論文

査読有り 筆頭著者
2012年8月

Antitubercular Activity of Disulfiram, an Antialcoholism Drug, against Multidrug- and Extensively Drug-Resistant Mycobacterium tuberculosis Isolates

Antimicrobial Agents and Chemotherapy
  • Yasuhiro Horita
  • Takemasa Takii
  • Tetsuya Yagi
  • Kenji Ogawa
  • Nagatoshi Fujiwara
  • Emi Inagaki
  • Laurent Kremer
  • Yasuo Sato
  • Ryuji Kuroishi
  • YooSa Lee
  • Toshiaki Makino
  • Hajime Mizukami
  • Tomohiro Hasegawa
  • Ryuji Yamamoto
  • Kikuo Onozaki
    • … 全て表示
折りたたむ
巻
56
号
8
開始ページ
4140
終了ページ
4145
記述言語
英語
掲載種別
研究論文（学術雑誌）
DOI
10.1128/AAC.06445-11
出版者・発行元
AMER SOC MICROBIOLOGY
The antimycobacterial activities of disulfiram (DSF) and diethyldithiocarbamate (DDC) against multidrug- and extensively drug-resistant tuberculosis (MDR/XDR-TB) clinical isolates were evaluated in vitro. Both DSF and DDC exhibited potent antitubercular activities against 42 clinical isolates of M. tuberculosis, including MDR/XDR-TB strains.' Moreover, DSF showed remarkable bactericidal activity ex vivo and in vivo. Therefore, DSF might be a drug repurposed for the treatment of MDR/XDR-TB.
リンク情報
DOI
https://doi.org/10.1128/AAC.06445-11
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/22615274
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000306826300013&DestApp=WOS_CPL
ID情報
  • DOI : 10.1128/AAC.06445-11
  • ISSN : 0066-4804
  • PubMed ID : 22615274
  • Web of Science ID : WOS:000306826300013
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