2013年7月
Effects of the Fluoroquinolone Antibacterial Drug Ciprofloxacin on Ventricular Repolarization in the Halothane-Anesthetized Guinea Pig
JOURNAL OF PHARMACOLOGICAL SCIENCES
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- 巻
- 122
- 号
- 3
- 開始ページ
- 205
- 終了ページ
- 212
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1254/jphs.13020FP
- 出版者・発行元
- JAPANESE PHARMACOLOGICAL SOC
The fluoroquinolone antibiotic ciprofloxacin has been reported to block delayed rectifier K+ channels at much higher concentrations than those at which it exerts its bactericidal activity. In this study using the halothane-anesthetized guinea pig, we assessed whether ciprofloxacin has a proarrhythmic activity. Ciprofloxacin at a clinically relevant dose of 3 mg/kg, i.v. did not affect any electrocardiographic parameters. At 10 mg/kg, it prolonged the QT interval and the duration of the monophasic action potential of the ventricle under sinus rhythm and constant ventricular pacing (n = 6). The extents of its effects on the ventricular repolarization phase were comparable to those of another fluoroquinolone antibiotic moxifloxacin at a clinically relevant dose of 3 mg/kg (n = 6). Meanwhile, the PR interval and QRS width were also increased by cipro-floxacin at 10 mg/kg, suggesting that the drug inhibited cardiac K+ channels as well as Na+ and Ca2+ channels in vivo. These results suggest that ciprofloxacin exerted a multi-ion channel-blocking action in the heart within the supra-therapeutic dose range. Therefore, careful observation may be necessary for patients with heart disease receiving a higher dose of ciprofloxacin in order to prevent the emergence of resistance.
- リンク情報
- ID情報
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- DOI : 10.1254/jphs.13020FP
- ISSN : 1347-8613
- PubMed ID : 23803533
- Web of Science ID : WOS:000322693500005