2018年9月
Multi-component intrinsic brain activities as a safe alternative to cortical stimulation for sensori-motor mapping in neurosurgery.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
- 巻
- 129
- 号
- 9
- 開始ページ
- 2038
- 終了ページ
- 2048
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.clinph.2018.06.007
OBJECTIVE: To assess the feasibility of multi-component electrocorticography (ECoG)-based mapping using "wide-spectrum, intrinsic-brain activities" for identifying the primary sensori-motor area (S1-M1). METHODS: We evaluated 14 epilepsy patients with 1514 subdural electrodes implantation covering the perirolandic cortices at Kyoto University Hospital between 2011 and 2016. We performed multi-component, ECoG-based mapping (band-pass filter, 0.016-300/600 Hz) involving combined analyses of the single components: movement-related cortical potential (<0.5-1 Hz), event-related synchronization (76-200 Hz), and event-related de-synchronization (8-24 Hz) to identify the S1-M1. The feasibility of multi-component mapping was assessed through comparisons with single-component mapping and electrical cortical stimulation (ECS). RESULTS: Among 54 functional areas evaluation, ECoG-based maps showed significantly higher rate of localization concordances with ECS maps when the three single-component maps were consistent than when those were inconsistent with each other (p < 0.001 in motor, and p = 0.02 in sensory mappings). Multi-component mapping revealed high sensitivity (89-90%) and specificity (94-97%) as compared with ECS. CONCLUSIONS: Wide-spectrum, multi-component ECoG-based mapping is feasible, having high sensitivity/specificity relative to ECS. SIGNIFICANCE: This safe (non-stimulus) mapping strategy, alternative to ECS, would allow clinicians to rule in/out the possibility of brain function prior to resection surgery.
- リンク情報
- ID情報
-
- DOI : 10.1016/j.clinph.2018.06.007
- ISSN : 1388-2457
- eISSN : 1872-8952
- PubMed ID : 29935961
- SCOPUS ID : 85048835447