2015年11月6日
Pituitary metastasis of hepatocellular carcinoma presenting with panhypopituitarism: a case report.
BMC cancer
- 巻
- 15
- 号
- 開始ページ
- 863
- 終了ページ
- 863
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1186/s12885-015-1831-7
- 出版者・発行元
- BIOMED CENTRAL LTD
BACKGROUND: Metastasis to the pituitary gland is extremely rare and is often detected incidentally by symptoms associated with endocrine dysfunction. Breast and lung cancer are the most common primary metastasizing to pituitary gland. Metastasis from hepatocellular carcinoma to the pituitary gland is extremely rare, with only 10 cases having been previously reported. We present here the first case of pituitary metastasis of hepatocellular carcinoma presenting with panhypopituitarism diagnosed by magnetic resonance imaging. CASE PRESENTATION: We report the case of an 80-year-old Japanese woman who presented with the sudden onset of hypotension and bradycardia after having previously been diagnosed with hepatocellular carcinoma. Based on low levels of pituitary hormones, she was diagnosed with panhypopituitarism caused by metastasis of the hepatocellular carcinoma to the pituitary gland. Magnetic resonance imaging with arterial spin-labeling was effective in the differential diagnosis of the intrasellar tumor. The patient died despite hormone replacement therapy because of hypovolemic shock. CONCLUSION: Metastasis to the pituitary gland causes various non-specific symptoms, so it is difficult to diagnose. The present case emphasizes the importance of diagnostic imaging in identifying these metastases. Clinicians should consider the possibility of pituitary metastasis in patients with malignant tumors who demonstrate hypopituitarism.
- リンク情報
-
- DOI
- https://doi.org/10.1186/s12885-015-1831-7
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/26545979
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636744
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000365267500008&DestApp=WOS_CPL
- ID情報
-
- DOI : 10.1186/s12885-015-1831-7
- ISSN : 1471-2407
- PubMed ID : 26545979
- PubMed Central 記事ID : PMC4636744
- Web of Science ID : WOS:000365267500008