Papers

Peer-reviewed
Sep, 2010

Design, synthesis, and biological evaluation of a novel series of quercetin diacylglucosides as potent anti-MRSA and anti-VRE agents

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
  • Abugafar M. L. Hossion
    • ,
  • Nao Otsuka
    • ,
  • Rafiya K. Kandahary
    • ,
  • Tomofusa Tsuchiya
    • ,
  • Wakano Ogawa
    • ,
  • Akimasa Iwado
    • ,
  • Yoshito Zamami
    • ,
  • Kenji Sasaki
Volume
20
Number
17
First page
5349
Last page
5352
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.1016/j.bmcl.2010.02.060
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
A series of novel quercetin diacylglucosides were designed and first synthesized by Steglich esterification on the basis of MRSA strains inhibiting natural compound A. The in vitro inhibition of different multidrug resistant bacterial strains and Escherichia coli DNA gyrase B was investigated. In the series, compound 10h was up to 128-fold more potent against vancomycin-resistant enterococci and more effective than A, which represents a promising new candidate as a potent anti-MRSA and anti-VRE agent. (C) 2010 Published by Elsevier Ltd.
Link information
DOI
https://doi.org/10.1016/j.bmcl.2010.02.060
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/20655215
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000281247000080&DestApp=WOS_CPL
ID information
  • DOI : 10.1016/j.bmcl.2010.02.060
  • ISSN : 0960-894X
  • Pubmed ID : 20655215
  • Web of Science ID : WOS:000281247000080
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