2017年8月
Caspase-dependent non-apoptotic processes in development
CELL DEATH AND DIFFERENTIATION
- ,
- 巻
- 24
- 号
- 8
- 開始ページ
- 1422
- 終了ページ
- 1430
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/cdd.2017.36
- 出版者・発行元
- NATURE PUBLISHING GROUP
Caspases are at the core of executing apoptosis by orchestrating cellular destruction with proteolytic cascades. Caspase-mediated proteolysis also controls diverse nonlethal cellular activities such as proliferation, differentiation, cell fate decision, and cytoskeletal reorganization. During the last decade or so, genetic studies of Drosophila have contributed to our understanding of the in vivo mechanism of the non-apoptotic cellular responses in developmental contexts. Furthermore, recent studies using C. elegans suggest that apoptotic signaling may play unexpected roles, which influence ageing and normal development at the organism level. In this review, we describe how the caspase activity is elaborately controlled during vital cellular processes at the level of subcellular localization, the duration and timing to avoid full apoptotic consequences, and also discuss the novel roles of non-apoptotic caspase signaling in adult homeostasis and physiology.
- リンク情報
- ID情報
-
- DOI : 10.1038/cdd.2017.36
- ISSN : 1350-9047
- eISSN : 1476-5403
- Web of Science ID : WOS:000405106000013