Seishiro Sawamura

Profile Information

Affiliation: Assistant Professor, Graduate School of Medicine, Osaka University

Degree: 工学(京都大学)

Researcher number: 10781974
J-GLOBAL ID: 201801017266220616
researchmap Member ID: B000301523

Research Interests

Research Areas

Life sciences / Pharmacology /

Research History

Apr, 2021 - Present

Assistant Professor, Division of Glocal Pharmacology, Department of Pharmacology, Graduate School of Medicine, Osaka University
Apr, 2016 - Mar, 2021

Assistant Professor, Graduate School of Medical and Dental Sciences Biological Functions and Medical Control Regenerative and Transplant Medicine, Niigata University

Education

- Mar, 2016

Graduate School, Division of Engineering, Kyoto University
- Mar, 2010

Faculty of Engineering, Kyoto University

Papers

A strategy for low-cost portable monitoring of plasma drug concentrations using a sustainable boron-doped-diamond chip

Takuro Saiki, Genki Ogata, Seishiro Sawamura, Kai Asai, Olga Razvina, Kota Watanabe, Rito Kato, Qi Zhang, Koei Akiyama, Sasya Madhurantakam …

Heliyon, e15963-e15963, May, 2023
In Vivo Real-Time Measurement of Drugs

Genki Ogata, Seishiro Sawamura, Kai Asai, Hiroyuki Kusuhara, Yasuaki Einaga, Hiroshi Hibino

Diamond Electrodes: Fundamentals and Applications, 227-236, Jan 1, 2022
A Method Designed for Point-of-care System Monitoring Plasma Concentration of an Anticancer Molecular Targeting Drug with Diamond Electrode

Takuro Saiki, Ogata Genki, Sawamura Seishiro, Razvina Olga, Watanabe Kota, Kato Rito, Asai Kai, Matsumoto Yoshifumi, Moriyama Masato, Saijo Yasuo …

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 95 2-YIA-58, 2022
A prototype of the microsensing system for in vivo drug monitoring in the skin with diamond electrode

Ahmad Norzahirah Binti, Sawamura Seishiro, Ogata Genki, Einaga Yasuaki, Hibino Hiroshi

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 96 1-B-SS04-6, 2022
A rapid and simple electrochemical detection of the free drug concentration in human serum using boron-doped diamond electrodes

HIdeto Moriyama, Genki Ogata, Haruma Nashimoto, Seishiro Sawamura, Yoshiaki Furukawa, Hiroshi Hibino, Hiroyuki Kusuhara, Yasuaki Einaga

The Analyst, 147(20) 4442-4449, 2022
Author Correction: Computer modeling defines the system driving a constant current crucial for homeostasis in the mammalian cochlea by integrating unique ion transports.

Fumiaki Nin, Takamasa Yoshida, Shingo Murakami, Genki Ogata, Satoru Uetsuka, Samuel Choi, Katsumi Doi, Seishiro Sawamura, Hidenori Inohara, Shizuo Komune …

NPJ systems biology and applications, 7(1) 39-39, Oct 18, 2021
Analysis of Pharmacokinetics in the Cochlea of the Inner Ear.

Seishiro Sawamura, Genki Ogata, Kai Asai, Olga Razvina, Takeru Ota, Qi Zhang, Sasya Madhurantakam, Koei Akiyama, Daisuke Ino, Sho Kanzaki …

Frontiers in pharmacology, 12 633505-633505, 2021
O2-Dependent Protein Internalization Underlies Astrocytic Sensing of Acute Hypoxia by Restricting Multimodal TRPA1 Channel Responses.

Makoto Uchiyama, Akito Nakao, Yuki Kurita, Isato Fukushi, Kotaro Takeda, Tomohiro Numata, Ha Nam Tran, Seishiro Sawamura, Maximilian Ebert, Tatsuki Kurokawa …

Current biology : CB, 30(17) 3378-3396, Sep 7, 2020
In Vivo Real-Time Simultaneous Examination of Drug Kinetics at Two Separate Locations Using Boron-Doped Diamond Microelectrodes.

Ai Hanawa, Genki Ogata, Seishiro Sawamura, Kai Asai, Sho Kanzaki, Hiroshi Hibino, Yasuaki Einaga

Analytical chemistry, 92(20) 13742-13749, Aug 27, 2020 Peer-reviewed
Characterisation of the static offset in the travelling wave in the cochlear basal turn

Takeru Ota, Fumiaki Nin, Samuel Choi, Shogo Muramatsu, Seishiro Sawamura, Genki Ogata, Mitsuo P. Sato, Katsumi Doi, Kentaro Doi, Tetsuro Tsuji …

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, Apr, 2020 Peer-reviewed
A rapid measurement of plasma concentration of a molecular-targeted drugs with diamond sensor.

Ogata Genki, Saiki Takuro, Sawamura Sheishiro, Razvina Olga, Watanabe Kota, Kato Rito, Asai Kai, Hanawa Ai, Matsumoto Yoshifumi, Saijo Yasuo …

Transactions of Japanese Society for Medical and Biological Engineering, Annual58(Abstract) 286-286, 2020
Rapid measurement of plasma concentration of a molecular-targeted agent, pazopanib, with diamond sensor.

Takuro Saiki, Ogata Genki, Kato Rito, Razvina Olga, Sawamura Seishiro, Matsumoto Yoshifumi, Hanawa Ai, Asai Kai, Einaga Yasuaki, Saijo Yasuo …

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 93 1-YIA-18, 2020
Rapid measurement of plasma concentration of a vancomycin with diamond sensor.

Razvina Olga, Saiki Takuro, Ogata Genki, Sawamura Seishiro, Kato Rito, Hanawa Ai, Asai Kai, Saijo Yasuo, Einaga Yasuaki, Hibino Hiroshi

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 93 1-P-133, 2020
Simultaneous and real-time quantification of multiple drugs with a diamond electrode

Sawamura Seishiro, Ogata Genki, Kuwabara Sayaka, Kato Rito, Asai Kai, Razvina Olga, Einaga Yasuaki, Hibino Hiroshi

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 93 2-O-038, 2020
Simultaneous and real-time quantification of multiple drugs with a needle-type diamond electrode

Sawamura Seishiro, Ogata Genki, Kuwabara Sayaka, Kato Rito, Asai Kai, Razvina Olga, Einaga Yasuaki, Hibino Hiroshi

Transactions of Japanese Society for Medical and Biological Engineering, Annual58(Abstract) 461-461, 2020
An offset component associated with the activity of outer hair cells in the cochlear travelling wave

Takeru Ota, Fumiaki Nin, Samuel Choi, Shogo Muramatsu, Seishiro Sawamura, Genki Ogata, Mitsuo P. Sato, Katsumi Doi, Kentaro Doi, Tetsuro Tsuji …

Pflügers Archiv - European Journal of Physiology, 2020 Peer-reviewed
Characterisation of N-glycans in the epithelial-like tissue of the rat cochlea.

Yoriko Nonomura, Seishiro Sawamura, Ken Hanzawa, Takashi Nishikaze, Sadanori Sekiya, Taiga Higuchi, Fumiaki Nin, Satoru Uetsuka, Hidenori Inohara, Shujiro Okuda …

Scientific reports, 9(1) 1551-1551, Feb 7, 2019 Peer-reviewed
Rapid measurement of plasma concentration of a molecular targeted agent, imatinib, with diamond sensor.

Sawamura Seishiro, Razvina Olga, Ogata Genki, Watanabe Kota, Asai Kai, Hanawa Ai, Einaga Yasuaki, Hibino Hiroshi

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 92 1-P-131, 2019
A rapid procedure for measurement of plasma concentration of a molecular target anti-cancer drug with diamond sensor.

Watanabe Kota, Ogata Genki, Sawamura Seishiro, Asai Kai, Hanawa Ai, Einaga Yasuaki, Hibino Hiroshi

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 92 1-P-130, 2019
Erratum to: An approach to the research on ion and water properties in the interphase between the plasma membrane and bulk extracellular solution.

Hiroshi Hibino, Madoka Takai, Hidenori Noguchi, Seishiro Sawamura, Yasufumi Takahashi, Hideki Sakai, Hitoshi Shiku

The journal of physiological sciences : JPS, 68(1) 101-101, Jan, 2018 Peer-reviewed
Hearing Loss Controlled by Optogenetic Stimulation of Nonexcitable Nonglial Cells in the Cochlea of the Inner Ear

Mitsuo P. Sato, Taiga Higuchi, Fumiaki Nin, Genki Ogata, Seishiro Sawamura, Takamasa Yoshida, Takeru Ota, Karin Hori, Shizuo Komune, Satoru Uetsuka …

FRONTIERS IN MOLECULAR NEUROSCIENCE, 10 300, Sep, 2017 Peer-reviewed
A microsensing system for the in vivo real-time detection of local drug kinetics

Genki Ogata, Yuya Ishii, Kai Asai, Yamato Sano, Fumiaki Nin, Takamasa Yoshida, Taiga Higuchi, Seishiro Sawamura, Takeru Ota, Karin Hori …

NATURE BIOMEDICAL ENGINEERING, 1(8) 654-666, Aug, 2017 Peer-reviewed
An approach to the research on ion and water properties in the interphase between the plasma membrane and bulk extracellular solution

Hiroshi Hibino, Madoka Takai, Hidenori Noguchi, Seishiro Sawamura, Yasufumi Takahashi, Hideki Sakai, Hitoshi Shiku

JOURNAL OF PHYSIOLOGICAL SCIENCES, 67(4) 439-445, Jul, 2017 Peer-reviewed
Fibrocytes in the cochlea of the mammalian inner ear: their molecular architecture, physiological properties, and pathological relevance

T. Yoshida, S. Sawamura, T. Ota, T. Higuchi, G. Ogata, K. Hori, T. Nakagawa, K. Doi, M.P. Sato, Y. Nonomura …

Medical Research Archives, 5 1-16, 2017 Peer-reviewed
TRP Channels in the Brain: What Are They There For?

Sawamura S, Shirakawa H, Nakagawa T, Mori Y, Kaneko S, Emir TLR

295-322, 2017 Peer-reviewed
Computer modeling defines the system driving a constant current crucial for homeostasis in the mammalian cochlea by integrating unique ion transports.

Nin F, Yoshida T, Murakami S, Ogata G, Uetsuka S, Choi S, Doi K, Sawamura S, Inohara H, Komune S …

NPJ systems biology and applications, 3 24-24, 2017 Peer-reviewed
The unique electrical properties in an extracellular fluid of the mammalian cochlea; their functional roles, homeostatic processes, and pathological significance

Fumiaki Nin, Takamasa Yoshida, Seishiro Sawamura, Genki Ogata, Takeru Ota, Taiga Higuchi, Shingo Murakami, Katsumi Doi, Yoshihisa Kurachi, Hiroshi Hibino

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 468(10) 1637-1649, Oct, 2016 Peer-reviewed
Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compounds

Seishiro Sawamura, Masahiko Hatano, Yoshinori Takada, Kyosuke Hino, Tetsuya Kawamura, Jun Tanikawa, Hiroshi Nakagawa, Hideharu Hase, Akito Nakao, Mitsuru Hirano …

MOLECULAR PHARMACOLOGY, 89(3) 348-363, Mar, 2016 Peer-reviewed
Elucidation of signal regulation by interacting molecules and proteins of Ca2+ influx channels

Sawamura, Seishiro

Mar, 2016
A screening of TRPC channels activators identifies novel neurotrophic compounds

Sawamura Seishiro, Hatano Masahiko, Sasaki Hajime, Takada Yoshinori, Kuwamura Takashi, Numata Tomohiro, Kiyonaka Shigeki, Hino Kyosuke, Kawamura Tetsuya, Tanikawa Jun …

JOURNAL OF PHARMACOLOGICAL SCIENCES, 128(3) S90-S90, Jul, 2015 Peer-reviewed
Dynamics of receptor-operated Ca2+ currents through TRPC channels controlled via the PI(4,5),P-2-PLC signaling pathway

Masayuki X. Mori, Kyohei Itsuki, Hideharu Hese, Seishiro Sawamura, Tatsuki Kurokawa, Yasuo Mori, Ryuji Inoue

FRONTIERS IN PHARMACOLOGY, 6 22, Feb, 2015 Peer-reviewed
Development of novel activators for TRPC channels aiming to treatment of neurodegenerative disorders

Sawamura Seishiro, Hatano Masahiko, Takada Yoshinori, Kuwamura Takashi, Numata Tomohiro, Kiyonaka Shigeki, Hino Kyosuke, Kawamura Tetsuya, Tanikawa Jun, Nakagawa Hiroshi …

JOURNAL OF PHARMACOLOGICAL SCIENCES, 124 181P, 2014 Peer-reviewed
Voltage-dependent calcium channel beta 4 subunit directly couples electrical activity to gene expression

Seishiro Sawamura, Shigeki Kiyonaka, Takafumi Miki, Satoshi Akiyama, Michel Ronjat, Michel De Waard, Yasuo Mori

JOURNAL OF PHARMACOLOGICAL SCIENCES, 121, 2013
Cacnb4 directly couples electrical activity to gene expression, a process defective in juvenile epilepsy

Abir Tadmouri, Shigeki Kiyonaka, Maud Barbado, Matthieu Rousset, Katell Fablet, Seishiro Sawamura, Eloi Bahembera, Karin Pernet-Gallay, Christophe Arnoult, Takafumi Miki …

EMBO JOURNAL, 31(18) 3730-3744, Sep, 2012 Peer-reviewed
The juvenile myoclonic epilepsy-related protein EFHC1 interacts with the redox-sensitive TRPM2 channel linked to cell death

Masahiro Katano, Tomohiro Numata, Kripamoy Aguan, Yuji Hara, Shigeki Kiyonaka, Shinichiro Yamamoto, Takafumi Miki, Seishiro Sawamura, Toshimitsu Suzuki, Kazuhiro Yamakawa …

CELL CALCIUM, 51(2) 179-185, Feb, 2012 Peer-reviewed
Protein Kinase C delta-specific Activity Reporter Reveals Agonist-evoked Nuclear Activity Controlled by Src Family of Kinases

Taketoshi Kajimoto, Seishiro Sawamura, Yumi Tohyama, Yasuo Mori, Alexandra C. Newton

JOURNAL OF BIOLOGICAL CHEMISTRY, 285(53) 41896-41910, Dec, 2010 Peer-reviewed

Misc.

針状ダイヤモンド電極を駆使した脳の薬物モニタリングシステムの創出—Development of an advanced drug monitoring system for the brain with needle-type diamond electrode—研究者の最新動向

澤村晴志朗, 緒方元気, 栄長泰明, 日比野浩

Precision medicine = プレシジョンメディシン / 「Precision medicine」編集委員会編, 5(7) 645-647, Jul, 2022
A strategy for rapid and easy measurement of plasma concentration of pazopanib

緒方元気, 齋木琢郎, 齋木琢郎, 澤村晴志朗, RAZVINA Olga, 渡邉航太, 加藤理都, 浅井開, 花輪藍, 松本吉史 …

日本生体医工学会大会プログラム・抄録集(Web), 60th, 2021
ダイヤモンド電極を用いた電気化学測定による薬物血中濃度の迅速測定

齋木琢郎, 齋木琢郎, 緒方元気, 澤村晴志朗, ラズビナオリガ, 渡邊航太, 加藤里都, 浅井開, 松本吉史, 森山雅人 …

日本生理学雑誌(Web), 83(2), 2021
[Development of in vivo drug sensing system with needle-type diamond microelectrode].

Ogata G, Asai K, Sano Y, Sawamura S, Takai M, Kusuhara H, Einaga Y, Hibino H

Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 153(6) 273-277, 2019 Peer-reviewed
生体内局所の薬物動態とその作用をリアルタイム計測する薬物モニターシステムの活用

日本生理学雑誌(Web), 80(1) WEB ONLY, Feb, 2018
カリウム in 神経系のトランスポーター – Up to date

HIBINO Hiroshi

Clinical Neuroscience, 36(6) 687-691, 2018
電位依存性カルシウムチャネル

澤村晴志朗, 中尾章人, 森泰生

脳科学辞典（担当編集委員：林康紀）, 2013 Peer-reviewedInvited

Teaching Experience

May, 2021

Introduction to Biological Science (Osaka University)
Apr, 2021

Pharmacology (Osaka University)
病態薬理学 (新潟大学)
生理学実習 (新潟大学)
生理学Ⅱ (新潟大学)

Professional Memberships

Research Projects

生体局所での薬物相互作用を定量する革新的薬物センサシステムの創出

科学研究費助成事業若手研究, 若手研究, 日本学術振興会, Apr, 2020 - Mar, 2023

澤村晴志朗
Establishment and applications of model mice with fluctuated deafness by advanced gene-engineering methods

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2022

Hibino Hiroshi
Development of skin patch wearable drug sensor

Apr, 2021 - Mar, 2022
Elucidation of molecular entities responsible for unique electrochemical property of the cochlear lateral wall

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

Sawamura Seishiro
内耳の上皮組織を標的とした光遺伝学による新規難聴モデルマウスの確立

山口育英奨学会学術研究助成, 民間財団等, Jun, 2017 - May, 2018

澤村晴志朗

Profile Information

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Research History

Education

Papers

Misc.

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