Shigekazu Sugino

Profile Information

Affiliation: Associate Professor, University Hospital University Hospital Central Clinical Facilities Intensive Care Unit, Tohoku University
: (Concurrent)Associate Professor, University Hospital, Anesthesiology

Degree: Ph.D.(Sapporo Medical University)

Researcher number: 00423765
J-GLOBAL ID: 201601019036967591
researchmap Member ID: 7000014695

External link

My mission is to produce the better anesthesiology research and care at the intersection of biomedical science and clinical practice.

Research Interests

Research Areas

Life sciences / Anesthesiology /

Research History

Apr, 2023 - Present

Associate Professor, Dept. of Anesthesiology and Perioperative Medicine, Tohoku University
Nov, 2019 - Mar, 2023

Assistant Professor, Dept. of Anesthesiology and Perioperative Medicine, Tohoku University
Jul, 2015 - Oct, 2019

Research Associate, Dept. of Anesthesiology and Perioperative Medicine, Tohoku University
May, 2013 - Jun, 2015

Visiting Research Asociate, Dept. of Anesthesiology and Perioperative Medicine, Pennsylvania State University College of Medicine
Apr, 2010 - Apr, 2013

Research Associate, Dept. of Anesthesiology, Sapporo Medical University
Apr, 2008 - Mar, 2010

Chief Anesthesiologist, Dept. of Anesthesia, Otaru Municipal Hospital
Oct, 2004 - Mar, 2008

Postgraduate Student, Dept. of Anesthesiology, Sapporo Medical University
Apr, 2003 - Sep, 2004

Staff Anesthesiologist, Dept. of Anesthesia, Nikko Memorial Hospital
Apr, 2002 - Mar, 2003

Staff Anesthesiologist, Dept. of Anesthesiology, Sapporo Medical University
Apr, 2001 - Mar, 2002

Staff Anesthesiologist, Dept. of Anesthesia, Kitami Red Cross Hospital
Apr, 2000 - Mar, 2001

Staff Anesthesiologist, Dept. of Anesthesia, Kushiro City General Hospital
Mar, 1999 - Feb, 2000

Resident, Dept. of Anesthesia, Asahikawa City Hospital
Apr, 1998 - Mar, 1999

Resident, Dept. of Anesthesiology, Sapporo Medical University

Education

- Mar, 2008

Anesthesiology, Graduate School of Medicine, Sapporo Medical University
- Mar, 1998

School of Medicine, Sapporo Medical University

Awards

Best Presentation Award, Effect of Dexmedetomidine on A Rat Model of Postoperative Nausea and Vomiting, JSA Hokkaido-Tohoku Branch 9th Annual Meeting

SUGINO Shigekazu

Major Papers

Antiemetic effects of baclofen in a shrew model of postoperative nausea and vomiting: Whole-transcriptome analysis in the nucleus of the solitary tract.

Daisuke Konno, Shigekazu Sugino, Tomoko F Shibata, Kazuharu Misawa, Yuka Imamura-Kawasawa, Jun Suzuki, Kanta Kido, Masao Nagasaki, Masanori Yamauchi

CNS neuroscience & therapeutics, 28(6) 922-931, Mar 3, 2022 Peer-reviewed
Crucial involvement of catecholamine neurotransmission in postoperative nausea and vomiting: Whole-transcriptome profiling in the rat nucleus of the solitary tract

Shigekazu Sugino, Daisuke Konno, Junko Abe, Yuka Imamura-Kawasawa, Kanta Kido, Jun Suzuki, Yasuhiro Endo, Masanori Yamauchi

Genes, Brain and Behavior, 20(6) e12759, Jun, 2021 Peer-reviewedLead authorCorresponding author
Long non-coding RNA MIR4300HG polymorphisms are associated with postoperative nausea and vomiting: a genome-wide association study.

Shigekazu Sugino, Daisuke Konno, Yosuke Kawai, Masao Nagasaki, Yasuhiro Endo, Tomo Hayase, Misako Yamazaki-Higuchi, Yukihiro Kumeta, Shunsuke Tachibana, Katsuhiko Saito …

Human genomics, 14(1) 31-31, Sep 14, 2020 Peer-reviewedLead authorCorresponding author
Effect of forced-air warming by an underbody blanket on end-of-surgery hypothermia: a propensity score-matched analysis of 5063 patients.

Hiroshi Sumida, Shigekazu Sugino, Norifumi Kuratani, Daisuke Konno, Jun-Ichi Hasegawa, Masanori Yamauchi

BMC anesthesiology, 19(1) 50-50, Apr 9, 2019 Peer-reviewed
Intraoperative auditory evoked potential recordings are more reliable at signal detection from different sensor sites on the forehead compared to bispectral index.

Yoshiya Ishioka, Shigekazu Sugino, Tomo Hayase, Piotr K Janicki

Journal of clinical monitoring and computing, 31(1) 117-122, Feb, 2017 Peer-reviewed
Massive Fulminant Thrombosis During Liver Transplantation in a Patient With a Previously Unknown Antithrombin Pathway Mutation.

Dmitri Bezinover, Shigekazu Sugino, Yuka Imamura-Kawasawa, Matthew S Bell, Zakiyah Kadry, Piotr K Janicki

A & A case reports, 7(11) 239-242, Dec 1, 2016 Peer-reviewed
Gα14 subunit-mediated inhibition of voltage-gated Ca2+ and K+ channels via neurokinin-1 receptors in rat celiac-superior mesenteric ganglion neurons.

Shigekazu Sugino, Mohamed Farrag, Victor Ruiz-Velasco

Journal of neurophysiology, 115(3) 1577-86, Mar, 2016 Peer-reviewedLead author
Efficacy and Safety of a Lidocaine and Ropivacaine Mixture for Scalp Nerve Block and Local Infiltration Anesthesia in Patients Undergoing Awake Craniotomy.

Tomohiro Chaki, Shigekazu Sugino, Piotr K Janicki, Yoshiya Ishioka, Yosuke Hatakeyama, Tomo Hayase, Miki Kaneuchi-Yamashita, Naonori Kohri, Michiaki Yamakage

Journal of neurosurgical anesthesiology, 28(1) 1-5, Jan, 2016 Peer-reviewed
Peripartum Anesthetic Management and Genomic Analysis of Rare Variants in a Patient with Familial Pulmonary Fibrosis.

Shigekazu Sugino, Brandon J Bortz, Sonia Vaida, Kunal Karamchandani, Piotr K Janicki

A & A case reports, 5(10) 169-72, Nov 15, 2015 Peer-reviewedLead author
TACR1 gene polymorphism and sex differences in postoperative nausea and vomiting

T. Hayase, S. Sugino, H. Moriya, M. Yamakage

ANAESTHESIA, 70(10) 1148-1159, Oct, 2015 Peer-reviewed
Pharmacogenetics of chemotherapy-induced nausea and vomiting.

Shigekazu Sugino, Piotr K Janicki

Pharmacogenomics, 16(2) 149-60, Jan, 2015 Peer-reviewedLead author
Association of μ-opioid receptor gene (OPRM1) haplotypes with postoperative nausea and vomiting.

Shigekazu Sugino, Tomo Hayase, Misako Higuchi, Katsuhiko Saito, Hiroyuki Moriya, Yukihiro Kumeta, Nahoko Kurosawa, Akiyoshi Namiki, Piotr K Janicki

Experimental brain research, 232(8) 2627-35, Aug, 2014 Peer-reviewedLead authorCorresponding author
Genetic factors associated with pharmacotherapy and background sensitivity to postoperative and chemotherapy-induced nausea and vomiting.

Piotr K Janicki, Shigekazu Sugino

Experimental brain research, 232(8) 2613-25, Aug, 2014 Peer-reviewed
Improved non-invasive total haemoglobin measurements after in-vivo adjustment

R. Miyashita, N. Hirata, S. Sugino, M. Mimura, M. Yamakage

ANAESTHESIA, 69(7) 752-756, Jul, 2014 Peer-reviewed
Genetic differences in response properties of rostral ventromedial medulla neurons to the μ-opioid receptor agonist DAMGO in mouse inbred strains.

Shigekazu Sugino, Akiyoshi Namiki, Michiaki Yamakage

Neuroscience letters, 517(2) 107-12, May 31, 2012 Peer-reviewedLead authorCorresponding author
Forehead is as sensitive as finger pulse oximetry during general anesthesia.

Shigekazu Sugino, Noriaki Kanaya, Masahito Mizuuchi, Masayasu Nakayama, Akiyoshi Namiki

Canadian journal of anaesthesia = Journal canadien d'anesthesie, 51(5) 432-6, May, 2004 Peer-reviewedLead authorCorresponding author

Misc.

107

眼咽頭筋型筋ジストロフィー患者におけるロボット支援腹腔鏡下手術の麻酔経験

泉山仁志, 鈴木潤, 船橋優太郎, 金谷明浩, 杉野繁一, 山内正憲

日本臨床麻酔学会第43回大会, Nov, 2023 Peer-reviewed
手術室看護師による術後疼痛管理チームの立ち上げ

滝沢香菜, 杉野繁一, 本間舞子, 鈴木潤, 高野淳, 竹森加菜子, 山内正憲

日本臨床麻酔学会第43回大会, Nov, 2023 Peer-reviewed
呼吸器外科から始める術後疼痛管理チームのすすめ

本間舞子, 杉野繁一, 鈴木潤, 高野淳, 山内正憲

日本臨床麻酔学会第43回大会, Nov, 2023 Peer-reviewed
術後疼痛管理チームにおける薬剤師の貢献

鈴木寿樹, 田中里奈, 森下啓, 本間舞子, 杉野繁一, 滝沢香菜, 高野淳, 矢吹志津葉, 鈴木潤, 松浦正樹 …

第33回日本医療薬学会年会, Nov, 2023 Peer-reviewed
術後疼痛管理チーム活動における診療看護師(NP)のタスクシェアリング

高野淳, 杉野繁一, 本間舞子, 鈴木潤, 矢吹志津葉, 山内正憲

第9回日本NP学会, Oct, 2023 Peer-reviewed
講座高齢患者の術後を見据えて麻酔法を選択する

間島卓哉, 杉野繁一

臨床麻酔, 47(9) 1041-1049, Sep, 2023 Peer-reviewedInvitedLast author
APS介入で減少したフェンタニルivPCAによる悪心嘔吐

本間舞子, 鈴木潤, 矢吹志津葉, 大西詠子, 齋藤秀悠, 山内正憲

日本ペインクリニック学会第57回学術集会, Jul, 2023 Peer-reviewed
COVID-19凝固障害患者におけるextracelluler vesicles産生量の比較;前向き観察研究

岩崎夢大, 武井祐介, 杉野繁一, 山内正憲

日本麻酔科学会第70回学術集会, Jun, 2023 Peer-reviewed
細胞外小胞に着目した人工呼吸関連肺傷害の内皮傷害マーカーの探索

武井祐介, 岩崎夢大, 紺野大輔, 入間田大介, 関根智宏, 齋藤秀悠, 杉野繁一, 鈴木潤, 山内正憲

日本集中治療医学会雑誌, 30(Suppl.1) S579-S579, Jun, 2023 Peer-reviewed
臨床に即した遷延性術後痛モデル動物の開発とtranscriptome profiling

鈴木潤, 杉野繁一, 齋藤秀悠, 本間舞子, 山内正憲

日本ペインクリニック学会誌, 30(5) 120-121, May, 2023 Peer-reviewed
嘔吐する実験動物スンクスを用いてPONVの機序をゲノムレベルで探索する

杉野繁一

Anet, 27(2) 10-13, Apr, 2023 Peer-reviewedInvitedLead authorCorresponding author
集中治療室における術後せん妄発症の危険因子

周穎哲, 鎌田ことえ, 杉野繁一, 萩平哲, 山内正憲

日本老年麻酔学会プログラム・抄録集, 35回 35-35, Mar, 2023 Peer-reviewed
剪断波速度を用いた筋緊張の定量化麻酔導入時における前向き観察研究

高桑こころ, 杉野繁一, 齋藤秀悠, 金谷明浩, 茂木章一郎, 山内正憲

日本臨床麻酔学会誌, 42(6) S181-S181, Oct, 2022 Peer-reviewed
【痛みの精密医療の展開に向けて】全身麻酔後の悪心嘔吐と精密医療

杉野繁一

Precision Medicine, 5(2) 123-126, Feb, 2022 Peer-reviewedInvitedLead authorCorresponding author
重複大動脈弓を合併した高齢者の胸腔鏡下食道癌手術の1症例

重田惟, 杉野繁一, 鎌田ことえ, 山内正憲

日本老年麻酔学会プログラム・抄録集, 34回 23-23, Feb, 2022 Peer-reviewed
【麻酔】術後悪心・嘔吐(PONV) 最新の指針にもとづく発症予測・予防・治療

関根智宏, 杉野繁一

Intensivist, 13(4) 755-763, Oct, 2021 Peer-reviewedInvitedLast author
EQUATORネットワークの各種指針を使って素敵な研究プロトコールを作ろう

杉野繁一

日本小児麻酔学会大会プログラム, 26回 75-75, Oct, 2021 Peer-reviewedInvitedLead authorCorresponding author
絞扼性イレウスの重症度と術前プロカルシトニン値の関係

角田博, 武井祐介, 杉野繁一, 山内正憲

Shock: 日本Shock学会雑誌, 35(1) 53-53, May, 2021 Peer-reviewed
凍結肩の診療の現況と治療指針の提言

山内正憲, 臼井要介, 杉野繁一, 山本宣幸

日本ペインクリニック学会誌, 28(5) 72-72, May, 2021 Peer-reviewedInvited
非侵害性刺激後の脳内c-fos発現に対するオキシトシン神経系の関与

齋藤秀悠, 日出間志寿, 西森克彦, 齊藤和智, 熊谷道雄, 村上徹, 杉野繁一, 山内正憲

日本ペインクリニック学会誌, 28(5) 76-77, May, 2021 Peer-reviewed

Major Presentations

Genetic and genomic mechanisms of perioperative complications in anesthesia care

Sugino Shigekazu

The 69th Annual Meeting of Japanese Society of Anesthesiologists, 2022 Invited
Fantastic protocols by fantastic guidelines of EQUATOR network

Sugino Shigekazu

The 40th Annual Meeting of Japanese Society for Clinical Anesthesia, 2021 Invited
Chronic Postsurgical pain in Elderly Patients

Shigekazu Sugino, Jun Suzuki

The 40th Annual Meeting of Japanese Society for Clinical Anesthesia, Nov 6, 2020 Invited

Teaching Experience

Apr, 2023 - Present

Bed-side Leaning on Anesthesiology: Acute Pain Service (Tohoku University)
Feb, 2021 - Present

Elective Bed-side Learning on Anesthesiology: History of Anesthesia Practice (Tohoku University)
Feb, 2021 - Present

Elective Bed-side Learning on Anesthesiology: Pre-OP (Tohoku University)
Apr, 2017 - Present

Attractive Research on Anesthesiology (Tohoku University)
Feb, 2020 - Mar, 2022

Bed-side Leaning on Anesthesiology: Blood Gas Analysis (Tohoku University)

Professional Memberships

Major Research Projects

Suncus Research for Elucidating the Genetic Mechanism in Postoperative Nausea and Vomiting

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2026

Shigekazu Sugino, Ichiro Miyoshi, Hideki Noguchi, Daisuke Konno
Quantification of Nociceptive Pain by EEG Gamma Oscillations in the Primary Somatosensory Cortex for Precision Postoperative Analgesia

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2025

Kotoe Kamata, Shigekazu Sugino, Toru Murakami, Kanta Kido, Satoshi Hagihira, Masanori Yamauchi
Novel Rat Model and Intervention for Elucidating the Molecular Mechanism in Chronic Postsurgical Pain

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2025

Masanori Yamauchi, Shigekazu Sugino, Kanta Kido, Tetsuya Kodama, Yoshinori Okada
Development of Adverse Events-free Local Anesthetics in Cryo-EM Structural Determination of Sodium Channels

Grants-in-Aid for Scientific Research Challenging Research (Exploratory), Grants-in-Aid for Scientific Research Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jul, 2021 - Mar, 2024

Masanori Yamauchi, Shigekazu Sugino, Takafumi Suzuki, Kengo Kinoshita
Single-cell Whole-transcriptome Analysis in Rat Basal Forebrain for Elucidating the Molecular Mechanism in Postoperative Delirium

Grants-in-Aid for Early-Career Scientists, Grant-in-Aid for Early-Career Scientists, Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2024

Daisuke Konno, Shigekazu Sugino
Backcross of inbred Suncus for Elucidating the Genetic Mechanism in Postoperative Nausea and Vomiting

Grants-in-Aid for Scientific Research Challenging Research (Exploratory), Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2019 - Mar, 2022
High-fat diet increases postoperative pain in rats

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Kido Kanta
Treatment strategy for severe COVID-19 induced coagulopathy based on the specific mechanisms

Basic Research on Infectious Diseases including COVID-19, Japan Agency for Medical Research and Development, Aug, 2020 - Mar, 2021

Koji Saito, Masanori Yamauchi, Yusuke Takei, Yudai Iwasaki, Shigekazu Sugino
Development of Multimodal Practice Guideline for Frozen Shoulder Focusing on Personalized Rehabilitation after Selective Nerve Block and Evaluation of Therapeutic Effects

Research Project on Elucidation of Chronic Pain, Japan Agency for Medical Research and Development, Apr, 2018 - Mar, 2021

Masanori Yamauchi Yosuke Usui Shigekazu Sugino Nobuyuki Yamamoto Shin-ichi Konno
Genome-wide linc RNA analysis in patients with neuropathic pain

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2021

Yamauchi Masanori
Development of antiemetic drugs for PONV by genome-wide long non-coding RNAs analysis

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

Endo Yasuhiro
Novel strategy for intensive care by using application of artificial intelligence to data mining of Diagnosis Procedure Combination payment system

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2019

Shiga Takuya, IKUMI saori, KOBAYASHI naoya, SUGINO shigekazu, SAITO koji, NAKAYAMA masaharu, FUJIMORI kenji, YAMAUCHI masanori
補完的全ゲノム関連解析による小児の覚醒時興奮の分子基盤の解明

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2016 - Mar, 2019

蔵谷紀文, 杉野繁一
Galpha14-mediated NK1 receptor cell signaling in the celiac-superior mesenteric ganglion

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

Yamauchi Masanori, RUIZ-VELASCO Victor, IMAMURA Yuka, ENDO Yasuhiro, MURAKAMI Toru
Whole transcriptome analysis of the brain in a shrew model of postoperative nausea and vomiting

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

Sugino Shigekazu, KONNO Daisuke, SUZUKI Jun, MISAWA Kazuharu, SHIBATA Tomoko, KAWAI Yosuke, IMAMURA Yuka, NAGASAKI Masao, KIDO Kanta
Association of epigenetic modulation in the TACR1 gene with opioid-induced nausea and vomiting

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2011 - 2013

SUGINO Shigekazu, YAMAKAGE Michiaki, HAYASE Tomo, TACHIBANA Shun-suke, NAWA Yuko, MORIYA Hiroyuki
Establishment of Personalized Analgesia for Postoperative Pain

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2008 - 2010

SUGINO Shigekazu, NAMIKI Akiyoshi, HAYASE Tomo, HIGUCHI Misako, KUMETA Yukihiro, SAITOU Katsuhiko, MORIYA Hiroyuki, KUROSAWA Nahoko
延髄痛覚受容ニューロン(RVMニューロン)の機能特性への遺伝的影響

科学研究費助成事業若手研究(B), 若手研究(B), 日本学術振興会, 2006 - 2007

杉野繁一

Profile Information

Research Interests

Research Areas

Research History

Education

Awards

Major Papers

Misc.

Major Presentations

Teaching Experience

Professional Memberships

Major Research Projects

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Coauthors