SAKI SHIRAKO - My portal

Profile Information

Affiliation: Assistant Professor, College of Life Sciences Department of Biomedical Sciences, Ritsumeikan University

Degree: Ph.D. (Agriculture)(Mar, 2020, Kyoto University)

J-GLOBAL ID: 202001017615210907
researchmap Member ID: R000005166

Research Interests

Research Areas

Research History

Apr, 2020

Assistant Professor (Assistant Professor), College of Life Sciences, Ritsumeikan University

Education

- Mar, 2020

Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University
- Mar, 2017

Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University
- Mar, 2015

Department of Food Sciences and Nutritional Health, Faculty of Life and Environmental Sciences, Kyoto Prefectural University

Awards

Jul, 2022

Young Investigator Award 2022, International Congress on Nutrition and Integrative Medicine
Dec, 2019

Young Investigator Award, Pyroglutamyl peptides with anti-obesity, which are distributed in Japanese fermented foods, regulate ERK phosphorylation through GPR109A and GPR81, ICoFF2019

Saki Shirako
Nov, 2018

口頭発表銅賞, Administration of pyroGlu-Leu, distributed in fermented foods, increases antimicrobial peptides, Rattusin, and improves high fat diet induced-dysbiosis in rats, 2018 Global Food Science Student Competition (GFSSC) in Jiangnan University（中国）

Saki Shirako
Oct, 2017

Poster Award (First place), Oral administration of pyroGlu-Leu, widely distributed in protein hydrolysates and fermented foods, increases antimicrobial peptides in rat small intestine, ISNFF2017

Saki Shirako, Yasuki Matsumura, Kaori Ikeda, Nobuya Inagaki, Kenji Sato
Nov, 2015

Poster Award, Identification of glutathione-binding protein in human plasma after supplementation of glutathione, ICoFF2015

Saki Shirako, Sayori Wada, Wataru Aoi, Eun Young Park, Yasushi Nakamura, Kenji Sato

Papers

Identification of Anti-Inflammatory Compounds from Peucedanum praeruptorum Roots by Using Nitric Oxide-Producing Rat Hepatocytes Stimulated by Interleukin 1β

Ozaki H, Nishidono Y, Fujii A, Okuyama T, Nakamura K, Maesako T, Shirako S, Nakatake R, Tanaka K, Ikeya Y …

Molecules, 28(13) 5076, Jun 28, 2023 Peer-reviewed
Anti-inflammatory effects of hydrophobic constituents in the extract of the root cortex of Paeonia suffruticosa

Tatsuki Sato, Saki Shirako, Tetsuya Okuyama, Yukinobu Ikeya, and Mikio Nishizawa

Bioactive Compounds in Health and Disease, 5(8) 160-173, Aug 16, 2022 Peer-reviewed
Two new monoterpene esters from the pericarps of Alpinia zerumbet

Yuto Nishidono, Yuuna Iwama, Saki Shirako, Toshinari Ishii, Tetsuya Okuyama, Mikio Nishizawa & Ken Tanaka

Natural Product Research, Jul 18, 2022 Peer-reviewed
Anti-inflammatory effects of anthraquinones of Polygonum multiflorum roots

Siti Mariyah Ulfa, Saki Shirako, Mariko Sato, Dinia Rizqi Dwijayanti, Tetsuya Okuyama, Seiji Horie, Jun Watanabe, Yukinobu Ikeya, Mikio Nishizawa

Bioactive Compounds in Health and Disease, 5(6) 136-148, Jun 27, 2022 Peer-reviewedLead author
Detection of Decarboxylated Amino Acids after in Vitro Protease Digestion of the Hydrophilic Fraction of Crude Drug Extracts

Saki Shirako, Kenji Sato, Saki Moriwaki, Yukinobu Ikeya, Mikio Nishizawa

Biological and Pharmaceutical Bulletin, 45(2) 169-177, Feb 1, 2022 Peer-reviewed
Comparison of the anti-inflammatory activities of furanocoumarins from the roots of Angelica dahurica

Ryo Okada, Hazuki Abe, Tetsuya Okuyama, Yuto Nishidono, Toshinari Ishii, Tatsuki Sato, Saki Shirako, Ken Tanaka, Yukinobu Ikeya, Mikio Nishizawa

Bioactive Compounds in Health and Disease, 4(12) 287-300, Dec 20, 2021 Peer-reviewed
Identification of short-chain pyroglutamyl peptides in Japanese salted fermented soy paste (miso) and their anti-obesity effect

Saki Shirako, Yumi Kojima, Takeo Hasegawa, Toshikazu Yoshikawa, Yasuki Matsumura, Kaori Ikeda, Nobuya Inagaki and Kenji Sato

Journal of Food Bioactives, 12 129-139, Dec 31, 2020 Peer-reviewed
Pyroglutamyl leucine, a peptide in fermented foods, attenuates dysbiosis by increasing host antimicrobial peptide

Saki Shirako, Yumi Kojima, Naohiro Tomari, Yasushi Nakamura, Yasuki Matsumura, Kaori Ikeda, Nobuya Inagaki & Kenji Sato

npj Science of Food, 3 18-18, Oct 7, 2019 Peer-reviewed

Misc.

Recent Advances on Biological Functions of Peptides and Amino Acid Derivatives in Fermented Products Using Aspergillus Starter

Yifeng ZHEN, Saki SHIRAKO, and Kenji SATO

117(1) 6-17, Jan 15, 2022
[最近の研究] ジ・トリペプチドによって活性化／阻害されるオリゴペプチド（4残基以上）トランスポーターの存在とその意義

白子紗希, 佐藤健司

食品加工技術, 39(2) 9-17, 2019

Books and Other Publications

Pyroglutamyl peptides in Japanese fermented foods and protein hydrolysate enhance production of host-antimicrobial peptides and ameliorate microbial imbalance

Kenji Sato, Saki Shirako, Sayori Wada (Role: Contributor) (Original Author(s): Edited by Debasis Bagchi and Sunny E. Ohia)

Elsevier Science, Academic Press, Dec 10, 2021 (ISBN: 9780128212325)

Presentations

初代培養肝細胞における一酸化窒素誘導抑制作用を持つゼンコの成分の探索

尾﨑大夢, 中村海渡, 白子紗希, 池谷幸信, 西澤幹雄

第45回日本分子生物学会年会（日本分子生物学会）, Dec 2, 2022, 日本分子生物学会
ゴーヤー果実成分によるインスリン感受性改善効果および肝糖新生抑制効果

古谷太志, 白子紗希, ⻄澤幹雄, 向英里

第45回日本分子生物学会年会（日本分子生物学会）, Dec 2, 2022, 日本分子生物学会
Comprehensive analysis of Hydrophilic Fraction of Crude Drug Extracts based on digestion and absorption processes

Saki Shirako

2022 General Assembly of the European Society of Medicine (ESMED General Assembly), Aug 4, 2022, European Society of Medicine
Constituents that suppress nitric oxide production in green perilla and red perilla

Yukinobu Ikeya, Kyoko Tanaka, Kana Tatara, Saki Shirako, Tadayoshi Okumura, Mikio, Nishizawa

The 30th Annual Meeting of International Congress on Nutrition and Integrative Medicines, Jul 10, 2022, International Congress on Nutrition and Integrative Medicines
LC-MS/MS analyses of in vitro protease digests of ECLM, EAS, and OPLEF

Saki Shirako, Kenji Sato, Mikio Nishizawa

The 30th Annual Meeting of International Congress on Nutrition and Integrative Medicines, Jul 9, 2022, International Congress on Nutrition and Integrative Medicines
Determination of hydrophobic constituents of the root of Polygonum multiflorum using LC-MS/MS and their anti-inflammatory effect in rat hepatocytes

Saki Shirako, Siti Mariyah Ulfa, Takanari Hattori, Seiji Horie, Jun Watanabe, Faith Hays, and Mikio Nishizawa

70th ASMS Conference on Mass Spectrometry and Allied Topics, Jun 8, 2022, AMERICAN SOCIETY OF MASS SPECTROMETRY
初代培養肝細胞における一酸化窒素誘導抑制効果を持つトウキの主要成分の探索

神前萌, 引地ちひろ, 鳥屋尾奈々, 白子紗希, 池谷幸信, 西澤幹雄

第68回日本生化学会近畿支部例会, May 28, 2022
肝細胞における一酸化窒素産生誘導に対するチョウトウコウ成分の効果

弥永泰知, 岩佐晃輔, 白子紗希, 池谷幸信, 西澤幹雄

第68回日本生化学会近畿支部例会, May 28, 2022
肝細胞における一酸化窒素産生を抑制するタクシャ成分の探索

加藤咲月, 田渕麻衣, 奥陽香, 白子紗希, 池谷幸信, 西澤幹雄

第68回日本生化学会近畿支部例会, May 28, 2022
ラット肝細胞における一酸化窒素産生を抑制するサイシンの成分検討

山下友里花, 田邊大成, 白子紗希, 池谷幸信, 西澤幹雄

第68回日本生化学会近畿支部例会, May 28, 2022
Analysis of in vitro protease digests of functional foods by using LC-MS/MS

Saki Shirako

Virtual Symposium on Asian Foods and Traditional Drugs― Young Asian Researchers Association, Mar 3, 2022, Asia-Japan Research Institute, Ritsumeikan University
Anti-inflammatory Effects of Furanocoumarins From the Roots of Angelica dahurica

Tatsuki Sato, Ryo Okada, Saki Shirako, Mikio Nishizawa

SYMPOSIUM ON ORGANIC AND APPLIED CHEMISTRY 2021, Dec 22, 2021, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Brawijaya University
ゴーヤー果実に含まれる成分の肝糖新生抑制効果およびインスリン感受性改善効果

古谷太志, 白子紗希, 西澤幹雄, 向英里

第44回日本分子生物学会年会, Dec, 2021, 特定非営利活動法人日本分子生物学会
Analysis of in vitro protease digests of the hydrophilic fraction of crude drug extracts by using LC MS/MS

Saki Shirako

Joint Conference of Brawijaya University & Ritsumeikan University on Traditional Asian Drugs and Foods, Sep 16, 2021, Saki Shirako, supported by Asia-Japan Research Institute Advanced Research Program
Analysis of in vitro protease digest s of the hydrophilic fraction of crude drug extracts by using LC MS/MS

Saki Shirako

Joint Conference of Brawijaya University & Ritsumeikan University on Traditional Asian Drugs and Foods, Sep 16, 2021, Saki Shirako, supported by Asia-Japan Research Institute Advanced Research Program
初代培養肝細胞における一酸化窒素誘導抑制作用を持つゼンコの成分の探索

尾﨑大夢, 前迫貴徳, 中村海渡, 白子紗希, 池谷幸信, 西澤幹雄

第67回日本生化学会近畿支部例会, May 29, 2021
初代培養肝細胞における一酸化窒素誘導を抑制するチモの成分の探索

梶村美月, 坪田朋也, 白子紗希, 池谷幸信, 西澤幹雄

第67回日本生化学会近畿支部例会, May 29, 2021
オンジの初代培養肝細胞における一酸化窒素誘導を抑制する成分の探索

忠海奏, 増田佳奈, 白子紗希, 池谷幸信, 西澤幹雄

第67回日本生化学会近畿支部例会, May 29, 2021
In vitro人工消化による、生体内に吸収されうる生薬由来成分の探索

白子紗希, 佐藤健司, 池谷幸信, 西澤幹雄

第67回日本生化学会近畿支部例会, May 29, 2021
ラット肝細胞における一酸化窒素誘導を抑制するボタンピの成分の探索

佐藤辰紀, 白井葵, 奥山哲矢, 白子紗希, 池谷幸信, 西澤幹雄

第43回日本分子生物学会年会, Dec 4, 2020

Professional Memberships

Research Projects

Effect of decarboxylated amino acids found in Ziziphus jujuba for the improvement of frailty.

Early-Career Scientists, Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2025
回腸を標的とするピログルタミルペプチドによる腸内細菌叢改善作用メカニズムの解明

三島海雲記念財団 2022年度学術研究奨励金【自然科学部門】, Jul, 2022

白子紗希
“新規ロイシン誘導体”が秘める生理機能の解明に向けた基礎研究

2021 年度若手・女性研究者奨励金, 日本私立学校振興・共済事業団, Apr, 2021 - Mar, 2022
炎症性腸疾患の予防および治療を目指した生薬由来ペプチドの網羅的探索

2020年度研究推進プログラム（科研費獲得推進型）, Apr, 2020 - Mar, 2021