2019年
Decrease in p3-Alcβ37 and p3-Alcβ40, products of Alcadein β generated by γ-secretase cleavages, in aged monkeys and patients with Alzheimer's disease.
Alzheimer's & dementia (New York, N. Y.)
ダウンロード
回数 : 189
- 巻
- 5
- 号
- 1
- 開始ページ
- 740
- 終了ページ
- 750
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.trci.2019.09.015
- 出版者・発行元
- Wiley
Introduction: Neuronal p3-Alcβ peptides are generated from the precursor protein Alcadein β (Alcβ) through cleavage by α- and γ-secretases of the amyloid β (Aβ) protein precursor (APP). To reveal whether p3-Alcβ is involved in Alzheimer's disease (AD) contributes for the development of novel therapy and/or drug targets. Methods: We developed new sandwich enzyme-linked immunosorbent assay (sELISA) systems to quantitate levels of p3-Alcβ in the cerebrospinal fluid (CSF). Results: In monkeys, CSF p3-Alcβ decreases with age, and the aging is also accompanied by decreased brain expression of Alcβ. In humans, CSF p3-Alcβ levels decrease to a greater extent in those with AD than in age-matched controls. Subjects carrying presenilin gene mutations show a significantly lower CSF p3-Alcβ level. A cell study with an inverse modulator of γ-secretase remarkably reduces the generation of p3-Alcβ37 while increasing the production of Aβ42. Discussion: Aging decreases the generation of p3-Alcβ, and further significant decrease of p3-Alcβ caused by aberrant γ-secretase activity may accelerate pathogenesis in AD.
- リンク情報
-
- DOI
- https://doi.org/10.1016/j.trci.2019.09.015
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/31754625
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854065
- URL
- https://onlinelibrary.wiley.com/doi/pdf/10.1016/j.trci.2019.09.015
- URL
- https://onlinelibrary.wiley.com/doi/full-xml/10.1016/j.trci.2019.09.015
- URL
- https://onlinelibrary.wiley.com/doi/am-pdf/10.1016%2Fj.trci.2019.09.015
- ID情報
-
- DOI : 10.1016/j.trci.2019.09.015
- ISSN : 2352-8737
- eISSN : 2352-8737
- PubMed ID : 31754625
- PubMed Central 記事ID : PMC6854065