2013年6月
Mast cell maturation is driven via a group III phospholipase A(2)-prostaglandin D-2-DP1 receptor paracrine axis
NATURE IMMUNOLOGY
- 巻
- 14
- 号
- 6
- 開始ページ
- 554
- 終了ページ
- +
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/ni.2586
- 出版者・発行元
- NATURE PUBLISHING GROUP
Microenvironment-based alterations in phenotypes of mast cells influence the susceptibility to anaphylaxis, yet the mechanisms underlying proper maturation of mast cells toward an anaphylaxis-sensitive phenotype are incompletely understood. Here we report that PLA2G3, a mammalian homolog of anaphylactic bee venom phospholipase A(2), regulates this process. PLA2G3 secreted from mast cells is coupled with fibroblastic lipocalin-type PGD(2) synthase (L-PGDS) to provide PGD2, which facilitates mast-cell maturation via PGD2 receptor DP1. Mice lacking PLA2G3, L-PGDS or DP1, mast cell-deficient mice reconstituted with PLA2G3-null or DP1-null mast cells, or mast cells cultured with L-PGDS-ablated fibroblasts exhibited impaired maturation and anaphylaxis of mast cells. Thus, we describe a lipid-driven PLA2G3-L-PGDS-DP1 loop that drives mast cell maturation.
- リンク情報
- ID情報
-
- DOI : 10.1038/ni.2586
- ISSN : 1529-2908
- PubMed ID : 23624557
- Web of Science ID : WOS:000319107600008