2018年5月1日
Fear memory consolidation in sleep requires protein kinase a
Learning and Memory
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- 巻
- 25
- 号
- 5
- 開始ページ
- 241
- 終了ページ
- 246
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1101/lm.046458.117
- 出版者・発行元
- Cold Spring Harbor Laboratory Press
It is well established that protein kinase A (PKA) is involved in hippocampal dependent memory consolidation. Sleep is also known to play an important role in this process. However, whether sleep-dependent memory consolidation involves PKA activation has not been clearly determined. Using behavioral observation, animals were categorized into sleep and awake groups. We show that intrahippocampal injections of the PKA inhibitor Rp-cAMPs in post-contextual fear conditioning sleep produced a suppression of long-term fear memory, while injections of Rp-cAMPs during an awake state, at a similar time point, had no effect. In contrast, injections of the PKA activator Sp-cAMPs in awake state, rescued sleep deprivation-induced memory impairments. These results suggest that following learning, PKA activation specifically in sleep is required for the consolidation of long-term memory.
- ID情報
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- DOI : 10.1101/lm.046458.117
- ISSN : 1549-5485
- ISSN : 1072-0502
- SCOPUS ID : 85047927418