学会年会, Nov 28, 2018 Invited
タンパク質の品質管理を担う小胞体内オルガネラ・ゾーン

岡田徹也, 森和俊

日本薬学会第138年会, Mar 19, 2018 Invited
小胞体の恒常性維持における膜結合性転写因子ATF6の役割

岡田徹也

第89回日本薬理学会年会年会企画ワークショップ「小胞体ストレス入門」, Mar, 2016 Invited
Derlin2/3およびHerp1/2はSEL1L依存的な構造異常タンパク質分解経路に必要である

杉本岳大, 蜷川暁, 山野晋平, 石川時郎, 岡田徹也, 武田俊一, 森和俊

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec, 2015, (公社)日本生化学会
The unfolded protein response in chicken DT40 cell line: A novel tool for comprehensive genetic analysis of the mammalian-type unfolded protein response

OKADA Tetsuya, Mori Kazutoshi

FASEB summer research conference, 2010
Role of XBP1-ATF6 heterodimerization in the mammalian unfolded protein response

Tetsuya Okada, Toshie Matsui, Hiderou Yoshida, Kazutoshi Mori

Summer Research Conferences-From Unfolded Proteins in the Endoplasmic Reticulum to Desease, Aug, 2007
Darlin-2 and Darlin-3 regulated by mammalian Unfolded Protein Response are required for ER-associated Degradation.

Yukako Oda, Tetsuya Okada, Hiderou Yoshida, Randal J. kaufman, Kazuhiro Nagata, Kazutoshi Mori

International Symposium on Life of Proteins, Awaji （Japan）, 2005. 10. 30－11.3, Oct 30, 2005
CERD, a novel component of ER-associated degradation machinery, regulated by the IRE1－XBP1 pathway.

Tetsuya Okada, Yukako Oda, Hiderou Yoshida, Randal J. Kaufman, Kazuhiro Nagata, Kazutoshi Mori

FASEB 2004 Summer Reserch Conferences（2004.9.31～8.5. Vermont （USA）, 2004
IRE1－XBP1 経路で制御される新規遺伝子CERD1/Derlin－2 の機能解析

小田裕香子, 岡田徹也, 吉田秀郎, Randal J. Kaufman, 永田和宏, 森和俊

第27 回日本分子生物学会大会（2004.12.9. 神戸市）, 2004

Professional Memberships

Research Projects

Regulation of ER-localized mannosidase EDEM2 via the intermolecular disulfide bond

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

Okada Tetsuya
Substrate recognition mechanism of the endoplasmic reticulum-localized mannosidase EDEM

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Okada Tetsuya
Elucidation of regulation mechanism of the endoplasmic reticulum membrane-bound transcription factor ATF6 and its role in the evolution of vertebrates

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

Mori Kazutoshi, OKADA Tetsuya, ISHIKAWA Tokiro, TAKEDA Shunichi, YAMAMOTO Takashi, KATO Koichi, NINAGAWA Satoshi
Establishment of high-throughput screening of toxic chemical compounds.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (S), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2016

Takeda Shunichi, HIROTA Kouji, YAMADA Ryo, OKADA Tetsuya, SASANUMA Hiroyuki, SHIMIZU Hiroyasu, TAKAHASHI Ryosuke
The activation mechanism of a membrane-bound transcription factor ATF6 in response to Endoplasmic Reticulum Stress

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2009 - 2010

OKADA Tetsuya
Mechanism for the specific activation of a membrane-bound transcription factor ATF6 by Endoplasmic Reticulum Stress

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2007 - 2008

OKADA Tetsuya
小胞体膜結合性転写因子ATF6の活性化に関与する小胞輸送の分子機構解析

科学研究費助成事業, 若手研究(B), 日本学術振興会, 2005 - 2006

岡田徹也

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