OKAMOTO Hidehiko

J-GLOBAL         Last updated: Mar 14, 2019 at 11:08
OKAMOTO Hidehiko
International University of Health and Welfare
Department of Integrative Physiology, 感覚運動調節研究部門
Job title
associate professor
Research funding number

Research Interests


Research Areas


Academic & Professional Experience

Apr 2017
Professor, Department of Physiology, School of Medicine, International University of Health and Welfare (IUHW)
Apr 2014
Mar 2017
Associate Professor, Department of Integrative Physiology, National Institute for Physiological Sciences
Aug 2010
Mar 2014
Associate Professor, Department of Integrative Physiology, National Institute for Physiological Sciences
Oct 2005
Jul 2010
Postdoctoral fellow, Institute for Biomagnetism and Biosignalanalysis, University of Muenster
Oct 2004
Aug 2005
Clinical fellow, Department of Otorhinolaryngology and Sensory Organ Surgery, Osaka University Hospital
Jun 2001
Sep 2004
Research Fellow, Department of Integrative Physiology, National Institute for Physiological Sciences, Okazaki, Japan.
Sep 2001
Nov 2003
Research fellow, Rotman Research Institute, Baycrest Centre, University of Toronto, Canada
Feb 2000
May 2001
Resident in Osaka Seamen’s Insurance Hospital, Osaka, Japan.
Feb 2000
May 2001
Resident, Department of otorhinolaryngology, Osaka seamen's hospital
Apr 1999
Jan 2000
Resident, Otorhinolaryngology and Sensory Organ Surgery, Osaka University Hospital

Published Papers

Hidehiko Okamoto, Ryusuke Kakigi
Brain and Nerve   70 467-471   Apr 2018   [Invited]
© 2018 Igaku-Shoin Ltd. All rights reserved. Subjective tinnitus is one of the most common diseases in industrialized countries; however, the mechanisms of tinnitus generation and maintenance remain elusive. Currently, there are no objective param...
Hidehiko Okamoto, Hidehiko Okamoto, Ryusuke Kakigi, Ryusuke Kakigi
Frontiers in Human Neuroscience   11    Feb 2017   [Refereed]
© 2017 Okamoto and Kakigi. In our daily life, we are successively exposed to frequency-modulated (FM) sounds that play an important role in speech and species-specific communication. Previous studies demonstrated that repetitive exposure to identi...
Sekiya K, Takahashi M, Murakami S, Kakigi R, Okamoto H
Journal of Neurophysiology   117(3) 1379-1384   Jan 2017   [Refereed]
Kondo E, Jinnouchi O, Nakano S, Ohnishi H, Kawata I, Okamoto H, Takeda N
Clinical interventions in aging   12 1921-1928   2017   [Refereed]
Kitahara T, Okamoto H, Fukushima M, Sakagami M, Ito T, Yamashita A, Ota I, Yamanaka T
PloS one   11(6) e0158309   Jun 2016   [Refereed]
Sekiya K, Fukushima M, Teismann H, Lagemann L, Pantev C, Okamoto H
Journal of Visualized Experiments   107 e53264   Jan 2016   [Refereed]
Okamoto H, Kakigi R
Scientific Reports   5 e18143   Dec 2015   [Refereed]
Keceli S, Okamoto H, Kakigi R
Brain topography   28(3) 459-470   May 2015   [Refereed]
Okamoto H, Kakigi R
The European journal of neuroscience   40(9) 3380-3386   Nov 2014   [Refereed]
Okamoto H, Fukushima M, Teismann H, Lagemann L, Kitahara T, Inohara H, Kakigi R, Pantev C
Scientific reports   4 3927   Jan 2014   [Refereed]
Okamoto H, Kakigi R
Brain and behavior   4(6) 858-866   2014   [Refereed]
Kondo E, Jinnouchi O, Ohnishi H, Kawata I, Nakano S, Goda M, Kitamura Y, Abe K, Hoshikawa H, Okamoto H, Takeda N
Clinical interventions in aging   9 1661-1667   2014   [Refereed]
Teismann H, Wollbrink A, Okamoto H, Schlaug G, Rudack C, Pantev C
PloS one   9(2) e89904   2014   [Refereed]
Okamoto H, Teismann H, Keceli S, Pantev C, Kakigi R
Behavioral and brain functions   9 44   Dec 2013   [Refereed]
Stein A, Engell A, Okamoto H, Wollbrink A, Lau P, Wunderlich R, Rudack C, Pantev C
PloS one   8(12) e80899   2013   [Refereed]
Pantev C, Okamoto H, Teismann H
Annals of the New York Academy of Sciences   1252 253-258   Apr 2012   [Refereed]
Keceli S, Inui K, Okamoto H, Otsuru N, Kakigi R
BMC neuroscience   13 7   Jan 2012   [Refereed]
Pantev C, Okamoto H, Teismann H
Frontiers in systems neuroscience   6 50   2012   [Refereed]
Okamoto H, Teismann H, Kakigi R, Pantev C
Frontiers in psychology   3 149   2012   [Refereed]
Lagemann L, Okamoto H, Teismann H, Pantev C
PloS one   7(2) e31634   2012   [Refereed]
Teismann H, Okamoto H, Pantev C
PLoS ONE   6    Sep 2011   [Refereed]
Tinnitus is one of the most common diseases in industrialized countries. Here, we developed and evaluated a short-term (5 subsequent days) and intensive (6 hours/day) tailor-made notched music training (TMNMT) for patients suffering from chronic, ...
Okamoto H, Stracke H, Bermudez P, Pantev C
Journal of Cognitive Neuroscience   23 1855-1863   Aug 2011   [Refereed]
Both attention and masking sounds can alter auditory neural processes and affect auditory signal perception. In the present study, we investigated the complex effects of auditory-focused attention and the signal-to-noise ratio of sound stimuli on ...
Okamoto H, Teismann H, Kakigi R, Pantev C
PLoS ONE   6    Mar 2011   [Refereed]
Nowadays, many people use portable players to enrich their daily life with enjoyable music. However, in noisy environments, the player volume is often set to extremely high levels in order to drown out the intense ambient noise and satisfy the app...
Lagemann L, Okamoto H, Teismann H, Pantev C
BMC Neuroscience   11    Dec 2010   [Refereed]
Background: Auditory evoked responses can be modulated by both the sequencing and the signal-to-noise ratio of auditory stimuli. Constant sequencing as well as intense masking sounds basically lead to N1m response amplitude reduction. However, the...
Henning Stracke, Hidehiko Okamoto, Christo Pantev
Communicative and Integrative Biology   3 274-277   May 2010   [Refereed]
Chronic tinnitus is a symptom with high prevalence. There is evidence that the tinnitus perception is related to unfavorable cortical plastic changes. In our recent study we have developed and evaluated a customized music training strategy that ap...
Okamoto H, Stracke H, Lagemann L, Pantev C
IFMBE Proceedings   28 318-321   May 2010   [Refereed]
Under natural environments, picking up relevant sound signals, which are embedded in other irrelevant sound signals, is an important ability for animals including humans. Bottom-up and top-down driven attention seems to play an important role in t...
Okamoto H., Stracke H., Lagemann L., Pantev C.
Journal of Neurophysiology   103(1) 244-249   Jan 2010   [Refereed]
The capability of involuntarily tracking certain sound signals during the simultaneous presence of noise is essential in human daily life. Previous studies have demonstrated that top-down auditory focused attention can enhance excitatory and inhib...
Hidehiko Okamoto, Henning Stracke, Wolfgang Stoll, Christo Pantev
Proceedings of the National Academy of Sciences of the United States of America   107 1207-1210   Jan 2010   [Refereed]
Maladaptive auditory cortex reorganization may contribute to the generation and maintenance of tinnitus. Because cortical organization can be modified by behavioral training, we attempted to reduce tinnitus loudness by exposing chronic tinnitus pa...
Draganova R., Wollbrink A., Schulz M., Okamoto H., Pantev C
BMC Neuroscience   10 143   Dec 2009   [Refereed]
Background: Due to auditory experience, musicians have better auditory expertise than non-musicians. An increased neocortical activity during auditory oddball stimulation was observed in different studies for musicians and for non-musicians after ...
Okamoto H., Stracke H., Draganova R., Pantev C.
Cerebral Cortex   19(10) 2290-2297   Oct 2009   [Refereed]
The investigation of functional hemispheric asymmetries regarding auditory processing in the human brain still remains a challenge. Classical lesion and recent neuroimaging studies indicated that speech is dominantly processed in the left hemisphe...
Stracke H, Okamoto H, Pantev C.
Cerebral Cortex   19(6) 1440-1447   Jun 2009   [Refereed]
We investigated attentional effects on human auditory signal-in-noise processing in a simultaneous masking paradigm using magnetoencephalography. Test signal was a monaural 1000-Hz tone; maskers were binaural band-eliminated noises (BENs) containi...
Okamoto H., Stracke H., Zwitserlood P., Roberts LE., Pantev C.
BMC Neuroscience   10 1   Jan 2009   [Refereed]
Background: Under natural circumstances, attention plays an important role in extracting relevant auditory signals from simultaneously present, irrelevant noises. Excitatory and inhibitory neural activity, enhanced by attentional processes, seems ...
Okamoto H, Stracke H, Pantev C.
Neuroscience   151(3) 913-920   Feb 2008   [Refereed]
Neural activities elicited in the auditory system are systematically organized according to the frequency characteristics of corresponding sound inputs. This systematic frequency alignment, called 'tonotopy,' plays an important role in auditory pe...
Okamoto H, Stracke H, Wolters CH, Schmael F, Pantev C
J Neurosci.   27 10383-10390   Sep 2007   [Refereed]
Attention improves auditory performance in noisy environments by either enhancing the processing of task-relevant stimuli ("gain"), suppressing task-irrelevant information ("sharpening"), or both. In the present study, we investigated the effect o...
Okamoto H, Kakigi R, Gunji A, Pantev C
BMC Neuroscience   8    May 2007   [Refereed]
Background: Decrements of auditory evoked responses elicited by repeatedly presented sounds with similar frequencies have been well investigated by means of electroencephalography and magnetoencephalography (MEG). However the possible inhibitory i...
Hoshiyama M, Okamoto H, Kakigi R.
Eur J Neurosci.   25 854-862   Feb 2007   [Refereed]
We analysed two different neural mechanisms related to the unconscious processing of auditory stimulation, neural adaptation and mismatch negativity (MMN), using magnetoencephalography in healthy non-musicians. Four kinds of conditioning stimulus ...
Okamoto H, Stracke H, Ross B, Kakigi R, Pantev C
BMC Biology   5    Jan 2007   [Refereed]
Background: In daily life, we are exposed to different sound inputs simultaneously. During neural encoding in the auditory pathway, neural activities elicited by these different sounds interact with each other. In the present study, we investigate...
Inui K, Okamoto H, Miki K, Gunji A, Kakigi R
Cereb Cortex   16(1) 18-30   Jan 2006   [Refereed]
Although anatomical, histochemical and electrophysiological findings in both animals and humans have suggested a parallel and serial mode of auditory processing, precise activation timings of each cortical area are not well known, especially in hu...
Okamoto H, Kakigi R, Gunji A, Kubo T, Pantev C
European Journal of Neuroscience   21 1957-1961   Apr 2005   [Refereed]
The auditory evoked response is known to be changed by a preceding sound. In this study we investigated by means of magnetoencephalography how a preceding notch-filtered noise (NFN) with different bandwidths influences the human auditory evoked re...
Okamoto H, Ross B,.Kakigi R, Kubo T, Pantev C
International Congress Series   1278 23-26   Mar 2005   [Refereed]
Stimulating with a noise with strong spectral contrasts resulted in different responsiveness for two types of test stimuli presented after release of the noise. The magnetoencephalographically recorded N1m response to an auditory stimulus, spectra...
Okamoto H., Ross B., Kakigi R., Kubo T., Pantev C.
Hear Res.   196 77-86   Oct 2004   [Refereed]
Comb-filtered noise (CFN, derived from white noise by suppressing regularly spaced frequency regions) was presented for 3 s followed by two types of test stimuli. One test stimulus (SB) was comprised of spectra centered in the stop-band regions of...
Pantev C., Okamoto H., Ross B., Stoll W., Ciurlia-Guy E., Kakigi R., Kubo T.
Eur J Neurosci.   19 2337-2344   Apr 2004   [Refereed]
The goal of this study was to compare the lateral inhibition and the habituation in the human auditory cortex, two important physiological effects during auditory processing that can be reliably measured by means of magnetoencephalography when rec...
Ishii R, Dziewas R, Chau W, Soros P, Okamoto H, Gunji A, Pantev C
Brain and cognition   54 157-159   Mar 2004   [Refereed]
Okamoto H, Ross B, Pantev C
Brain and cognition   54 172-173   Mar 2004   [Refereed]
Gunji A., Koyama S., Ishii R., Levy D., Okamoto H., Kakigi R., Pantev C.
Neurosci Lett.   348 13-16   Sep 2003   [Refereed]
In an attempt to identify voice-specific neural activities in auditory cortex in humans, we recorded cortical magnetic responses. Volunteers were instructed to listen to vocal and instrumental sounds matched in fundamental-frequency, duration, tem...
Fujioka T., Ross B., Okamoto H., Takeshima Y., Kakigi R., Pantev C.
Eur J Neurosci.   18 432-440   Jul 2003   [Refereed]
The N1m component of the auditory evoked magnetic field in response to tones and complex sounds was examined in order to clarify whether the tonotopic representation in the human secondary auditory cortex is based on perceived pitch or the physica...
Ishii R., Dziewas R., Chau W., Soros P., Okamoto H., Gunji A., Pantev C.
Neurosci Lett.   340 25-28   Apr 2003   [Refereed]
Previous magnetoencephalography (MEG) studies of sleep spindles have identified a complex and widespread distribution in parietal and frontal cortices by fitting a dipolar model to the data. In this study, we used a whole-head 151-channel MEG syst...
Aya Nakagawa, Yasuo Mishiro, Yoshifumi Takahashi, Hidehiko Okamoto, Takeshi Kubo, Kenji Mitani
Practica Oto-Rhino-Laryngologica   95 447-453   Jan 2002   [Refereed]
A 35-year-old man who underwent canal down operation for a left middle ear cholesteatoma 30 years earlier, suffered from meningitis. He also developed hoarseness and dysphagia while he was hospitalized. CT and MRI scans showed a mass causing these...


Tinnitus Pathology
OKAMOTO Hidehiko
Journal of Otology, Head and Neck Surgery   35(1) 11-13   Jan 2019
no title
Audiology Japan   61(5) 441-441   Sep 2018
Effects of auditory impairments and auditory rehabilitation on the auditory evoked fields
OKAMOTO Hidehiko et al
The Journal of Japan Biomagnetism and Bioelectromagnetics Society   31(1) 66-67   Jun 2018   [Refereed]
岡本 秀彦, 柿木 隆介
BRAIN and NERVE: 神経研究の進歩   70(4) 0467-0471   Apr 2018
【耳鼻咽喉科医に必要な認知症の知識-認知症と高次脳機能障害】 聴覚失認と皮質聾 聴覚情報の脳内処理過程
岡本 秀彦
JOHNS   34(3) 309-311   Mar 2018
【耳鳴診療のNew Trend】 耳鳴の発生機序
岡本 秀彦
耳鼻咽喉科・頭頸部外科   90(2) 112-115   Feb 2018
聴覚認知の神経生理学的アプローチ ヒト聴覚野におけるマクロレベルでの周波数特異性とその変化
岡本 秀彦
臨床神経生理学   45(5) 309-309   Oct 2017
聴覚認知の神経生理学的アプローチ 両耳分離聴タスクにおける聴覚情報処理の検討
田中 慶太, 高橋 悠太, 小渕 千絵, 原島 恒夫, 岡本 秀彦, 栗城 眞也
臨床神経生理学   45(5) 309-309   Oct 2017
関谷 健一, 高橋 真理子, 村上 信五, 岡本 秀彦
Audiology Japan   60(5) 473-473   Sep 2017
関谷 健一, 高橋 真理子, 村上 信吾, 岡本 秀彦
日本耳鼻咽喉科学会会報   120(4) 528-528   Apr 2017
岡本 秀彦
臨床神経生理学   44(5) 365-365   Oct 2016   [Refereed][Invited]
関谷 健一, 高橋 真理子, 村上 信五, 岡本 秀彦
日本生体磁気学会誌   29(1) 60-61   Jun 2016   [Refereed]
岡本 秀彦, 柿木 隆介
日本生体磁気学会誌   29(1) 62-63   Jun 2016   [Refereed]
Hidehiko Okamoto, Hidehiko Okamoto
Clinical Applications of Magnetoencephalography   113-126   Jan 2016
© Springer Japan 2016. Recent neuroimaging and neurophysiological data suggest that maladaptive cortical reorganization in the human auditory cortex can lead to the emergence of hearing disorders such as subjective tinnitus. Reversing maladaptive ...
Japanese Journal of Clinical Neurophysiology   42 294-294   Nov 2014
Japanese Journal of Clinical Neurophysiology   42 271-271   Nov 2014
The journal of Japan Biomagnetism and Bioelectromgnetics Society   27 82-83   May 2014
岡本秀彦、タイスマンヘンニング、パンテフクリスト、 柿木隆介
The journal of Japan Biomagnetism and Bioelectromgnetics Society   26 274-275   Jun 2013
Cascadic attentional effects on the human auditory evoked responses.
Okamoto H., Teismann H., Pantev C., Kakigi R.
The Journal of Physiological Sciences   62 182-182   Mar 2012
岡本秀彦, Teismann H., Pantev C., 柿木隆介
Japanese Journal of Clinical Neurophysiology   39 471-471   Nov 2011
岡本秀彦, Teismann H., Pantev C., 柿木隆介
Japanese Journal of Clinical Neurophysiology   39 196-197   Nov 2011
A light and a dark side of portable music players.
岡本秀彦, Teismann H., Pantev C., 柿木隆介
Proceeding of the Symposium on Biological and Physiological Engineering   26 40-40   Jul 2011
Basic and clinical findings of lateral inhibition in human auditory cortex.
岡本秀彦, Teismann H., Pantev C., 柿木隆介
The journal of Japan Biomagnetism and Bioelectromgnetics Society   24 42-42   Jun 2011
The effect of repetition rate on auditory sustained magnetic fields.
Keceli S., 乾幸二, 岡本秀彦, 大鶴直史, 柿木隆介
The journal of Japan Biomagnetism and Bioelectromgnetics Society   24 190-191   Jun 2011
Asymmetric lateral inhibitory neural activity in the auditory system: a magnetoencephalographic study. http://www.biomedcentral.com/1471-2202/8/33
Okamoto H, Kakigi R, Gunji A, Pantev C.
BMC Neurosci.   17(8) 33   2007
Okamoto H, Stracke H, Ross B, Kakigi R, Pantev C
BMC Biology   (5) 52   2007
Okamoto H., Kakigi R., Gunji A., Kubo T., Pantev C.
Eur J Neurosci.   21 1957-61   2005
Okamoto H., Stracke H., Bermudez P., Pantev C.
Journal of Cognitive Neuroscience   
in press

Conference Activities & Talks

Investigating the maladaptive cortical reorganization in the human auditory cortex using magnetoencephalography [Invited]
OKAMOTO Hidehiko
Tohoku Universal Acoustical Communication Month 2018   26 Oct 2018   
Physiological studies for tinnitus and sudden deafness [Invited]
OKAMOTO Hidehiko
Evoked Potential Workshop   24 Jun 2018   
Neural activity elicited by frequency-modulated (FM) seeps in human auditory cortex -A magnetoencephalographic study- [Invited]
OKAMOTO Hidehiko
16 Jun 2017   
Auditory evoked fields elicited by repetitive gaps embedded within a continuous tone [Invited]
OKAMOTO Hidehiko
Acoustical Society of America   2 Dec 2016   
Auditory evoked fields elicited by frequency-modulated sweeps
OKAMOTO Hidehiko, KAKIGI Ryusuke
BIOMAG 2016   3 Oct 2016   
Cortical plasticity in human brain
OKAMOTO Hidehiko
1 Aug 2016   
Evoked Magnetic Fields Elicited by Frequency Modulated Sounds
OKAMOTO Hidehiko
20 Jul 2016   
Auditory evoked fields elicited in sudden sensorineural hearing loss patients who received constraint-induced sound therapy
OKAMOTO Hidehiko
23 Oct 2015   
Pre-penultimate Silent Intervals Affects Auditory Evoked Responses Measuered by Magnetoencephalography
29 Jul 2015   

Research Grants & Projects

auditory evoked response
Neural Plasticity